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Biomedical subjects

S Roy

Publications and source records attributed to S Roy.

At least 883 records · Page 49Linked to original sources
PubMed1977

Diagnosis of pregnancy with a radioreceptor assay for hCG.

A new serum assay for human chorionic gonadotropin, the radioreceptor assay (RRA), was compared with three commercial urinary agglutination inhibition pregnancy tests (AITs) in a group of women with suspected early pregnancies and ectopic gestations. The accepted definitions by which a laboratory test is characterized, including clinical sensitivity and specificity as well as predictive value of positive and negative tests and efficiency, were calculated for each test in three different time periods of gestation: less than 7 days, between 7 and 14 days, or more than 14 days after the expected menses had been missed. The results of the study showed that the RRA had greater clinical sensitivity and efficiency than the AITs in cases of both early gestation and ectopic pregnancy. The RRA has the disadvantages of requiring the capability to handle radioactive materials and gamma counter. This test is chiefly useful for those patients desiring early termination of pregnancy and those infertility patients anxious for early confirmation of pregnancy.

Chorionic Gonadotropin↗
PubMed1976

Third ventricular chromophobe adenoma with normal adenohypophysis.

An unusual case of chromophobe adenoma occurring in the third ventricle is reported. Ventriculography revealed a filling defect in the third ventricle and at autopsy the tumour was found in the posterior part of the third ventricle. No tumour was detected in the pituitary gland.

Adenoma, Chromophobe↗
PubMed1976

Management of painful shoulder.

55 patients with 60 shoulders painful at rest, and with limitation of all ranges of movement, were treated with multiple injections of methylprednisolone acetate into the subacromial space and glenohumeral joint cavity. Pain was abolished in 80%, two weeks after starting therapy and 95% were pain-free four weeks after the first injection. Maximum functional recovery (at least 150 degrees abduction, 80 degrees internal rotation, and 45 degrees external rotation), was achieved in 90% of patients eight weeks after starting treatment. It is suggested that the "frozen" shoulder--i.e., pain-free shoulder with severe limitation of all movement--is the end result of a neglected painful shoulder and it is essential that painful shoulders be treated as early as possible if normal function is to be preserved.

Adult↗
PubMed1976

Sickle-cell disease and poststreptococcal acute glomerulonephritis.

The cases of three children with sickle-cell hemoglobinopathy and acute poststreptococcal glomerulonephritis are described and discussed. Light and electron microscopic findings in three cases, and immunofluorescence microscopic findings in two are described. Since proliferative glomerulonephritis of either poststreptococcal or non-poststreptococcal etiology may be seen in patients who have sickle-cell disease, immunofluorescence and/or electron microscopic examination is essential for accurate diagnosis.

Acute Disease↗
PubMed1976

Morphological types of hepatocellular hyalin in Indian childhood cirrhosis: an ultrastructural study.

Morphological variants of intrahepatocytic hyalin in Indian childhood cirrhosis have been analysed by electron microscopy. This structure, morphologically identical with Mallory's alcoholic hyalin, is encountered in three different forms. The most common one is composed of randomly oriented fibrils. The next common type is composed of smudgy homogeneous or finely granular material, while the least common type consists of parallel fibrils with gentle curves giving a 'finger-print' appearance. Fragmented endoplasmic reticulum and ribosomes were frequently associated with hyalin suggesting that these organelles contribute to their formation.

Child↗
PubMed1976

Prognosis of acute poststreptococcal glomerulonephritis in childhood: prospective study and review of the literature.

Serial, clinical, clinicopathologic and histologic studies performed simultaneously following onset of PS-AGN in children for a period of up to 144 months revealed no evidence of progression to chronic glomerulonephritis. Although acute morphologic changes were more severe in renal tissue obtained from patients with AGN following streptococcal upper respiratory infection than following pyoderma, the acute manifestations in both groups subsided 6 to 12 weeks after onset. Cumulative morphologic healing occurred in 20% of patients at 24 months, in 43% at 48 months after onset of PS-AGN; 1 patient who was unhealed at 49 months was lost to follow-up. In 2 patients (6%), acute histologic exacerbations without clinical signs occurred within 24 months after onset. Subsequent healing was documented histologically. Addis counts remained abnormal in a high percentage of patients throughout the 12 years of observation and did not correlate with the histologic findings of renal biopsy tissue. The occasional demonstration of renal vascular disease and/or hypertension may merely reflect the early development of spontaneous essential hypertension although the possibility of a relationship to the previous attack of PS-AGN is intriguing. This question cannot be answered at this time. Renal biopsy studies are more dependable than Addis counts in assessing the course of PS-AGN. The significance of persistence of immunofluorescent and/or electron microscopic changes (subepithelial dense deposits) many years after onset in 58% of 12 patients studied, at a time when a majority of patients (84%) revealed healing by light microscopy, remains to be assessed.

Acute Disease↗