Biomedical subjects
Publications and source records attributed to S Tsuchida.
The effect of verapamil on the in-vivo bladder and urethra was investigated in female dogs. The bladder and urethral pressure responses to electrical stimulation of the pelvic and hypogastric nerves were decreased by verapamil.
Paired extraluminal strain gauge force transducers were implanted in the urethra to measure separately and simultaneously both longitudinal and transverse movements of the urethra. The advantage of our paired strain gauge force transducers is that both longitudinal and transverse changes of urethral movements can be detected.
A rabbit model with a megaureter was produced by the partial obstruction of the ureter. The resultant dilatation obtained after the chronic obstruction (more than 100 days) was approximately 4 times greater than the normal ureteral diameter.
The urethral pressure profile (UPP) was recorded in anterior, posterior, and right and left lateral portions of the canine urethra using a newly designed catheter with only one eye around the circumference of the tip for UPP recording. Our single-eye catheter made it possible to measure UPP in the four aspects separately and confirmed that there was a directional difference in UPP.
Conduction velocity of excitation in various regions of the canine pelviureter was studied through the simultaneous recordings of electromyograms at four sites of the canine pelvicalyceal preparation. The pelviureteral system was maintained in the condition which was similar to in vivo situation by infusion of oxygenated Krebs-Ringer solution into the renal pelvis at the average flow rate of living dogs. The conduction velocity was slowest in the proximal region of the pelvis where the pacemaker was located, i.e., about 5.8 mm/sec on an average. The velocity gradually increased in the distal region of the pelvis and the ureter. It was suggested that the conduction velocity of excitation was significantly different in the proximal area of the pelvis, the distal area of the pelvis and the ureter.
The M-mode scanning images of urethra, detrusor pressure and urine flow rate during voiding were recorded together on the line scan recorder, and allowed for plotting and calculation of some valuable urodynamic parameters by computer evaluation. This procedure will permit first application of M-mode scanning and new direction on urodynamics.
A modified method of percutaneous introduction of a suprapubic double lumen catheter (8 Fr) into the bladder for urodynamic examination is described. This method permits to fill the bladder at the filling rate about 50-60 ml/min from the standard drip set, and the catheter can be percutaneously introduced into the bladder with safety.
Experiments in vitro were performed to compare effects of noradrenaline and acetylcholine on the pyeloureter, both of which activate ureteral peristalsis. Noradrenaline elevated the baseline renal pressure to accelerate the ureteral peristalic pace in a ratio of 1:1 with the pacemaker discharge at the pelvicalyceal border (PC-border). Acetylcholine also accelerated the ureteral pace for a short time, as compared with the effect of noradrenaline. The baseline renal pelvic pressure dropped after administration of acetylcholine. Noradrenaline a little quickened the rhythm of the pacemaker contraction at the PC-border, and acetylcholine also quickened the pacemaker rhythm. These data suggest that noradrenaline and acetylcholine, which both activate pelviureteral peristalsis, exert different effects on pelvic pressure.
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The urethral pressure profile (UPP) was studied and compared in anesthetized and decerebrated dogs. The maximum urethral closure pressure (UPmax) was measured in various procedures. In anesthetized dogs UPmax was 70.9 +/- 22.9 cmH2O (mean +/- S.D.) in control, 40.2 +/- 16.4 cmH2O in laparotomy and 26.5 +/- 12.5 cmH2O in resection of pubic bone. As procedures were added, UPmax decreased, and the shape of UPP in anesthetized dogs showed remarkable change. In decerebrated dogs UPmax was 96.9 +/- 14.9 cmH2O in control, 77.5 +/- 28.0 cmH2O in decerebration, 78.1 +/- 7.0 cmH2O in 3 hours after decerebration, 79.0 +/- 6.8 cmH2O in laparotomy and 49.6 +/- 7.0 cmH2O in resection of pubic bone. UPP in decerebrated dogs generally kept its shape in various procedures and UPmax showed no change before and after laparotomy. Therefore, decerebrated dogs were considered to be useful for the experimental model of UPP.
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Regional arterial infusion of high doses of anti-cancer drugs combined with direct hemoperfusion was done in 12 patients with malignancies of the urinary tract. The perfuser contained 130 gm. activated charcoal, which was coated with cellulose. General toxicity caused by escape of the drug from the tumor area was prevented by adsorption within activated charcoal. The capacity of activated charcoal to adsorb doxorubicin hydrochloride was excellent, as determined by measurements of plasma concentration. With this method, objective tumor reduction was noted in 84 per cent of the patients with prostatic or bladder carcinoma, although results were disappointing in patients with renal cell carcinoma.
A three-year-old boy was operated on with the diagnosis of anatomically corrected malposition of the great arteries (S,D,L), ventricular septal defect, and mitral regurgitation. During the operation, it was found that the subpulmonary conus was absent. Ventricular septal defect was patch-closed, and the mitral valve was repaired. The patient was well after the surgery. This is the first case report to our knowledge of the successful surgical repair in anatomically corrected malposition of the great arteries without subpulmonary conus. Anatomically corrected malposition of the great arteries does not always have bilateral conus as once proposed, and the importance of the differentiation from the corrected transposition of the great arteries is emphasized.
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