Biomedical subjects
Publications and source records attributed to S Roy.
This report documents the recurrence of dense deposit disease in a renal allograft thirty-three days post-transplantation and stresses the usefulness of immunofluorescence in early detection.
A randomized single-blind clinical study was performed to determine whether there was any difference in the termination event rates between parous women using the Ypsilon-Y intrauterine device (IUD) and those using the Lippes loop D. A total of 174 women received the Ypsilon-Y IUD and 173 women received the loop D. A significant higher incidence of expulsion occurred with use of the Ypsilon-Y IUD.
Changes in the morphology and steroid content of ovaries were studied after 48 h of intravenous injection of 100 microgram of cyproterone acetate or flutamide to diestrus or estrous rats. Treatment with cyproterone acetate at diestrus caused a decrease in the number of small follicles (less than 200 micrometer), freshly formed corpora lutea and the levels of estradiol-17beta in the ovary, suggesting inhibition of ovulation. Following flutamide administration at diestrus, the number of follicles at all stages of development were reduced with a concomitant decrease in the ovarian levels of the hormones. Thus, flutamide suppressed the growth and maturation of follicles. On administration of these drugs at estrous, the steroid content of ovaries was more pari passu with the increase in the number of mature and medium follicles. The differential effects of the two drugs are discussed in the light of these observations.
A young man who had a long history of sinusitis developed subarachnoid hemorrhage and died. Autopsy showed a mycotic aneurysm of fungal origin at the junction of the right posterior cerebral and internal carotid arteries. Four of five reported cases of fungal aneurysm were due to Aspergillus infection.
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Hyperimmune rabbit antisera antisera against group A streptococci precipitate protein antigens present in the urines of patients with poststreptococcal AGN and other glomerulopathies and also present in normal human serum. Over 90% of patients with AGN excrete detectable amounts of cross-reactive antigens in their urines, as do approximately 20% of patients with nonstreptococcal glomerulopathies. The streptococcal antigens are present in culture supernates, and immunodiffusion reactions in agar gel show identity or partial identity of serum, urine, and streptococcal antigens with antisera prepared against either urine proteins or against whole group A streptococci. Cross-reactive antibodies are removed from rabbit antisera by absorption with streptococcal culture supernates but not by absorption with a variety of streptococcal somatic constituents. The cross-reactive antigens have been isolated from streptococcal cultures grown in synthetic medium, thus eliminating the possibility of artefact due to tissue antigens present in Todd-Hewitt broth. The principal antigens have now been purified both from AGN urine and streptococcal supernates by molecular sieve and ion-exchange chromatography. They both have a molecular weight of approximately 360,000 daltons, as estimated on columns of agarose. The urine antigen has been applied to SDS-PAGE, and the migration of the major band was consistent with a molecular weight of 85,000 daltons. Rabbit antiserum to purified urine antigen precipitates both AGN urine and streptococcal supernates. These newly recognized human antigens, which cross-react with group A streptococcal antigens, are of particular interest because of their presence in readily available biologic fluids and their preferential excretion in almost all patients with poststreptococcal AGN.
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Hemoglobinuria occurred in two children following severe beating. The development of transient oliguria in one child and acute renal failure in the other emphasizes the importance of early recognition of these unusual complications in the syndrome of child abuse. Appropriate therapy should be given to prevent or lessen the severity of acute renal failure in this clinical situation.
An improved statistical method for assessing the efficacy of intrauterine contraception is presented. This method, called the log-rank method, is based on a daily life table, which yields the best estimates of the cumulative net termination probabilities. It provides a sensitive chi-square test statistic to detect differences among these probabilities for two or more contraceptive devices. When three or more devices are compared, the chi-square statistic may be partitioned into additive components representing comparisons among groups of devices. The log-rank method also permits adjusting for differences among subgroups by controlling for factors such as parity or age. Although calculations may be performed on a desk calculator, a FORTRAN-IV computer program is made available to interested researchers.
A study was performed to obtain additional information about the effects of oral contraceptives on pituitary function. A sequential pituitary stimulation test (SST) was used to study normal control women who then received either a combination pill with 50 mug of ethinyl estradiol or an injectable or oral progestin for three weeks, after which the test was repeated. The same test was also performed on five long-term oral contraceptive users. The SST consists of measurement of growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) at frequent intervals after stimulation by hypoglycemia, thyrotropin-releasing hormone, and gonadotropin-releasing hormone. GH and TSH release following stimulation were unaffected by the use of contraceptive steroids, while PRL release was increased by both the combination pill and the progestin alone. LH and FSH release was decreased in the three short-term and most of the long-term users of the combination pills but was not decreased in two of the long-term users as well as in those receiving the progestin alone. These results indicate that the combination oral contraceptives have a direct effect upon the pituitary gland, causing an increase in prolactin release and a decrease in gonadotropin release. This effect varies among individuals receiving the same formulation and may be related to the development of syndrome of postpill amenorrhea-galactorrhea.
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