Search PubMed⌕ Search

Biomedical subjects

S Miyazaki

Publications and source records attributed to S Miyazaki.

At least 739 records · Page 41Linked to original sources
PubMed1984

A trial of adjuvant combination chemoimmunotherapy for stage III carcinoma of stomach.

A chemoimmunotherapy program designed on the basis of experimental results was administered to 27 patients with stage III carcinoma of stomach following curative resection. The treatment regimen consisted of active immunotherapy with Vibrio cholerae neuraminidase (VCN)-treated autologous tumor cells admixed with bacillus Calmette-Guérin (BCG) and chemotherapy with drugs such as cyclophosphamide (CY), mitomycin C (MMC), and 5-fluorouracil (FU) which proved to enhance the immune response when administered at optimal dose and timing. Then, it was followed by long-term administration of tegafur (FT) and immunomodulators. This treatment significantly improved survival when compared to that of 41 historical control patients treated with surgery alone (P less than 0.001). As compared to 31 control patients concurrently treated with a bolus dose of MMC followed by long-term FT and immunomodulators, survival had a tendency, but not significantly, to be improved in patients treated with this therapy (P less than 0.1). However, the survival rate at 4.5 years was significantly higher than that of control patients (P less than 0.01). These results appeared to show that this type of adjuvant combination chemoimmunotherapy may be of benefit for this group of patients with gastric carcinoma.

Adult↗
PubMed1984

Immunodepression after surgery: impaired production of interleukin 2.

The capacity of peripheral blood mononuclear cells to produce interleukin 2 (IL 2) was studied serially before and after various surgical procedures in 34 patients. In the group of 6 patients who had minor surgery and were categorized into class 1, IL 2 activity did not differ significantly from the preoperative value, throughout the postoperative course. In the group of 14 class 2 patients who underwent major surgery, however, significant decreases in IL 2 activity were observed 1, 3 and 6 days after operation as compared to findings before surgery. Preoperative levels were reverted to by the 8th postoperative day. The remaining 14 patients underwent major and extensive surgical procedures, and were put into class 3. Here too, were also significant decreases in the activity 1, 3 and 6 days after operation. The activity remained significantly depressed 8 days after surgery, in this group of patients. These results show that depression in the production of IL 2 in postoperative surgical patients correlates relatively well with the extent of the surgical procedures.

Animals↗
PubMed1984

Combination chemoimmunotherapy for advanced gastric carcinoma.

Eighty-nine patients with advanced gastric carcinoma were treated with a combination chemo-immunotherapy regimen that consisted of active immunotherapy with Vibrio cholerae neuraminidase (VCN) treated autologous tumor cells admixed with BCG and drugs including cyclophosphamide, mitomycin C (MMC) and 5-fluorouracil, followed by long term tegafur (FT) and immunomodulators. This treatment significantly improved survival rate of patients in Stages III, IV and unresectable or recurrent carcinoma, compared to that of historical controls. As compared to controls treated with MMC followed by long term FT and immunomodulators concurrently, survival rate of those in Stage III tended to improve (P less than 0.1) and survival rate at 4.5 years in Stage III was significantly higher (p less than 0.01), although it was not improved in Stage IV. In patients with unresectable or recurrent tumor, survival time was not significantly lengthened with this therapy when compared with that in patients given BCG alone in the same treatment schedule (CCI-BCG group). However, none of 19 patients in CCI-BCG group survived more than 15 months, although 4 of 28 patients receiving this therapy survived. These results suggest that this combination chemo-immunotherapy is effective for a selected group of patients with advanced gastric carcinoma.

Adjuvants, Immunologic↗
PubMed1984

Aneurysm at the origin of the accessory middle cerebral artery.

An aneurysm at the junction of the accessory middle cerebral artery and the horizontal portion of the anterior cerebral artery is reported. The importance of this anomalous artery is discussed with regard to the genesis of aneurysms of the anterior cerebral artery.

Adult↗
PubMed1984

A dissecting aneurysm of the vertebral artery.

A rare case of dissecting aneurysm of the vertebral artery evidenced by ischemic attacks is reported. The aneurysm was treated by proximal ligation of the artery. There have been no repeated ischemic attacks and bleeding for 20 months. Analysis of 51 cases of vertebral artery aneurysm failed to disclose any comparable case. A review of the literature also revealed that clinically diagnosed dissecting aneurysms of the vertebrobasilar system have been reported rarely. Most of these cases were found at autopsy.

Aortic Dissection↗
PubMed1984

Carcinoma of the stomach in a 7-year-old boy--a case report and a review of the literature on children under 10 years of age.

Carcinoma of the stomach in childhood is exceedingly rare. We now report on a case of carcinoma of the stomach in a 7-year-old Japanese boy, the youngest with so-called adult-type carcinoma of the stomach in Japan. The tumour was located mainly in the cardial region. Total gastrectomy was performed and an oesophago-jejunostomy was constructed. Histological studies revealed an anaplastic adeno-carcinoma. The possibility of gastric malignancy should always be considered when gastro-intestinal symptoms persist, even in children.

Adenocarcinoma↗
PubMed1984

Development of human fetal muscles: a comparative histochemical analysis of the psoas and the quadriceps muscles.

The development of human muscle can be divided into three distinct phases on the basis of the enzyme histochemistry (Dubowitz 1965). On the other hand, muscles can be classified into trunk muscles innervated by the motoneurons in the anteromedial nucleus of the anterior horn and limb muscles innervated by those of the lateral nucleus. We compared histochemically the development of the psoas muscle as a trunk muscle with the quadriceps. Four legally aborted fetuses and sixteen autopsied preterm or full-term infants with conceptional ages ranging from sixteen to fourty-two weeks, served as subjects. Serial crossly cut frozen sections of the psoas and the quadriceps were stained with HE, modified Gomori-trichrome, NADH-TR, myofibrillar ATPase (routine, preincubation at pH 4.6, 4.3), and analyzed quantitatively. In the psoas and the quadriceps, all muscles consisted of undifferentiated type IIC fibers before the eighteenth week of gestation. Type I fiber began to appear around the eighteenth week in both muscles. Before the thirtieth week, both muscles comprised a great number of smaller type IIC fibers and scattered large type I fibers. The psoas had already a little more type I fibers than the quadriceps in this phase. After the thirtieth week, the percentage of type I fibers increased greatly to about 50% at term in the psoas, gradually to 20-23% at term in the quadriceps. Type IIA and IIB fibers appeared suddenly around the thirty-seventh week. Total percentage of these two type fibers increased at term to about 50% and 70% in the psoas and the quadriceps, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenosine Triphosphatases↗
PubMed1984

Central nervous system complications in childhood leukemia. Correlation between clinical and computed tomographic findings.

We used cranial computed tomography (CT) to evaluate 51 leukemic patients with or without central nervous system (CNS) symptoms. Among 17 symptomatic patients, nine had gross abnormalities on CT scans; leukemic infiltrations, infections (CNS aspergillosis), hemorrhages, and therapy-related complications were all evident. One with a leukemic infiltration showed a periventricular low density on the CT scans. The differential diagnosis of CT findings and the correlation between clinical and CT findings is described. The significance of a low-density area observed in an asymptomatic patient on long-term intrathecal methotrexate therapy for CNS leukemia is also discussed.

Brain↗
PubMed1984

Biological activities of partially purified elastase produced by Flavobacterium meningosepticum.

Injection of viable cells of Flavobacterium meningosepticum at doses of 10(6) colony-forming units/eye caused ophthalmia in rabbits' corneas. Elastase, free of protease activity, was partially purified from broth cultures of F. meningosepticum ATCC12535 and TMS516. The optimum pH of the elastase activity was about 8.0. The activity was suppressed by Ni, Zn, Co, EDTA, and o-phenanthroline, and accelerated by Cu and Fe. The minimum dose of the elastase causing ophthalmia in the eyes of rabbits was 5 micrograms/eye (0.065 elastase units). The minimum lethal dose of the elastase for suckling mice by intracerebral injection was 0.4 micrograms (0.0052 elastase units)/suckling mouse, and its minimum lethal dose for adult mice by intraperitoneal injection was 740 micrograms/mouse (9.52 elastase units).

Animals↗
PubMed1984

High-dose 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitro sou rea hydrochloride (ACNU) with autologous bone marrow rescue for patients with brain stem tumors.

4 patients with brain stem tumors were treated with high-dose ACNU with autologous bone marrow rescue. Hematologic and nonhematologic toxicities were not profound. There was objective evidence of response in 2 out of the 4. All were alive for 11-21 months from onset. Safe administration of high-dose ACNU with marrow rescue will warrant further control studies to determine its superiority over conventional doses.

Astrocytoma↗
PubMed1984

Neurophysiological evaluation of newborns with congenital hydrocephalus.

EEGs and visual and auditory evoked potentials (VEP and AEP) were studied in 27 newborns with congenital hydrocephalus. Asynchronous sleep patterns were the main EEG abnormality in the newborn as well as in the older infants and children. Asynchronous tracé alternant patterns, the most common finding, were more frequently encountered in infants with more severe hydrocephalus. Asynchrony of bifrontal humps was another finding observed in a few infants. Intermittent semirhythmic theta or delta waves were noted in some infants. Depression of the EEG background activity was an infrequent finding observed in more severe hydrocephalus. VEP showed prolonged latency in 60% of cases, but its wave form was normal in most cases, even sometimes in patients with highly abnormal EEGs. Therefore, it can serve as a tool to assess the maturity of such infants. In contrast, AEP was normal in 76% of the cases. The neonatal EEG findings were significantly correlated with the clinical outcome and can be an additional prognostic indicator in congenital hydrocephalus.

Arnold-Chiari Malformation↗
PubMed1984

Assessment of viable myocardium within infarct zone by exercise thallium-201 scintigraphy.

The viability of the myocardial regions corresponding to pathologic Q waves was evaluated. Thirty-four patients with prior myocardial infarction underwent serial thallium-201 scintigraphy during treadmill exercise testing. On the delayed images, 8 of the initial 85 segmental defects (8 patients, 9%) showed total redistribution (RD) and 11 (6 patients, 13%) showed partial RD. In contrast, 66 segments showed persistent defect. The segments with total RD were more likely to be associated with normal or hypokinetic wall motion than the segments with persistent defect (p less than 0.05). Six of the 38 segments (13%) with collateral vessels showed total RD and 10 (21%) showed partial RD. However, 35 of 38 segments (92%) without collateral vessels showed persistent defect. There was a significant difference (p = 0.02) in myocardial thallium uptake patterns when the segments with and without collateral vessels were compared. It is concluded that (1) exercise-induced thallium RD may occur in patients with prior myocardial infarction, and myocardial infarct regions with total RD are highly associated with good contractility; these suggest the presence of viable but jeopardized myocardium within the infarct zone, and (2) collateral vessels may play a role in limiting infarct size.

Adult↗