Biomedical subjects
Publications and source records attributed to S Roy.
A case of multiple primary tumors in a 12-year-old girl is described. The tumors included a right optic nerve glioma, a pilocytic astrocytoma in the right globus pallidus, a ganglioglioma in the left globus pallidus and a medulloblastoma in the cerebellum. To our knowledge no such case has been reported so far in literature.
Sixteen specimens of pituitary adenoma were studied by electron microscopy. Twelve of them were "non-functioning" tumours and four were associated with acromegaly. All the tumours showed the light-microscopic appearance of classical chromophobe adenoma. Though electron microscopy revealed varying degrees of granularity in the majority of the cells in all the tumours, two distinct morphological types of chromophobe tumours were observed. In one type, secretory granules were frequently seen in moderate or large numbers and the cells were poor in RER and Golgi apparatus. These cells are considered to be secretorily inactive storage cells and they were the predominant cells in eight cases of "non-functioning" adenomas. The other type was noted in four cases of "non-functioning" adenomas and in all the four cases of adenoma with acromegaly. In this type, the tumour cells were generally poor in secretory granules but were rich in RER and Golgi apparatus, suggesting secretory activity. In acromegaly these features appear to indicate active hormone synthesis and its discharge into the circulation but the reason for the morphological evidence of active secretion in the four cases of "non-functioning" adenoma is not clearly understood.
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Short courses of cyproterone acetate, a compound with progestational and antiandrogenic activities, were administered to normally menstruating women during different phases of the menstrual cycle to suppress growth and maturation of the follicles and corpus luteum function. Postovulatory administration of 20 mg of the drug daily for 8 days to two women delayed menstruation by 4 to 6 days, followed by prolonged bleeding and short post-treatment cycles. Plasma levels of progesterone were suppressed temporarily during therapy, but increased immediately after cessation of treatment. Administration of 10 mg of the drug for 8 days during the early follicular phase to two women resulted in irregular bleeding, short cycles, and decreased plasma levels of progesterone throughout the cycle. Reduction of the dose to 2.5 mg during the early follicular phase in two other women also resulted in irregular cycles. When the 2.5-mg dose was administered to three women from the 8th to the 15th days of the cycle, vaginal bleeding and cycle length were normal. Plasma levels of luteinizing hormone and progesterone were suppressed during therapy. In one subject, cervical mucus was found to be hostile to sperm penetration in all three treatment cycles. The results indicate that, with cyclic administration of low doses of cyproterone acetate to women during the late follicular phase, it may be possible to interrupt pituitary-ovarian function, as well as sperm transport through the cervical mucus.
A case of diffuse cerebral cysticercosis is described. The case is of interest because the involvement of brain was extensive and bilateral but electro-encephalographically unilateral periodic epileptiform complexes were recorded on 3 different occasions. Possible mechanisms of these lateralised periodic epileptiform discharges are discussed.
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The in vitro incorporation of E1U-C14]-glucose by ampullary and isthmic segments of the Fallopian tube and the uterus was determined in the intact (estrous), ovariectomized, ovariectomized plus estrogen and ovarietcomized plus estrogen + progesterone treated rabbit. In the intact animal the ampulla incorporated glucose at a faster rate than the isthmus; uterine uptake is minimal. Ovariectomy reduced the rate of incorporation below normal values in all the tissues. EDP (estradiol dipropionate) administered to ovariectomized rabbit increased the incorporation rate. Progesterone antagonized the EDP-induced uptake. The relative rate and pattern of incorporation by the three tissues were, however, determined by the dosage of estrogen and the estrogen/progesterone ratio.