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Biomedical subjects

S Tani

Publications and source records attributed to S Tani.

At least 181 records · Page 10Linked to original sources

Nasal cancer mortality in areas with a high proportion of wood and furniture workers in Japan.

To see whether or not death from nasal cancer (ICD 160) increased in the areas where a proportion of woodworkers is high in Japan, two studies were carried out by examining standardized mortality ratios (SMRs) of nasal cancer at a Health Center and in 10 cities selected as wood industry areas. No excess risk of nasal cancer with statistical significance was seen. It would be very difficult to conclude that there is a definite excess risk of nasal cancer among woodworkers in Japan. Further investigation is needed.

Adolescent↗

Purification and properties of a cathepsin D-like acid proteinase from rat gastric mucosa.

A unique acid proteinase was purified from rat gastric mucosa by DEAE-Sepharose CL-6B chromatography, gel filtration and isoelectric focusing. The purified enzyme was homogeneous by polyacrylamide disc gel electrophoresis. The molecular weight of the enzyme was estimated to be 86000 by gel filtration on a Sephadex G-100 column. In SDS-polyacrylamide gel electrophoresis, the enzyme showed a single band corresponding to a molecular weight of 42000. So it was concluded that the native enzyme is composed of two identical monomeric units. The enzyme is a glycoprotein and its isoelectric point was determined to be 4.33. The enzyme hydrolyzed bovine hemoglobin with maximum activity at pH 3.0, but it showed considerably lower activity on bovine serum albumin or casein than on bovine hemoglobin. The enzyme was strongly inhibited by pepstatin, but not by urea or thiol-reactive inhibitors. These results lead us to conclude that this enzyme is a cathepsin D-like acid proteinase.

Amino Acids↗

[Diphyllobothrium latum infection in Akita Prefecture. Infections occurring from 1974 to 1981 and the clinical effect of paromomycin sulfate].

Forty-one patients, aged 2 to 68 years old, infected with Diphyllobothrium latum in Akita prefecture were treated using paromomycin sulfate from 1974 to 1981. Paromomycin sulfate was administered orally in a single dose of 20, 30 mg/kg or 50 mg/kg. Twenty-three cases expelled tapeworms. However, only 9 (28.1%) out of 32 tapeworms expelled had their scolex. It can be said that all cases were successfully treated with paromomycin sulfate, since they showed the egg-negative on 3 weeks or 1 month after the treatment. The drug was well tolerated and no side effects were encountered in any patients. It was suggested that paromomycin sulfate was effective and also safe therapeutic agent for the treatment of D. latum infection.

Adolescent↗

Effects of pentagastrin, histamine, carbamylcholine and catecholamines on gastric secretion, motility and emptying in the rat.

We developed a simplified method for the simultaneous measurement of gastric secretion and gastric motility in the rat. By using this method, we investigated the actions of pentagastrin, histamine, carbamylcholine and catecholamines on the stomach. Carbamylcholine stimulated acid secretion and induced contraction of the stomach, but norepinephrine tended to inhibit acid secretion and induced relaxation of the stomach. Histamine induced relaxation first and then contraction after 2-5 min. Pentagastrin induced a relaxation that did not show dose dependence, but tachyphylaxis. Isoproterenol, which stimulated acid secretion in our experiments, induced relaxation of the stomach in a dose-dependent manner. We also investigated the relationship between gastric motility and gastric emptying. Carbamylcholine caused an enhancement of gastric emptying, but isoproterenol caused its suppression. Pentagastrin, histamine and norepinephrine did not affect gastric emptying. As shown in the results of our experiments, carbamylcholine caused stimulation of acid secretion, contraction of the stomach, and enhancement of gastric emptying. However, other secretagogues did not always induce contraction of the stomach or increase gastric emptying.

Animals↗

Genetic variation of pepsinogen 1 in the rat.

A pepsinogen (Pg 1) polymorphism was observed in gastric mucosal samples of Wistar rats by polyacrylamide slab gel electrophoresis. Three phenotypes were observed: S (a slow-moving band), F (a fast-moving band), and FS (both bands). Pg 1 variation was controlled by a pair of codominant alleles at a single autosomal locus. Interstrain variation of Pg 1 was studied in five strains of laboratory rats. Genetic variation of Pg 1 was detected only in the Wistar strain.

Alleles↗

[Traumatic aneurysm of the posterior inferior cerebellar artery (author's transl)].

The incidence of traumatic intracranial aneurysms are rare. In review of literature, only six cases of traumatic aneurysms in posterior fossa are reported. The patient, 15-year-old girl, was admitted on Dec. 18th, 1979, presented with unconsciousness after a traffic accident. She was developed impaired consciousness and left hemiparesis with right hemotympanum and nasal bleeding. Skull film showed an occipital linear fracture and a laminal fracture of the atlas. CT scan demonstrated traumatic subarachnoid, intraventricular hemorrhage and pneumocephalus. After accident, she regained consciousness with conservative therapy, but she deteriorated on the 10th hospitalized day. On the 17th day, lumbar puncture and CT scan revealed recurrent subarachnoid and intraventricular hemorrhage. The saccular aneurysm on the lateral medullary segment of the right posterior inferior cerebellar artery was obtained by cerebral angiogram on the 35th day. The configuration and size of the aneurysm was easily demonstrated by CT scans and cerebral angigrams. On the 43rd day, the clipping of the common trunk of the right posterior inferior cerebellar artery was employed. Her postoperative course was uneventful and she was discharged on the 97th day in good condition. This aneurysm was suggested to be induced by severe head injury with clinical ad operative findings. With the introduction of CT scan, CT scan is more available diagnostic modality than cerebral angiography in the follow up study with severe head injuries. And in the absence of pathological CT scan findings, suspicion of traumatic cerebrovascular impairments such as aneurysm should be paid. As the conservative management of traumatic intracranial aneurysms carries high mortality rate up to 30-50%, the prompt diagnosis and direct surgical intervention are recommended.

Adolescent↗