Search PubMed⌕ Search

Biomedical subjects

S Tsuchida

Publications and source records attributed to S Tsuchida.

At least 271 records · Page 15Linked to original sources
PubMed1985

The estimation of urine bolus volume for patients with congenital hydronephrosis.

A new examination (bolusmetry) to evaluate the urine transport function of the ureteropelvic system was performed in 7 adult patients with congenital unilateral hydronephrosis. Whistle-tipped Fr. 5 catheters were introduced to each ureter about 5 cm proximal from the ureteral orifice by transurethral endoscopic technique. Bolus volume and frequency, and changes in them caused by furosemide injection, were estimated by using a drop counter which was connected to the terminal end of the ureteral catheter. Bolusmetry was performed comparing the hydronephrotic side and the healthy side, pre and postoperatively, and these results were then compared with a conventional examination. We obtained the following results: Bolus volume of the hydronephrotic side was 0.05 +/- 0.02 (mean +/- S.D.) ml at oliguric state, and it was significantly lower than the value of the healthy side which was 0.19 +/- 0.07 ml. Injection of diuretics increased the bolus volume of the healthy side ten times or more. On the other hand, the bolus volume of the hydronephrotic side was increased only slightly by the injection of furosemide, it being approximately one-fourth of the value of the healthy side. The value of bolus frequency was similar to peristaltic frequency which was measured by the electromyogram. The tendency of a decrease was noticed in bolus frequency of the hydronephrotic side but it was not significant. Of patients with severe hydronephrosis, the bolus volume of the hydronephrotic side was decreased and the response to the diuretics was not so significant. By bolusmetry, functional or organic obstruction of the ureteropelvic junction was detected. Of 3 patients who had nephrectomy or nephrostomy, the kidney function had deteriorated severely. The bolus volume was lower than 0.25 ml at the diuretic state. Bolus volume was increased postoperatively in 3 of 4 patients who had received pelvioplasty. One patient did not show the formation of bolus by the injection of diuretics, and the cause of the hydronephrosis was functional obstruction of the pelvioureteric junction. We concluded that bolusmetry is a valuable method for evaluation of the function of urine transport in the ureteropelvic system. Especially in hydronephrosis, bolusmetry is a useful in the choice of operative procedure, and for postoperative evaluation.

Adult↗
PubMed1985

Evaluation of the pelvioureteral function through a new urine bolusmetry: simultaneous measurement of urine bolus volume and electroureterogram.

New equipment to evaluate the urine transport function of the ureteropelvic system has been developed. Simultaneous measurement of urine bolus volume and electrical activity in the ureter is possible by means of this equipment. A urine bolus volume measuring system, which is based on the heat electrical method, is located in the probe tip, and bipolar electrodes for EMG are located in the stem of the Fr. 4 ureteral catheter. Two kinds of experiments were performed. One was an examination of the new probe through a pervioureteric model using an infusion pump and Nelatons' catheters of various diameters. The other was an animal experiment. The changes in ureteral peristalsis and urine bolus volume in response to diuretics were examined in mongrel dogs through application of this equipment. The following results were obtained: There was a logarithmic relation between perfusion flow rate in catheters used as ureteral models and the values of voltage depression measured by the heat electrical method. The urine bolus volume was calculated closely through a formula which had been developed from the model experiments. In animal experiments, the bolus volume increased significantly and a transient increase in peristalsis was noted after the administration of diuretics although there was no significant change in peristaltic velocity. Some pelvioureteric function parameters, i.e. peristaltic frequency, peristaltic velocity, urine bolus volume, volume, bolus length and ureteral width, are feasible calculations. These results indicate that bolusmetry by using this new probe is a valuable method for evaluation of urine transport function in the pelvioureteric system, and suitable for clinical use as well as animal experiments.

Animals↗
PubMed1985

Relationship between pelviureteral peristaltic frequency and urine flow change evoked by autonomic drug administration.

Parallel recording of renal pelvic pressure, ureteral electromyogram and urine volume was carried out in dogs given intravenous injections of noradrenaline, isoproterenol or acetylcholine. With noradrenaline, an increase in urine volume was observed coincidentally with an elevation of renal pelvic pressure and an increase in frequency of ureteral peristalsis. In response to isoproterenol, the urine volume diminished in harmony with flattening of pelvic pressure waves and the disappearance of ureteral peristalsis. Conversely, ureteral peristalsis increased in frequency immediately after the administration of acetylcholine, while the urine volume diminished.

Acetylcholine↗
PubMed1985

Changes in the ureteral peristaltic rate and the bolus volume in gradual and rapid urinary flow increase.

The electromyogram and bolus volume of ureteral peristalsis were measured during gradual and rapid urinary flow increase, using 16 mongrel dogs. When the urine flow was increased rapidly by administration of diuretics, the ureteral peristaltic rate always increased first, then the urine bolus volume increased and finally the ureter became a urinary column without forming the urine bolus. When the urine flow was increased gradually by intravenous drip infusion of saline solution, the ureteral peristaltic rate and urine bolus volume did not always increase in spite of urinary flow increase. The peristaltic rate and bolus volume helped each other for effective urinary transport, as both of them not only always increase but also one of them occasionally decreased.

Animals↗
PubMed1985

Effects of dobutamine on cyclic AMP content in canine upper urinary tract tissue.

There was no regional difference in tissue cAMP content throughout the upper urinary tract specimens obtained from dogs immobilized by pancuronium bromide (0.1 mg/kg, i.v.). The cAMP content was increased in all regions examined 5 min after administration of dobutamine (1 mg/kg, i.v.) and pancuronium bromide. The increase was much higher in the pelvicalyceal region than in the other upper urinary tract tissue. The responsiveness of the pelvicalyceal region where pacemaker cells for ureteral peristalsis exist is considered to be higher than that in the other upper urinary tract tissue in respect to dobutamine-induced cAMP increase.

Animals↗
PubMed1985

Effects of dobutamine on the in vivo urethra in the female dog.

The effect of dobutamine on the proximal urethra was investigated in vivo in female dogs. Dobutamine administered intra-arterially at the bifurcation of the iliac artery produced a rise in pressure and shortening along the transverse axis in the urethra.

Animals↗
PubMed1985

Comparison of the various forms of glutathione S-transferase with glucose-6-phosphate dehydrogenase and gamma-glutamyltranspeptidase as markers of preneoplastic and neoplastic lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine.

Alterations in gamma-glutamyl transpeptidase (gamma-GT) and alkaline phosphatase (ALP) activities and binding of specific antibodies to glucose-6-phosphate dehydrogenase (G6PDH), gamma-GT and the A, B, C, D, and P forms of glutathione S-transferase (GST-A, -B, -C, -D, and -P, respectively) in preneoplastic and neoplastic lesions induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) in the rat kidney were investigated. Morphologically the lesions were of basophilic type and were classified either as altered tubules or adenomas, the latter being further subdivided into microadenomas and adenomas depending on size and the presence of compression. The fact that all lesions demonstrated only weak (or negative) gamma-GT, ALP and GST-B stainings, all of which are normally evident in proximal tubules, and also the occasional finding of cells bearing a periodic acid-Schiff-positive apical brush border within altered tubules strongly positive for GST-A, indicated their histogenesis from the proximal segment of the nephron. Thus a directed shift to a phenotype opposite to that observed in the cells of origin was demonstrated. Comparison of phenotype within the range of EHEN-induced lesions strongly suggested putative preneoplastic character for the altered tubules. Transition to adenomas appeared to be correlated with progressive loss of GST-A and moderate to slight increase of G6PDH.

Adenoma↗
PubMed1985

[Clinical evaluation of cefmenoxime (CMX) for complicated urinary tract infection].

Cefmenoxime (CMX), a new semisynthetic antibiotic, was administrated in 29 cases diagnosed as complicated urinary tract infection. All patients received drip injection of 2 g (twice a day) for 5 days. Clinical results were excellent in 1 patient (3.4%), good in 15 patients (51.8%) and poor in 13 patients (44.8%). Effectiveness rate was 55.2%. In bacteriological response, out of 35 strains 27 (77.1%) strains were eradicated and 8 (22.9%) strains persisted. As for side effects, except one case of transient diarrhea after administration, no noteworthy reactions were observed. Laboratory abnormalities attributed to CMX treatment consisted of 4 cases of elevated serum transaminase and 2 cases of elevated serum creatinine.

Adult↗
PubMed1985

Present role of stereotactic thalamotomy for parkinsonism. Retrospective analysis of operative results and thalamic lesions in computed tomograms.

14 cases of unilateral and 5 cases of bilateral thalamotomy for parkinsonism were reviewed, with 32-144 months' (mean 67.8) and 54-212 months' (mean 110) follow-up, respectively, after the initial operation. Rigidity and tremor disappeared in approximately 80% of cases and was reduced in the remaining 20%. 68% improved by one or two grades in the Hoehn-Yahr scale after operation. Thalamotomy abolished dyskinesias and on-off phenomena on the operated sides. 36% of cases discontinued levodopa therapy after operation. CT study of the lesions suggested that destruction of a large part of basal Vop was most important to obtain the best results.

Adult↗
PubMed1984

Renal artery aneurysms in solitary kidney of woman with potentiality of pregnancy.

Although renal artery aneurysms in solitary kidney are rare, we encountered a case of congenital solitary kidney with noncalcified renal artery aneurysm. The patient was twenty-four years' old and wanted to become pregnant. We treated her by surgical methods. The operative procedure, aneurysmectomy and ligatures of the influx and exflux vessels of the aneurysm, was performed by a transaneurysmal approach. Ultrasound tomography during surgery was convenient to detect the intrarenal aneurysm. The postoperative course was uneventful apart from a transient increase of serum creatinine and blood urea nitrogen. The advisability of surgical methods for aneurysms in solitary kidneys and the implications in pregnancy are discussed.

Adult↗