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Biomedical subjects

S Reddy

Publications and source records attributed to S Reddy.

At least 307 records · Page 17Linked to original sources
PubMed1975

Distribution of radioactivity in tissues after the intravenous injection of free and acrylic particle bound-porcine 125I-neurophysin-I into rats and rabbits.

Porcine neurophysin-I iodinated with Na125I was injected intravenously into rats and rabbits, and the rate of disappearance of radioactivity from the peripheral system was measured. Radioactively-labeled neurophysin bound to polymethylmethacrylic particles was similarly infected into the animals. The half-time for the loss of radioactivity from samples of whole blood was 6.1--6.4 min as determined over the first 5 min after administration of the protein. There was no significant difference in the half-time calculated when the radioactivity present in the trichloroacetic acid-insoluble material present in the se-um was measured. 15 min after the injection of labeled protein there was a maximum and massive uptake of radioactivity in the kidney consistent with this tissue's being important in the degradation of neurophysin. Immunoperoxidase histochemical techniques were applied to formalin-fixed kidney slices and demonstrated the presence of neurophysin-like material localized in the cells of proximal tubules of the cortex and medulla. On binding neurophysin to acrylic particles there was approximately a 10-fold increase in the uptake of radioactivity in the lungs and a 33% reduction in activity in the kidneys, as measured at the 15-min time interval. Of the other tissues studied, excluding the thyroid gland and lungs, the uterus demonstrated the greatest uptake of radioactivity of fat tissue had the least accumulation of radioactive label.

Animals↗
PubMed1975

Uptake of 125-I-labelled human placental lactogen and human placental lactogen by the tissues of normal and lactating rats.

The rate of clearance from the circulation and uptake into tissues of radioactive label was studied after i.v. injection of 125-I-labelled human placental lactogen (HPL) into rats at various stages of pregnancy. The half-life was obtained for the disappearance of the trichloroacetic acid-precipitable material from the plasma. The half-life, t1/2(S), calculated over the first 5 min after injection of the hormone was 5.4 equals or minus 1.1 (S.D.) min, while a half-life, t1/2(L), of 27.9 equals or minus 2.3 min was obtained from the decay period of 15-35 min. In the non-pregnant and pregnant rat the highest ratio of the radioactivity in an organ to that in the blood was 12-14:1 in the kidney. That the kidney is mainly involved in the uptake of exogenous HPL is further confirmed by the application of the histochemical immunoperoxidase technique. Human placental lactogen was localized in the cells of the proximal tubules of the cortex and to a lesser extent in the tubular lumen and the tubules of the medulla region. UPTAKE OF HPL in vivo occurs in the mammary gland tissue of the post-partum rat and reaches a maximum uptake between 15 and 30 min after injection of the hormone. Furthermore, specific uptake of HPL was observed on the alveolar cell membranes after the incubation of paraffin-embedded sections of formalin-fixed mammary gland and subsequent treatment by the peroxidase-labelled antibody method. These findings support the work of others who have demonstrated the presence of specific membrane receptors in the mammary gland for hormones with prolactin-like activity.

Absorption↗
PubMed1971

Rheumatic heart disease in children in developing countries.

The features of rheumatic heart disease in 31 Nigerian children aged 5-11 years are presented. The majority of these children sought medical attention when they were in advanced cardiac failure. In approximately 23% of the children a past history of acute rheumatic fever was obtained. It is suggested that in developing countries, skin ulcers may be as important a focus of beta-haemolytic streptococcal infection as the throat is in developed countries in the aetiology of acute rheumatic fever. Rheumatic heart disease in developing countries present two main problems, namely, diagnosis and management including prophylaxis. The differential diagnosis of rheumatic heart disease in some tropical countries and the factors which affect the management of the disease are discussed.

Cardiomyopathies↗
PubMed1970

Immunity, transferrin, and survival in kwashiorkor.

In a study of 40 children with kwashiorkor, serum albumin, transferrin, and immunoglobulin levels were measured. Treatment included chloroquine, pyrimethamine, multivitamins, folic acid, iron compounds, and a high-protein diet. After two weeks the mean serum transferrin values in the children who survived and those who died were 1.30 mg./ml. and 0.33 mg./ml., respectively. Many of the children died immediately after treatment started, and it is suggested that in children with severe kwashiorkor and low serum transferrin levels any increase in free-circulating iron may result in overwhelming infection and death. Thus the appropriate time for instituting iron therapy in such patients should be reconsidered.

Child, Preschool↗