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Biomedical subjects

S Noda

Publications and source records attributed to S Noda.

At least 289 records · Page 16Linked to original sources
PubMed1984

Effect of high doses of synthetic estrogen on lipid metabolism in castrated male rats.

The mechanism by which high doses of estrogen influences lipid metabolism was studied with a microtubular blocking agent. Castrated male rats received oral injection daily for 14 days of 3 mg hexestrol in olive oil, or oil alone as controls. About half of the animals in each group were injected intraperitoneally with 4 mg/100 g body weight colchicine 3 hr before they were killed. Hexestrol treatment caused an accumulation of esterified cholesterol in the liver while it decreased those in serum. Triglyceride concentrations slightly decreased in the liver but were unaffected in serum. On polyacrylamide-gel disc electrophoresis, the peaks of high density lipoproteins (HDL) and low density lipoproteins (LDL) were decreased remarkably. Electron microscopic examination of hepatocytes revealed electron-lucent lipid droplets in the cytoplasm. After a colchicine treatment of the control animals, concentrations of esterified cholesterol and triglycerides markedly increased in the liver, while those in serum decreased. Electron microscopic examination of hepatocytes revealed numerous secretory vesicles filled with nascent VLDL. In hexestrol-treated animals, the colchicine treatment was associated with marked decreases in serum-esterified cholesterol and triglyceride as seen in the controls. However, there were no further increases of esterified cholesterol in the liver, and the increase of triglycerides was slight. Electron microscopic examination showed less secretory droplets than in the controls. These data suggest that very low density lipoproteins (VLDL) synthesis in the liver of hexestrol treated rats was inhibited. An accumulation of esterified cholesterol with a marked decrease in serum could not be accounted for by the inhibition of lipoproteins secretion, but rather by their enhanced entry into the liver.

Animals↗
PubMed1984

Correlation between the direction of the interventricular septum estimated with transmission computed tomography and the initial QRS vectors.

A correlative study was performed to relate the interventricular septal angle (As degrees) evaluated by transmission computed tomography to the azimuth of initial QRS vectors in 52 patients. Patients were divided into five groups: RV volume overloading (RVO), RV pressure overloading (RSO), LV volume overloading (LVO), LV pressure overloading (LSO), and normal control with no cardiopulmonary disease. For measurement of As degrees, the leftward and forward directions were designated as zero and 90 degrees, respectively. The mean value of As degrees was significantly smaller in RVO (14.4 degrees) and RSO (41.1 degrees) than in normal controls (50.4 degrees) and in LVO (53.2 degrees). The mean value of the azimuth of the initial 12-msec instantaneous QRS vectors (H 12 degrees) was significantly smaller in RVO (80.5 degrees), RSO (81.7 degrees), and LSO (81.3 degrees) than in normal controls (113.8 degrees and in LVO (113.7 degrees). A significant linear correlation was shown between As degrees and H12 degrees in a combined group consisting of RVO, LVO, and normal controls (r = 0.70, p less than 0.001), and also in another combined group consisting of RSO, LSO, and normal controls (r = 0.52, p less than 0.01). It was concluded that the orientation of the interventricular septum was one of the major determinants of the direction of initial QRS vectors, especially in patients with ventricular volume overload or without cardiopulmonary disease.

Adolescent↗
PubMed1984

Development of Onchocerca volvulus larvae in Simulium pintoi in the Amazonas region of Venezuela.

The intake and development of Onchocerca volvulus in Simulium pintoi from the Parima mountain region of the Federal Territory of Amazonas in Venezuela, were studied experimentally. When wild females fed on the lower half of the legs and lower third of the back of an onchocerciasis patient harboring 23 and 264 microfilariae per skin snip, respectively, at each site, an average (median) of 14 (range, 1-77) and 245 (range, 58-495) microfilariae was ingested. However, within 24 hours of microfilarial ingestion a mortality of 47% (16/34 flies) was observed in the group of flies which fed on the back, as compared with 2% (2/101 flies) in the other group which fed on the legs. At a temperature varying between 16 degrees C and 24 degrees C, the development of O. volvulus larvae in S. pintoi was synchronous and orderly; no abnormal nor deformed larvae were observed. Third-stage larvae were first seen in the head of flies dying between 8 and 9 days after microfilarial ingestion, and 98 of 100 larvae recovered from days 10-16 were in the third stage. The proportions of females harboring third-stage larvae among flies which lived through day 8 in the two groups which fed on the legs and back, respectively, were 55% (21/38 flies) and 63% (5/8 flies). Although only two of five positive flies in the latter group contained third-stage larvae in the head (1 and 12, respectively), 71% (15/21 positive flies) of the former group had an average of 2.7 third-stage larvae in the head (range, 1-10).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

[Malignant fibrous histiocytoma of the scrotum].

A 72-year-old man was hospitalized for a gradually enlarging left scrotal mass. Physical examination revealed a 3 X 4 cm. rock hard non-tender mass fixed to adacent tissue. The tumor invaded the skin of scrotum and showed ulcer formation. Surgical therapy was performed under the diagnosis of left scrotic tumor. The resected mass was examined histologically, and the pathologic diagnosis was of malignant fibrous histiocytoma of the left scrotum was made.

Aged↗
PubMed1984

On mechanism of urate kidney stone formation.

Experimental hyperuricemic kidney and urate kidney stone were made in rats, and the mechanism of urate stone formation was investigated at electron microscopic level. Continuous hyperuricosuria caused first the microcrystal, probably a stone embryo, in the distal tubule. In the surroundings of the crystal there were wandering and infiltration of numerous polymorphonuclear leucocytes which, in the distal tubule, showed phagocytosis of enlarged urate crystal and encircled the crystal. These results suggested that the polymorphonuclear leucocytes greatly contribute to an increase of urate crystal with continuous hyperuricosuria. The urate crystal in the collecting tube, expanded and flowed down, and progressed two ways; one stayed, occluded and developed to stone in the duct and the other was released from the papilla opening into the duct to be excreted.

Animals↗