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Biomedical subjects

S Reddy

Publications and source records attributed to S Reddy.

At least 289 records · Page 16Linked to original sources
PubMed1981

Malignant metastatic disease of the eye: management of an uncommon complication.

Twenty-four patients with metastatic cancer of the choroid were seen in the Department of Therapeutic Radiology, Rush-Presbyterian--St. Luke's Medical Center, Chicago, between 1964 and 1975. One fourth of the patients had involvement in both eyes, for a total of 30 eyes involved with metastatic cancer. The most common site of the primary carcinoma was the breast. Most of the patients had inadequate vision, proptosis, pain, heaviness, and double vision. Retinal detachment was a common finding. All the patients received a palliative course of radiotherapy to the posterior chamber of the eye; between 2100--3000 rad in 7/10 fractions were given. Of the patients, 33% had complete recovery of symptoms, and 37% had only partial recovery; 30% showed no response to therapy. Survival period from the time of radiotherapy to death varied from one to 21 months, with a median of four months and a mean of 6.6 months. All patients responding to therapy showed marked improvement in their quality of life until death.

Adult↗
PubMed1980

Results of re-irradiation for cerebral metastases.

After an initial course of radiation, 56 patients with cerebral metastases had their brain retreated at least once for recurrent neurologic symptoms. The most common primary was from either the lung or breast. The frequent symptoms were headache, weakness, seizures, visual problems, and/or mental changes. Forty-two (75%) of these patients responded to the second course of treatment. The median duration of response was 10 weeks and median survival was 14 weeks.

Adult↗
PubMed1980

Extranodal non-Hodgkin's lymphoma.

From 1964 to 1977, 42 patients with Stages I and II non-Hodgkin's lymphoma involving the extranodal sites were seen and treated with curative intent by radiotherapy in the Department of Therapeutic Radiology at Rush-Presbyterian-St. Luke's Medical Center. The initial pathologic specimen was reclassified according to the criteria of Rappaport et al. Diffuse histology was the most common histologic type found in 80% of the patients. The five-year actuarial survival and disease-free survival rates were found to be almost identical at 74% for Stage I and 38% for Stage II patients. The most common sites of origin were in the head and neck area in 19 patients and gastrointestinal tract in 15 patients. The sites of involvement in the head and neck area were many and varied, with parotid and nasal cavity being the most frequent. Survival rates and disease-free survival rates for different histologic types, various sites, and their patterns of recurrence are presented.

Gastrointestinal Neoplasms↗
PubMed1980

Ovine placental lactogen in the cotyledonary and intercotyledonary placenta of the ewe.

Antibodies raised against purified ovine placental lactogen were used to demonstrate the cellular localization of the hormone in tissues of the ewe placenta and chorionic membranes by immunofluorescence and immunoperoxidase techniques. Although binucleate cells have been shown to appear as early as Day 16 of pregnancy, ovine placental lactogen was not detected in the trophoblast until Day 22, and in substnatial numbers of cells until Day 80, of gestation. In the more mature placenta, lactogen-immunoreactive material was demonstrated in (a) binucleate cells of the fetal trophoblast, (b) uninucleate cells associated with the maternal epithelium syncytium and (c) binucleate cells of the chorionic membranes.

Animals↗
PubMed1979

Pattern of recurrences in endometrial carcinoma and their management.

During the period 1961-1971, 177 surgical candidates with clinical Stage I adenocarcinoma of the endometrium were treated. The pattern of recurrence according to the initial mode of treatment and the high risk factors predisposing to recurrence are presented. The incidence of vaginal vault recurrence was reduced from 7.4% with surgery to 1.2% by the use of adjunctive radiotherapy. Management of recurrence according to site is outlined. The local control rate for patients with local recurrence was 44% and the five-year survival rate after recurrence was 33%.

Adenocarcinoma↗
PubMed1978

Continuous measurement of tissue pH in the human fetal scalp.

A method for continuous measurement of scalp tissue pH is described. The tissue pH probe was found to be robust and values for tissue pH were close to those for scalp blood pH. Combining the pH and fetal heart fate (FHR) electrodes in the one mechanical assembly facilitated application to the fetal scalp in early labour but the combined assembly electrode was found to have some disadvantages and manufacture of a separate tissue PH electrode is recommended. Continuous monitoring of scalp tissue pH enables closer study of the physiological basis of changes in fetal acid base status and should prove useful to the obstetrician in management of high risk pregnancies during labour.

Female↗
PubMed1978

Purification and some properties of ovine placental lactogen.

A method has been described for the purification of ovine placental lactogen (oPL) involving the use of freshly obtained sheep foetal cotyledons. Tissue was extracted with 0.1 M-ammonium bicarbonate and the supernatant fraction, adjusted to pH 7, was brought to 60% saturation with ammonium sulphate. The resulting precipitate was then subjected to a sequence of chromatographic steps using columns of Sephadex G-100 and carboxymethylecellulose. During each stage of the purification, the lactogenic activity was monitored with a pregnant rabbit mammary gland radioreceptor assay. The yield of oPL corresponded to 8 mg/kg wet foetal tissue and the oPL possessed lactogenic activity equivalent to 1 mg ovine prolactin/mg protein and GH-like activity equivalent to 0.8 mg human GH/mg protein. The biological activity of oPL was confirmed using a rabbit intraductal mammary gland assay in vivo. After polyacrylamide gel electrophoresis at pH 8.9, oPL was resolved into one major band (isoelectric point 8.2--8.4) and four minor components, which were thought to be deamidation products of oPL. Microimmunoelectrophoresis and immunodiffusion studies confirmed that the preparation of oPL was free from serum protein contaminants.

Animals↗
PubMed1977

Early nodal and extra-nodal non-Hodgkin's lympnomas.

There were 54 Stage I and 38 Stage II patients with non-Hodgkin's lymphomas treated with curative radiotherapy between 1964 and 1975. The initial biopsy material was reclassified according to the criteria of Rappaport el at.10 The frequency of nodular vs diffuse histological pattern was 26% vs 74%. The survival and recurrence free survival were significantly superior for the nodular pattern as compared with diffuse in both Stages I and II. The sites of first recurrence were evaluated. Fourteen out of 20 Stage I and 18 out of 26 Stage II patients recurred in one of the nodal areas only as their first site of recurrence. In 50%, this was in contiguous lymph node areas only. Extra-nodal non-Hodgkin's lymphomas survival and recurrence-free survival rates at five years were identical.

Biopsy↗
PubMed1975

Arthropod-borne viral infections of man in Nigeria, 1964-1970.

During the years 1964 to 1970, 171 arboviruses of 15 different types were isolated from humans in Nigeria. Isolation rates were highest in 1969, and lowest in 1965 and 1967. Monthly arbovirus activity was highest in the rainy season months of June, July and August and lowest in the dry months of January and February. Viruses were isolated from all age groups, with the majority from children one to four years old. The viruses isolated in largest numbers were chikungunya and yellow fever, which caused epidemics in 1969, and dengue types 1 and 2 and Tataguine, which are endemic in Ibadan. Bwamba virus was isolated in 1964 and 1969, and Bunyamwera group viruses were encountered for the first time in 1969. Other viruses recovered less frequently were Zika, Igbo-Ora (an agent related to o'nyong-nyong), two viruses related to the Uganda mosquito virus Ug MP 359, Dugbe, Thogoto, Lebombo and Shuni. Several of these are new agents and have not previously been isolated from man. Clinical details are presented where available.

Adolescent↗
PubMed1975

Metrifonate in urinary schistosomiasis. A field trial in northern Nigeria.

A field trial of metrifonate in the form of Bilarcil tablets (Bayer) was carried out in 39 northern Nigerian schoolchildren heavily infected with Schistosoma haematobium. Three oral doses of 7.5 mg/kg were given at four-week intervals. The drug proved effective (mean reduction in egg counts eight weeks after completion of treatment 94.5%) and was excellently tolerated. Its use on a larger scale is suggested.

Administration, Oral↗