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Biomedical subjects

S Ozsoylu

Publications and source records attributed to S Ozsoylu.

At least 235 records · Page 13Linked to original sources

A case of hemolytic anemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency.

A propositus, the offspring of a first-cousin marriage, was presented with severe hemolytic anemia, splenomegaly, jaundice, and growth retardation. Marked basophilic stippling of erythrocytes was shown by Wright's stain. Erythrocyte 5'-nucleotidase activity was found markedly decreased, whereas red blood cell glucose-6-phosphate dehydrogenase activity was elevated as the reduced glutathione level. His growth and anemia improved following splenectomy. His sister was also similarly affected.

5'-Nucleotidase↗

Levamisole treatment in acute hepatitis.

Fifty-six and forty patients with acute icteric hepatitis were given levamisole and placebo, respectively, for the first 3 days of a week of the disease for 2 weeks, and continued through the third and fourth weeks if their hepatitis was not resolved. Liver functions of the levamisole-treated patients became normal slightly faster than the controls'. The normalization time of transaminases was found barely significantly shorter in the levamisole-treated group than in the controls (p less than 0.05). Additional studies with larger groups of antigenetically different types of hepatitis are warranted to determine whether treatment with levamisole might lessen the chances of developing chronic hepatitis.

Acute Disease↗