The symptoms of two children with erythromelalgia were relieved promptly by the intravenous administration of sodium nitroprusside (1-5 micrograms/kg/min). The elevated blood pressure of one of them was also easily controlled with this drug and did not recur during the follow-up period. Taken together with our previous experience, we believe sodium nitroprusside administration to be a treatment of choice for erythromelalgia, in which the constant pain and burning sensation make the patient extremely restless.

Adolescent↗

PubMed1984

High dose intravenous glucocorticoid in the treatment of childhood acquired aplastic anaemia.

31 children with acute acquired aplastic anaemia were treated with very high doses of i.v. bolus methylprednisolone. In 3 of them, paroxysmal nocturnal haemoglobinuria was diagnosed. Therefore the responses of 28 patients have been evaluated. Normoblastaemia and reticulocytes were observed on about the 6th d and leucocyte and granulocyte response around the 11th d of treatment. The first haemoglobin (greater than or equal to 0.5 g/dl) and haematocrit elevations were documented on about the 16th d and the initial platelet response (average greater than or equal to 34 X 10(9)/l) took more than a month. At least 64% of the patients responded to this treatment including 2 cases in whom aplasia was observed following hepatitis. Although 10 episodes of recurrences occurred in 8 patients (with the exception of 3 patients' in whom 5 recurrences were observed), response to the same regimen was obtained. With 1 exception the side-effects of this treatment could be managed by decreasing the dose. With this treatment, acquired aplastic anaemia should no longer be considered a fatal disease, at least in children.

Anemia, Aplastic↗

PubMed1984

Bolus methylprednisolone therapy in chronic idiopathic thrombocytopenic purpura in children.

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Adolescent↗

PubMed1984

High-dose intravenous corticosteroid for a patient with Diamond-Blackfan syndrome refractory to classical prednisone treatment.

A 2.5-year-old boy with congenital pure red cell aplasia (PRCA) became unresponsive to conventional prednisone (2 mg/kg) treatment following a febrile period related to diphtheria-pertussis-tetanus (DPT) immunization and required transfusions. Following an administration of high-dose intravenous methylprednisolone, his bone marrow and hematological findings were completely normalized and continued so for 18 months after initiation and 9.5 months after discontinuation of the treatment. When his anemia relapsed, following an upper respiratory infection, he was again found refractory to conventional prednisone administration but responded promptly to intravenous bolus methylprednisolone treatment.

Anemia, Aplastic↗

PubMed1983