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Biomedical subjects

S Mukherjee

Publications and source records attributed to S Mukherjee.

At least 379 records · Page 21Linked to original sources
PubMed1984

Tardive dysmentia: a reappraisal.

The proposed concept of tardive dysmentia is reassessed with critical comments on methodological issues. The probability that this type of behavior is related to the disease process in chronic schizophrenia has not been ruled out. If tardive dysmentia were to be a result of neuroleptic exposure primarily, it should also be seen in neuroleptic-treated nonschizophrenic patients. In a study of tardive dyskinesia among bipolar patients, we failed to notice any cases that could have been described as tardive dysmentia as proposed. This suggests a strong possibility of this syndrome being illness related rather than neuroleptic caused. Finally, the syndrome appears to be more of a dyscontrol than a dysmentia . Tardive dyscontrol may be a better term than dysmentia . There is no evidence that these patients would fit criteria for a diagnosis of mania, and the proposal that these patients may be mistakenly diagnosed as manic is unfounded.

Antipsychotic Agents↗
PubMed1984

Lichen simplex chronicus during lithium treatment.

A patient who was taking lithium developed an intensely pruritic lesion that remitted after lithium discontinuation and recurred with readministration. The condition was successfully treated with local steroid application, which permitted continuation of lithium maintenance.

Administration, Topical↗
PubMed1984

Aspartate aminotransferase increases in crevicular fluid during experimental periodontitis in beagle dogs.

A ligature-induced periodontitis model employing the beagle dog was used to study the levels of aspartate aminotransferase (AST) in crevicular fluid before and after ligation. A significant increase in AST level occurred in crevicular fluid 2 weeks after ligation whereas no increase of enzyme was found in serum. Enzyme levels in crevicular fluid were 10- to 100-fold higher than in serum. Dental plaque did not appear to be the source of the enzyme. Since aspartate aminotransferase has been documented as a marker of cellular injury arising during heart disease and liver disease, this study suggests that aspartate aminotransferase, in like fashion, reflects cellular damage arising from active periodontal disease.

Animals↗
PubMed1984

Neurological abnormalities in patients with bipolar disorder.

A test for agraphaesthesia and the face-hand test were administered to 75 DSM-III bipolar disorder patients. Twenty-five patients (33.3%) had abnormal findings on these tests. Abnormal findings were limited to the group of 54 patients with a history of long-term neuroleptic exposure. There was a strong correlation between the duration of cumulative neuroleptic exposure and the presence of abnormalities. In the group with long-term neuroleptic exposure, family history of affective disorders was negatively correlated with the presence of abnormalities. It appears that long-term neuroleptic exposure may be a contributory causal factor in the development of abnormal neurological signs in bipolar patients. A tendency toward more left-hand errors suggesting hemispheric integration dysfunction was noted in the patients exposed to long-term neuroleptics.

Adult↗
PubMed1984

The efficacy of ECT in phencyclidine-induced psychosis.

Four patients are described who had a history of PCP abuse, prolonged psychosis, and poor neuroleptic response. Three of these patients were given ECT; all showed a dramatic response after the third or fourth treatment. The authors recommend that ECT be tried in psychotic patients who have used PCP if they fail to respond to antipsychotic medications after 1 week of inpatient treatment.

Adolescent↗
PubMed1983

Differential survival and chloramphenicol-insensitive error-prone repair of hydroxylamine-inactivated phi X174 bacteriophage mutants.

Features of inactivation, repair and concomitant mutagenesis of hydroxylamine-treated phi X174 bacteriophages are reported here. (1) For reasons unknown, the nonsense phage mutants tested here were far more sensitive to hydroxylamine than the wild-type phage. In contrast, the sensitivities of these same phi X174 mutants to UV-irradiation are indistinguishable. (2) Hydroxylamine-treated amber phages mutated to ochre but not to wild-type particles, i.e., G leads to A transition events were recovered. (3) The repair of phi X174 phages from hydroxylamine-induced damage was error-prone, but unlike UV damage, did not require protein synthesis de novo. Possible mechanisms of these novel features are discussed.

Bacteriophage phi X 174↗
PubMed1983

A double-blind placebo-controlled study of fluvoxamine and imipramine in out-patients with primary depression.

1 A double-blind placebo-controlled study of fluvoxamine and imipramine was performed in a group of depressed patients. Twenty-two patients received fluvoxamine (mean dose 101 mg/day), 25 received imipramine (mean dose 127 mg/day) and 22 received placebo. 2 Apart from an increase in the SGOT and SGPT values of four imipramine patients, no statistically significant changes in haematology or urinalysis were judged to be medically relevant. Fluvoxamine exhibited fewer anticholinergic side effects than imipramine. 3 Both fluvoxamine treated patients and imipramine-treated patients exhibited a statistically significant improvement at the end of the 28-day treatment period with respect to the placebo patients, as measured using the Hamilton Rating Scale for Depression, and the Clinical Global Impression Scale. Evaluations of the results of the Beck Depression Inventory and the Profile of Mood States revealed a statistically significant improvement for imipramine patients with respect to placebo at week 4, but not for fluvoxamine patients. It is postulated on the basis of quantitative pharmaco-EEG findings, that the slight superiority of imipramine over fluvoxamine was due to underdosing of the latter.

Adult↗
PubMed1983

Misdiagnosis of schizophrenia in bipolar patients: a multiethnic comparison.

The records of 76 bipolar (DSM-III) patients were reviewed for a history of previous misdiagnosis of schizophrenia. Multivariate analyses identified three variables significantly associated with previous misdiagnosis--auditory hallucinations, early age at onset, and ethnicity. Ethnicity remained significantly associated with misdiagnosis of bipolar patients as schizophrenic even after all other significant variables were partialled out of the equation. It appears from these data that black and Hispanic (Puerto Rican) bipolar patients may be at a higher risk than whites for misdiagnosis as schizophrenic, particularly if they are young and experience auditory hallucinations during affective episodes.

Adult↗
PubMed1982

Tardive dyskinesia in psychiatric outpatients: a study of prevalence and association with demographic, clinical, and drug history variables.

We examined 153 psychiatric outpatients, on a maintenance regimen of neuroleptics, for tardive dyskinesia (TD) and parkinsonism. Demographic, clinical, and drug history data were collected to assess whether any of these factors were significantly associated with TD. After initial univariate screening, significant variables were analyzed by multivariate statistical methods. Tardive dyskinesia was significantly associated with the use of high-potency or high-dosage neuroleptics and depot fluphenazine, whereas low-potency neuroleptics were negatively correlated with moderate TD. Age, but not sex, correlated significantly with TD, as did histories of incoherence, grandiose delusions, and teeth or denture problems. Parkinsonism and TD were strongly associated. Although the prevalence of TD was quite high, there were no severe involvements of any of the Abnormal Involuntary Movement Scale body areas.

Age Factors↗