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Biomedical subjects

S Tani

Publications and source records attributed to S Tani.

At least 199 records · Page 11Linked to original sources
PubMed1980

Gyriform calcification after purulent meningitis.

A 2-month-old baby developed bilateral frontoparietal gyriform calcification after purulent meningitis. Biopsy revealed severe cerebral cortical degeneration with many calcified foci. Another feature of interest was reabsorption of calcification over a period of 4.5 months.

Brain Diseases↗
PubMed1980

Biochemical and immunological characterizations of rat pepsinogens and pepsins.

Biochemical and immunological properties of two kinds of pepsinogens isolated from the gastric mucosal extracts of adult Wistar rats were studied. Their activated enzymes were prepared from the zymogens using a DEAE-Sepharose CL-6B column. The isoelectric points of pepsinogens I and II were estimated to be 3.90 and 3.75, respectively, by isoelectric focusing, and those of pepsins I and II to be 3.60 and 3.45, respectively. Amino acid compositions of the two pepsinogens or pepsins were strikingly similar to each other and neither pepsinogen I nor II contained organic phosphate. The biochemical properties of rat preparations compared with porcine pepsinogens A and C and pepsins A [EC 3.4.23.1] and C [EC 3.4.23.3] showed that rat pepsinogens and pepsins resembled porcine pepsinogen C and pepsin C, respectively. Pepsinogens I and II were demonstrated to share a similar immunogenic molecular structure by double diffusion analysis and Laurell immunoelectrophoresis. Rabbit antipepsinogen I serum cross-reacted with the mouse preparation but did not with the rabbit and porcine preparations. The possibility of the genetically controlled occurrence of pepsinogens I and II in the rat is discussed.

Amino Acids↗
PubMed1980

Role of adrenergic agonists on gastric secretion in the rat.

Following previous demonstration that isoproterenol stimulated and norepinephrine inhibited gastric acid secretion induced by secretagogues, role of adrenergic agonists was studied by measuring acidity the peptic activity of the effluent of the perfused rat stomach. Response of gastric secretion to isoproterenol was increased by theophylline treatment but was not affected by metiamide treatment. N6, O2'-Dibutyryladenosine 3', 5'-cyclic monophosphoric acid sodium salt monohydride (dibutyryl-c-AMP) stimulated gastric secretion in a dose-dependent manner. These results suggest the possibility that the action of isoproterenol in gastric acid secretion is mediated by c-AMP. However, gastric secretion induced by pentagastrin, histamine, or carbamylcholine was not affected by theophylline treatment. N2, O2'-Dibutyrylguanosine 3', 5'-cyclic monophosphoric acid sodium salt (dibutyryl-c-GMP) did not exert any effect on gastric secretion. Depression of pentagastrin-induced gastric secretion by norepinephrine was reversed by EGTA infusion. Moreover, Ca2+, depressed pentagastrin-induced gastric secretion. These results suggest that the action of norepinephrine is closely related to the concentration of Ca2+.

Adrenergic alpha-Agonists↗
PubMed1980

Malignant fibrous histiocytoma of the heart.

A 33-year-old woman presented signs and symptoms which suggested mitral stenosis and insufficiency. Subsequent echocardiographic and angiographic testing demonstrated a left atrial tumor which was suspected clinically to be a left atrial myxoma. At surgery, the tumor was partially resected and histological examination revealed that the mass to be a malignant fibrous histiocytoma. At autopsy, the tumor was found to be localized in the heart, and there was no metastasis.

Adult↗
PubMed1980

Aminotransferase activities and involution of the thymus in rats bearing AH 130 tumors.

Involution of the thymus was observed in rats bearing AH 130 (solid-type) tumors. The thymus weight decreased with tumor growth. Daily injection of a pharmacological dose of hydrocortisone into normal rats resulted in involution of the thymus and marked increase in alanine aminotransferase activity. This treatment also caused slight increase in the activity of tyrosine aminotransferase but not of aspartate aminotransferase in these animals. Involution of the thymus in tumor-bearing rats, however, was not accompanied by appreciable increases in the activities of these aminotransferases, even at an advanced stage of tumor growth when the plasma corticosterone level was very high and significant increase in the activities of all these enzymes was observed in the liver. Further, additional injections of hydrocortisone into rats with tumors weighing more than 5% of the body weight did not cause any appreciable change in alanine aminotransferase activity in the thymus, although in rats with smaller tumors it slightly increased the enzyme activity in the thymus. Furthermore, in normal rats, increase in alanine aminotransferase activity in the thymus with involution of the glands was observed with a dose of corticosterone close to the physiological range attained in rats with tumors in an advanced stage.

Alanine Transaminase↗
PubMed1980

Factors contributing to the prognosis of falciparum malaria.

Factors contributing to the poor outcome of imported falciparum malaria in adult patients were investigated and following conclusions were drawn. 1) In the case of primarily non-immune patients, a catastrophic course of the disease was precipitated when the inception of treatment was delayed beyond 6 days after the onset of illness. Nine fatal and 3 moribund cases presently reported fell in this category. However, there were exceptional cases who made an uneventful recovery, despite the delay in starting treatment, apparently due to appropriate treatment taken immediately upon confirmation of the grave situation. 2) The group of fatal and moribund cases usually had higher parasite and lower thrombocyte counts that the groups of patients who ran a favorable course. Exceptional cases were also seen: a moribund or a fatal case with a rather low parasite count or a satisfactorily recovered case with a high initial parasite count. 3) Abnormal kidney function was seen in all the fatal and moribund cases while the incidence was low or nil in the patients who ran a favorable course. 4) The patients with a past history of malaria or in recrudescence usually ran a smooth course despite the delay in the inception of treatment which was initiated beyond the second week of illness.

Adult↗
PubMed1980

[A case of large germinoma in bilateral frontal region (author's transl)].

Though most of ectopic pinealoma occurs in the midline of cerebral base, only ten cases of frontal subcortical germinomas were reported in Japan as far as we know in literature. The patient, 20 year-old male, was admitted to our hospital because of blurred vision of the right eye and somnolence. Neurological examination on admission revealed bilateral choked discs and impaired visual acuity of both eyes with visual field defect of the right eye. A large deep bifrontal tumor was noted by cerebral angiography and pneumoventriculography done at the time of ventricular drainage. After subtotal removal of left frontal tumor and bifrontal V-P shunt, he came alert. No abnormality of posterior part of third ventricle was noted on the post-operative pneumonencephalogram. As the microscopic examination revealed that the tumor was germinoma of two-cell pattern, Co60 with a total dose of 5,900 rads was irradiated to the rest of the tumor. Brain scan with Tc99m 6 months after the surgery showed the disappearance of the tumor and CT scan 3 years later confirmed no recurrence of the tumor. Fine structure of the tumor was also presented and discussed.

Adult↗
PubMed1979

Purification and characterization of rat pepsinogens whose contents increase with developmental progress.

Two pepsinogens, the contents of which increase with developmental progress, were purified from the gastric mucosa of the adult rat by ammonium sulfate fractionation and chromatography on DEAE-cellulose and DEAE-Sepharose CL-6B columns. The purified zymogens, designated as pepsinogens I and II, were each shown to be homogeneous by polyacrylamide gel disc electrophoresis. Pepsinogen II had a greater electrophoretic mobility toward the anode at pH 8.0 than pepsinogen I. The molecular weights of both zymogens were estimated to be 38,000 by SDS-polyacrylamide gel electrophoresis. The activated enzymes, pepsins I and II, each had the same molecular weight of 32,000. The pH optima for both enzymes were found to be 2.0. The enzymes showed high stabilities at pH 8.0, while they lost their activities within 60 min at pH 10.0. The enzymes were inhibited by pepstatin and diazoacetyl-DL-norleucine methyl ester (DAN). The activities of the enzymes in hydrolyzing N-acetyl-L-phenylalanyl-3,5-diiodo-L-tyrosine (APDT) were about 1/8 of that of porcine pepsin. These results suggest that pepsins I and II are very similar.

Animals↗