Search PubMed⌕ Search

Biomedical subjects

S Sawada

Publications and source records attributed to S Sawada.

At least 523 records · Page 29Linked to original sources
PubMed1983

Measurement of regional lung blood flow by videodensitometry.

The pulmonary blood flow in patients with embolism, emphysema or a tumour of the lung was measured by videodensitometry in 27 lungs from 17 patients. The results suggest that the relative regional and total lung blood flow can easily be estimated. It is also easy to demonstrate abnormalities in the distribution of the lung blood flow. The mean transit time in the normal lung is considered to be 1.5 to 4 seconds.

Absorptiometry, Photon↗
PubMed1983

Localized fatty infiltration of the liver. CT demonstration of its disappearance on treatment.

Two cases of localized fatty infiltration of the liver are reported, each of which demonstrated localized, well demarcated, abnormal low attenuation at computed tomography (CT), and were indistinguishable from malignant hepatic tumor. Following intravenous administration of contrast medium, normal blood vessel architecture within the low attenuation area was clearly demonstrated at CT. About three months thereafter, the fatty infiltrations had disappeared completely at CT following treatment of the underlying disease.

Adult↗
PubMed1983

Right ventricular aneurysms complicating encephalomyocarditis virus myocarditis in mice.

Inbred strains of BALB/c, C3H/He and DBA/2 mice were inoculated intraperitoneally with the M variant of encephalomyocarditis virus with a titer of 100 TCD50 per 0.1 ml and followed up to the 8th month. Right ventricular aneurysms were noticed in 7 hearts of these 647 mice (1.1%) sacrificed from 8 to 10 months after inoculation with the virus. Myocardial fibers of the right ventricle were destroyed transmurally and fibrosis was found in the chronic stage. This study demonstrated that viral myocarditis may cause right ventricular aneurysms, albeit infrequently, suggesting a pathogenetic role of viral infection in right ventricular dysplasia or Uhl's anomaly.

Animals↗
PubMed1983

Unusual monoclonal DNA binding immunoglobulin.

The monoclonal antibodies directed against DNA were produced by somatic cell hybridization with parental cells (SP-2) and spleen cells from nonimmunized autoimmune MRL/lpr mice. The immunoglobulins were recovered from the culture supernatant from hybridoma by a solid immunoadsorbent and antibody immunoprecipitation. The results from the specificities of DNA binding monoclonal immunoglobulins suggest that the antibodies to DNA have the antibody combining sites for both epitope of double stranded helix and base of DNA and support the concept of the multiple antigen binding potentials of the hybridoma autoantibodies.

Animals↗
PubMed1982

Excitatory actions of homocysteic acid on hippocampal neurons.

The actions of D- and D,L-homocysteate (DH and DLH) on CA3 neurons were studied in thin sections of the guinea pig hippocampus. DH and DLH administered to the stratum radiatum induced large depolarizations in CA3 neurons. The responses to DH and DLH were accompanied by increases in membrane conductance. The amplitudes of the responses increased and decreased, respectively, during tonic hyperpolarizing and depolarizing currents. In neurons injected with Cs+, these responses were reversed in polarity at membrane potentials of -13 to -19 mV. These results indicate that receptors for homocysteate in the hippocampus have different properties from those found in the spinal cord and are quite similar to glutamate receptors.

Animals↗
PubMed1982

Sensitivity of hippocampal neurons to glutamic acid and its analogues.

In thin slices of the guinea-pig hippocampus, depolarizations induced by glutamate (Glu) and its analogues were studied by intracellular recording. It was found that Glu induced stereospecific responses, that L-Glu was more potent than homocysteate and N-methyl-D-aspartate. It is probable that the high-affinity uptake mechanism played a decisive role in termination of L-Glu excitation.

Animals↗
PubMed1982

Stereochemistry of proton abstraction catalyzed by lysine and ornithine omega-aminotransferases.

(6R)-L-[6-3H]Lysine and (6S)-L-[6]3H]lysine were prepared to investigate the stereochemical aspects of the reaction catalyzed by bacterial L-lysine epsilon-aminotransferase. When (6R)-L-[6-3H]lysine was used as a substrate, the tritium label was retained in the product, delta 1-piperideine-6-carboxylate. In contrast, the radioactivity from (6S)-L-[6-3H]lysine was found in the solvent. Thus, the pro-S hydrogen at the prochiral C-6 carbon of L-lysine is specifically abstracted by L-lysine epsilon-aminotransferase. The proton exchange was observed by proton nuclear magnetic resonance analysis in the reaction of bacterial L-ornithine delta-aminotransferase with L-ornithine in 2H2O. The isolated L-[5-2H]ornithine was converted to dextrorotatory 4-phthalimido[4-2H]butyrate. This indicates that L-ornithine delta-aminotransferase catalyzes the stereospecific exchange of the pro-S hydrogen at the prochiral C-5 carbon of L-ornithine with the solvent.

Binding Sites↗
PubMed1982

On the pathophysiology of left ventricular aneurysm. An analysis by cineangiography and videodensitometry.

In 16 patients with left ventricular aneurysm, ventriculography has been performed and recorded upon videotape. By means of videodensitometer the ejection fraction of the total ventricle and its parts have been analysed. The videodensitometric result explained the ejection fraction pattern which is caused by the moment of the contrast medium in different parts of the ventricle. The regurgitation phenomenon in the contractile and non-contractile parts of the ventricle is explained by a turbulent movement of contrast medium between the different parts of the ventricle. This turbulence should be included in the criteria of a left ventricular aneurysm.

Absorptiometry, Photon↗
PubMed1982

Encephalomyocarditis virus myocarditis in inbred strains of mice--chronic stage.

Inbred strains of A/J, BALB/c, C3H/He, C57BL/6 and DBA/2 mice were inoculated with the M variant of encephalomyocarditis virus having a titer of 100 TCID50/0.1 ml. Myocardial lesions were seen in 73 of 150 BALB/c mice (48.7%), 160 of 259 C3H/He mice (61.8%) and 115 of 174 DBA/2 mice (66.1%). No pathologic findings were noted in A/J and C57BL/6 mice. In C3H/He and DBA/2 mice, dilatation and hypertrophy of the heart accompanying myocardial lesions persisted up to the 8th month after virus inoculation. The present study revealed that myocardial lesions similar to those in congestive (dilated) cardiomyopathy persisted for a long period after viral infection.

Animals↗