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Biomedical subjects

S Olsson

Publications and source records attributed to S Olsson.

At least 91 records · Page 5Linked to original sources
PubMed1988

Anaphylactic reactions to cinoxacin.

During 1981 to mid-1988 three cases of anaphylactic shock after treatment with the quinolone derivative cinoxacin were reviewed by the Netherlands Centre for Monitoring of Adverse Reactions to Drugs and 17 cases of an anaphylactic type of reaction notified to the World Health Organisation Collaborating Centre for International Drug Monitoring. In five out of six patients for whom data were available the reaction began shortly after taking a single capsule of a second or next course of treatment. Cinoxacin is related to nalidixic acid, and one patient previously treated with that agent subsequently had an anaphylactoid reaction to cinoxacin and later developed a skin reaction to nalidixic acid. There were no deaths, and patients treated as an emergency with plasma expanders or with adrenaline and corticosteroids generally recovered promptly and uneventfully. In view of the potentially fatal consequences of anaphylactic reactions to cinoxacin and other quinolones doctors should take care when prescribing these drugs.

Adrenal Cortex Hormones↗
PubMed1988

Determination of the rate of release of intra-oral mercury vapor from amalgam.

The experimental and analytical difficulties associated with the measurement of mercury vapor in the oral cavity are considerable. In the present paper, the objective was to measure the amount of intra-oral mercury vapor in subjects with amalgams, by means of two sets of equipment based on different functional principles. In addition, it was found that the type of mercury source prevalent in the oral cavity had to be evaluated. The measuring technique used to obtain correct results is discussed, and an evaluation of the conditions for the application of the measuring equipment available was made. It was found that the amount of mercury released from the oral cavity was time-dependent. Furthermore, the amount of mercury released with the time kept constant was almost independent of the pumping flow rate up to 8 L/min. It was found that the tissue, saliva, and the amalgam restorations were not depleted of mercury during the measuring time. The results of the Mercollector-Mercometer measurements carried out on seven subjects with nine or more occlusal surfaces restored with dental amalgam and on three subjects without any amalgam restorations revealed that the rate of mercury release was in the range 0.03-0.34 ng/sec in the former group and less than 0.01 ng/sec in the latter. Based on the experimental results and on theoretical considerations, it was concluded that the amount of mercury released per time unit is the only quantity measurable.

Adult↗
PubMed1988

A new instrument for mercury vapor evacuation during clinical work with dental amalgam.

Clinical work with dental amalgam, cutting as well as filling and polishing operations, results in an increased level of mercury vapor in the breathing zone of the patient and often also in that of the dentist. The mercury levels can be minimized by the use of a high volume evacuator which is handled by the nurse. Since many dentists cannot count upon continuous chairside assistance during work with dental amalgam a new instrument, combining the functions of a common dental mirror and an evacuator has been developed. The aim of the present work was to evaluate the mercury vapor evacuating capacity of the new instrument. The study was carried out in a model box especially designed for the in vitro tests performed. The amount of mercury in an area representing the patient's breathing zone was recorded directly and indirectly using an equipment based on atomic absorption spectrophotometry. The results revealed that the new instrument has the capacity for substantially reducing the mercury levels during filling, polishing and cutting amalgam. Thereby the short transitory exposure to mercury vapor during certain working moments can be reduced which should be beneficial both to the patient and to the dental staff.

Air Pollutants, Occupational↗
PubMed1987

Agar impression materials, dimensional stability and surface detail sharpness following treatment with disinfectant solutions.

The influence of seven dissimilar disinfectants on the dimensional stability and the surface detail sharpness of two agar impression materials was studied. Two methods for treatment with disinfectant solutions were tested--immersion for 1 hour and spraying. In contrast to immersion the spraying method had no obvious influence on the agar material. It is concluded that if the disinfection method necessitates immersion of the impression in a solution for 1 hour or more the use of agar impression materials should be avoided.

Agar↗
PubMed1986

Lack of association between hemochromatosis and alpha-antitrypsin deficiency.

alpha 1-Antitrypsin (AAT) deficiency of phenotype PiZ and idiopathic hemochromatosis (IH) predispose to the development of cirrhosis and liver cell carcinoma. Several reports have suggested an association between these two inborn errors. To elucidate this question we used a monoclonal antibody against the PiZ gentic variant of AAT to analyze and compare the PiZ gene frequency in an area (county of Jämtland in Central Sweden) with a high, and another area (the city of Malmö in Southern Sweden) with a low IH prevalence. The PiZ gene frequencies did not differ between the areas. We also analyzed sera from 27 unrelated adult males with hemochromatosis diagnosed in the high IH area for the presence of the PiZ gene product but none was a carrier of the PiZ allele. These findings strongly refute any association between. AAT deficiency and IH.

Adult↗
PubMed1985

Reference values for exercise tests with continuous increase in load.

Reference values for exercise tests with continuous increase in load are presented. The exercise tests were performed on an electrically braked bicycle ergometer by 188 randomly selected Swedes of both sexes who were between 20 and 79 years of age. The reference values are related to sex, age (in decades) and weight and classified in decreasing levels of exercise capacity. Reference values for systolic blood pressure at different work loads are also given.

Adult↗
PubMed1985

Alginate impression materials, dimensional stability and surface detail sharpness following treatment with disinfectant solutions.

A study was made of the influence of six dissimilar disinfectants on the dimensional stability and the surface detail sharpness of four alginate impression materials. All combinations of alginates and disinfectant solutions produced quite acceptable results as regards dimensional stability one hour after the impression material had been sprayed with the disinfectant. As regards surface detail sharpness one hour after this spraying certain combinations of alginates and disinfectant solutions showed better results than others. Immersion of the alginates in disinfectant solutions for one hour or more produced unacceptable changes.

Alginates↗
PubMed1982

Therapeutic equivalence of sulfaisodimidine 2 g twice daily and 1 g four times daily in lower urinary tract infections.

The serum concentrations and clinical effects of sulfaisodimidine given during 12 days were examined in two groups of patients with uncomplicated lower urinary tract infection. Group I (n=12) received the drug in a conventional dosage, 1 g four times daily, and group II (n=14) in a dose of 2 g twice daily. The serum concentrations of sulfonamide at steady state (day 7) and one day after cessation of therapy (day 13) did not differ significantly between the groups. With the exception of one patient in group I, both subjective and objective symptoms vanished during treatment and remained absent for at least 4 weeks thereafter. Two patients in each group developed signs of sulfonamide allergy. Thus, the two regimens seemed to be equally efficient, and the risk of therapy failure due to low blood concentrations of sulfaisodimidine should not be greater when the drug is given in a dosage of 2 g twice daily than when it is administered in the conventional way. Hence, the latter, simpler regimen can be recommended.

Adult↗
PubMed1981

Comparison of diflunisal and acetylsalicylic acid in patients with rheumatoid arthritis.

A double-blind comparison of the clinical efficacy and tolerance of varying doses of diflunisal (DFS) and acetylsalicylic acid (ASA) was carried out in 15 patients with rheumatoid arthritis who were given no other antirheumatic medication. An effort was made to select appropriate anamnestic, functional and sociofunctional tests and to optimize their validity by careful measurements performed by the same specialized physiotherapist and occupational therapist. In addition, the serum concentration of DFS and salicylic acid were monitored by high-pressure liquid chromatography. The therapeutic effects of DFS was at least as good as that of ASA. Moreover, DFS was better tolerated; all 7 patients on DFS could sustain the maximum dose (1g) of this drug, while that of ASA (4g) was tolerated by only one of 8 patients. All these experienced side effects, necessitating drug withdrawal in 3 cases, one being a serious hepatotoxic reaction. DFS treatment, on the other hand, was associated with only one minor side effect. The side effect difference was statistically significant (p less than 0.01). The analyses of drug concentrations in serum verified that all patients were exposed to DFS and ASA as planned, adding safety to the judgement of the therapeutic effects. The findings support the view that the novel salicylic acid derivative DFS may offer a therapeutic advantage in the treatment of rheumatoid arthritis; it seems to have at least the same therapeutic effect as ASA an may be better tolerated.

Adult↗
PubMed1981

Positive contrast herniography in adult patients with obscure groin pain.

To evaluate its clinical benefit in adults, herniography was used in 73 patients with clinically unexplained groin pain. Hernias were demonstrated on the side with symptoms in 26 patients (36%). Relief of groin pain was registered in 16 of 17 patients who subsequently underwent operation. We consider herniography to be of value in the examination of adult patients with clinically unclear groin pain.

Adult↗
PubMed1980

The uptake of 14C-chloroquine by mouse pancreatic islets in vitro.

The uptake of 14C-chloroquine by isolated mouse pancreatic islets in vitro was investigated. The islets were found to have a very high capacity to accumulate the substance. The uptake of 14C-chloroquine in the islets was a saturable process. Metabolic inhibitors, ouabain, anaerobic conditions and absence of glucose did not inhibit the uptake of 14C-chloroquine in the islets, suggesting that the substance is accumulated by some means other than energy-dependent active transport or pinocytosis. The uptake of 14C-chloroquine was inhibited by low temperature and low pH and in the presence of mepacrine, chlorpromazine, imipramine and desmethylimipramine. Only a small part of the 14C-chloroquine which had been taken up in the islets left the cells during 45 min. incubation in non-radioactive media. Two possible mechanisms for the uptake of 14C-chloroquine in the islets are considered: (1) The accumulation may be due to a binding of the substance to cellular constituents. (2) Chloroquine may be trapped by protonation within lysosomes or other membrane-surrounded organelles with low pH.

Absorption↗