Search PubMed⌕ Search

Biomedical subjects

S Ueda

Publications and source records attributed to S Ueda.

At least 1,063 records · Page 59Linked to original sources
PubMed1981

Actions of some autonomic drugs on isolated dog quiescent ureter.

Actions of some autonomic drugs on upper, middle and lower portion of isolated dog ureters under quiescent state were investigated quantitatively. Noradrenaline and adrenaline at lower concentrations evoked contractions in each portion of the ureters and increased the concentration-dependent frequency and tension of these contractions, but attenuated them at higher concentrations. Phentolamine significantly depressed these contractions, while propranolol enhanced them. Phenylephrine increased the concentration-dependent frequency and tension of contractions, which were suppressed by phentolamine. Acetylcholine at higher concentrations produced contractions of the ureters, and phentolamine or hexamethonium suppressed them. The results indicate that ureteral contractions may be stimulated through an activation of alpha-adrenoceptors and be attenuated through an activation of beta-adrenoceptors, and that acetylcholine may release noradrenaline from sympathetic nerve endings through an activation of presynaptic nicotinic receptors, resulting in ureteral contractions.

Animals↗
PubMed1981

Further investigations on potassium-induced automaticity of isolated human renal artery.

Experiments were designed to investigate generation of automaticity of isolated human renal arteries induced by administration of potassium in vitro. Helical strips of human renal arteries showed marked oscillations in the potassium-induced contractions which persisted for 2 hr. Indomethacin and aspirin dose-dependently inhibited these oscillations. Tranylcypromine and mepacrine also had an inhibitory action on the oscillations of the strips induced by potassium. In the strips which reached a steady state 2 hr after administration of potassium, phospholipase A2 and bradykinin produced marked oscillations. Our results indicate that human renal arteries can generate automaticity in the contractions induced by potassium, and that such automaticity may be related to the biosynthesis of prostaglandins.

Adult↗
PubMed1981

Oscillation of intracellular Cl- activity and membrane potential in cultured fibroblasts (L cells).

The intracellular Cl-activity (aCli) and the membrane potential (Vm) were simultaneously measured in cultured L-strain fibroblasts, using a Cl- selective liquid ion-exchanger microelectrode and a standard microelectrode. The oscillations of aCli and Vm were found to occur concomitantly. A decrease in the aCli value was associated with the spontaneous hyperpolarization. The depolarization produced by current injection resulted in an increase in aCli. These data suggest that the membrane permeability to Cl- is significantly high during the Vm oscillation in the L cell.

Animals↗
PubMed1981

Hemoglobin Yusa (beta 21 (B3) Asp leads to Tyr), a new abnormal hemoglobin found in Japan.

An electrophoretically slowly moving hemoglobin variant, Hb Yusa, was found in a 48-year-old man, his younger sister and mother. No clinical or hematological abnormalities were seen in the individuals heterozygous for this mutant gene. Structural studies of this abnormal hemoglobin showed a new type substitution of beta 21 (B3) Asp leads to Tyr. The percentage of the abnormal hemoglobin in the hemolysate was 40.8. The hemoglobin had neither instability nor functional abnormality.

Amino Acids↗
PubMed1981

Concomitant appearance of antibodies to two viruses in cerebrospinal fluid of an infant with acute encephalitis.

Acute encephalitis developed in a 5 1/2-month-old infant with a previous history of uncomplicated measles at 4 months of age. The patient survived his acute illness with resultant severe neurological sequelae. The serum complement fixing antibody titer for herpes simplex virus in the early phase of the illness was less than 1:4, and increased significantly to 1:64 in the convalescent phase. Antibody was also demonstrated in the cerebrospinal fluid. Antimeasles antibody was found in the cerebrospinal fluid in the early convalescent stage and remained at a detectable level for at least 1 month. Moreover, at least 71% of the total protein in the cerebrospinal fluid was IgG. Although brain biopsy for viral isolation was not performed, the most probable diagnosis was herpes simplex virus encephalitis, and the concomitant appearance of measles antibody in the cerebrospinal fluid may have been due to leakage of measles antibody from the blood into the cerebrospinal fluid due to disturbance of the blood-brain barrier.

Acute Disease↗
PubMed1981

Population genetic studies of the Philippine Negritos. III. Identification of the carbonic anhydrase-1 variant with CA1 Guam.

Investigation of blood samples from 277 Mamanwas of northeastern Mindanao, Philippines, confirmed the concentration of the variant carbonic anhydrase-1 (CA1 3N) in this group. The frequency for the variant allele was estimated at .217 +/- .017. It occurs also in the Manobos, the Mongoloid indigenous inhabitants of the same district, although the frequency is low (.019 +/- .008). Survey of samples from other Philippine populations, including the Aeta and the Ifugao of Luzon, failed to find variants. This findings suggests different origins of the Aeta and the Mamanwa, although both are usually referred to as Negritos. The Ca1 3N protein was purified by affinity chromatography using azosulfonamide and rechromatography on a DEAE-Sephadex column. The tryptic peptide pattern of CA1 3N was similar to that of CA1 Guam already reported. Furthermore, amino acid analyses of the tryptic peptides indicated that CA1 3N is characterized by the substitution 253 Gly leads to Arg, confirming the identity of this variant with CA1 Guam. The widespread occurrence of CA1 3 variants in the Western Pacific suggests that this variant was once common in an aboriginal population of this region, from which it was scattered by gene flow.

Black People↗
PubMed1981

Mutagenicity of smoke condensates induced by CO2-laser irradiation and electrocauterization.

Smoke condensates generated from mucous membrane of the canine tongue irradiated with a CO2 laser showed mutagenicity on Salmonella typhimurium TA98 under metabolic activation with S9 mix. Strain TA100 was not so sensitive to the condensates with or without S9 mix. Smoke condensates from electrocauterization on the mucosa of the canine tongue also showed mutagenic activity on TA98 and TA100 with S9 mix. The revertant number per mg of the smoke condensates from laser irradiation was one-half that of the smoke condensates from electrocauterization (1623 and 3371) in TA98. The mutagenic potency observed was comparable to that of cigarette smoke. The amount of these smoke condensates from 1 g of tissue was equivalent to those from 3--6 cigarettes as to total mutagenicity.

Animals↗