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Biomedical subjects

S Ozsoylu

Publications and source records attributed to S Ozsoylu.

At least 253 records · Page 14Linked to original sources
PubMed1980

Effect of intravenous adrenalin infusion and corticosteroid treatment in patients with von Willebrand's disease.

Intravenous adrenalin infusion (5 micrograms/kg, at most 160 micrograms in 10 min) normalized partial thromboplastin time (PTT) and ristocetin induced platelet aggregation (RIPA) in 4 of the 14 patients with von Willebrand's disease (VWD) in a short period of time. Although mean factor VIII (F-VIII) procoagulant activity was almost doubled 5 min following infusion, this was mainly observed in patients with relatively high baseline (> 2%) AHF activity. Mean F-VIII procoagulant activity rose by more than 100% following 10 days of corticosteroid treatment (deltacortil 2 mg/kg/day, at most 60 mg/day). PTT became normal in 6 of the 11 patients, but RIPA normalized only in 2. The improvement of RIPFA did not correspond to bleeding time in every patient. These results may suggest that if the baseline AHF activity is relatively high (greater than or equal to 9.5%), corticosteroid could be tried before schedule surgical intervention in patients with VWD.

Adolescent↗
PubMed1979

Familial cirrhosis.

Three pairs of siblings with cirrhosis were investigated. The histopathological examination of the liver biopsy specimens and the laboratory findings did not give any clue about the cause of the disease. The presence of familial cirrhosis was considered.

Adolescent↗
PubMed1978

Hemoglobin S and some other hemoglobinopathies in Eti-Turks.

Frequencies of various hemoglobinopathies were examined in a total of 1,922 individuals of Eti-Turk origin by electrophoretical techniques. Hemoglobin A2 (Hb A2) and hemoglobin F (Hb F) determinations were also performed in 651 and 1,642 cases, respectively. Mean hemoglobin S (Hb S) frequency was found to be 15.3%. Variations among the different age groups were insignificant. Hemoglobin E (Hb E) and beta-thalassemia frequencies wer 0.47 and 1.23%, respectively. Hemoglobin Hacettepe and hemoglobin D were found once. Red cell glucose-6-phosphate dehydrogenase (G6PD) deficiency was found in 6.5% of males.

Adolescent↗
PubMed1978

Thrombocytopenic purpura related to rubella infection.

Serologic studies for rubella (hemagglutination inhibition and complement fixation changes) were carried out at two-week intervals in 15 patients with acute idiopathic thrombocytopenic purpura and in age-matched controls in the same season during a small rubella epidemic. Hemagglutination inhibition, sucrose density gradient for hemagglutination inhibition, and complement fixation titer changes implicated recent rubella infection as an etiologic factor in five of the 15 patients.

Adolescent↗
PubMed1978

Hyperinsulinemia in childhood cirrhosis.

Circulating insulin was determined by radioimmunoassay in ten children with cirrhosis of the liver and in 6 age-matched controls. They were found to be elevated in cirrhotics during fasting as well as at 1/2, 1, 1 1/2 and 2 h during the oral glucose tolerance test. These determinations were also carried out in two children with extrahepatic portal hypertension to show the possible role of portal systemic shunts for the elevated serum insulin levels. We believe that the hyperinsulinemia of these patients was related to decreased insulin degradation by the liver as well as to portal-systemic shunting.

Adolescent↗
PubMed1977

Functional development of phagocytic activity of the spleen.

The improvement of phagocytic activity of organs was studied in rats by means of 99mTc sulfur colloid uptake. This function was measured in the newborn rat, 1-, 2-, 3-, and 4-week-old baby rats and in adult rats. Organ distribution of the 99mTc-S-colloid showed marked phagocytic activity of the liver in all age groups including the newborn period. Phagocytosis in bone marrow was markedly increased and that in spleen markedly decreased at the time of birth. However, rapid improvement of phagocytic activity with age was prominent in the spleen.

Animals↗