Elevation of PAIgG on intact and lysed platelets in the case unresponsive to intravenous gammaglobulin.
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Biomedical subjects
Publications and source records attributed to S Ozsoylu.
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A 10-year-old classic hemophiliac and 1.5-year-old child with hemophilia B who developed acute lymphocytic and acute myelomonocytic leukemia respectively are presented. No changes in coagulation status of the patients were observed. It is suggested that hemophiliacs should be regarded as "population at risk" for the development of leukemia.
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Administration of propranolol to 13 children with portal hypertension reduced splenic pulp pressure by greater than 50 mm H2O (P less than 0.01) in approximately 2 weeks, when the pulse rate became three fourths the initial rate. The influence was found to be greater in compensated than in decompensated portal hypertension. This observation might be interpreted to mean that the effect of propranolol in the reduction of portal venous pressure results not only from decreased intestinal blood flow secondary to decreased cardiac output but also to the stimulation of sympathetic nervous system alpha-adrenoreceptors of the portal tract. Although arterial blood pressure changes were not significant, peripheral venous pressure was reduced significantly (P less than 0.01). We conclude that propranolol has considerable usefulness in treating portal hypertension in children.
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Globin chain synthesis was performed with the peripheral blood of a 10-year-old girl, who had acquired aplastic anaemia, at the time of bolus methylprednisolone administration and during recovery. There was no indication of an increase in gamma chain synthesis despite elevation of total foetal haemoglobin.
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