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Biomedical subjects

S Miyake

Publications and source records attributed to S Miyake.

At least 307 records · Page 17Linked to original sources
PubMed1985

[Clinical experience of latamoxef in the field of neurosurgery on the penetration into the cerebrospinal fluid in the patients with postoperative meningitis].

Latamoxef (LMOX) at a dose of 2 g was intravenously administered to 12 cases with postoperative meningitis and the concentrations in serum and cerebrospinal fluid (CSF) were examined up to 2 hours and the results obtained were as follows; The average serum and CSF concentrations of LMOX were 125.0 micrograms/ml, 4.33 micrograms/ml at 0.5 hour, 80.7 micrograms/ml, 4.64 micrograms/ml at 1 hour and 45.8 micrograms/ml, 3.82 micrograms/ml at 2 hours, respectively. The clinical responses of LMOX against postoperative meningitis were revealed excellent in 4 cases and good in 8 cases. No side effects were observed. LMOX was thought to be effective agent in the treatment of the postoperative meningitis.

Adult↗
PubMed1985

Radioimmunoassay of human plasma apolipoprotein A-1: pretreatment of plasma with guanidine hydrochloride.

A sensitive and specific double antibody radioimmunoassay for apolipoprotein A-1 was first reported by Schonfeld and Pfleger (1). Their procedure required delipidation of the serum since direct radioimmunoassay of apolipoprotein A-1 in untreated sera resulted in much lower values than those obtained from the corresponding delipidated samples. In an attempt to find a rapid and simple procedure for radioimmunoassay of apolipoprotein A-1 without using organic solvents, the serum was subjected to various physical and chemical treatments which disrupt or alter high density lipoproteins (HDL). Heating at 52 C for 3 h and the treatments with 0.1% Triton X-100, 0.05 M sodium dodecyl sulfate (SDS), and 8 M urea resulted in an increased immunoreactivity of apolipoprotein A-1; the reactivity, however, was much lower than that obtained from delipidated samples. Treatment with 6 M guanidine hydrochloride for 3 h at 37 C prior to radioimmunoassay resulted in a maximal increase of apolipoprotein A-1 immunoreactivity comparable to that obtained with delipidated samples. This pretreatment permits a large number of samples to be assayed with complete recovery of apolipoprotein A-1.

Apolipoprotein A-I↗
PubMed1984

A neural network model for the mechanism of feature-extraction. A self-organizing network with feedback inhibition.

We propose a new multilayered neural network model which has the ability of rapid self-organization. This model is a modified version of the cognitron (Fukushima, 1975). It has modifiable inhibitory feedback connections, as well as conventional modifiable excitatory feedforward connections, between the cells of adjoining layers. If a feature-extracting cell in the network is excited by a stimulus which is already familiar to the network, the cell immediately feeds back inhibitory signals to its presynaptic cells in the preceding layer, which suppresses their response. On the other hand, the feature-extracting cell does not respond to an unfamiliar feature, and the responses from its presynaptic cells are therefore not suppressed because they do not receive any feedback inhibition. Modifiable synapses in the new network are reinforced in a way similar to those in the cognitron, and synaptic connections from cells yielding a large sustained output are reinforced. Since familiar stimulus features do not elicit a sustained response from the cells of the network, only circuits which detect novel stimulus features develop. The network therefore quickly acquires favorable pattern-selectivity by the mere repetitive presentation of a set of learning patterns.

Animals↗
PubMed1984

[Clinical studies on cefmenoxine concentration in prostatic tissue and bladder wall].

Clinical studies on cefmenoxime (CMX) concentration in prostatic tissue and bladder wall were made and the following results were obtained. In 40 patients undergoing operation, 1 g of CMX was administered intravenously by bolus technique and CMX levels in peripheral blood, prostatic tissue and bladder wall were examined. The maximum level of prostatic tissue was 35 micrograms/g after 0.41 hour and bladder wall was 62 micrograms/g after 0.37 hour, and T1/2 was 1.41 hours both. CMX, a new broad spectrum cephalosporin, can be considered as one of the highly useful antibiotics for the treatment of postoperative infection.

Cefmenoxime↗
PubMed1983

Effects of calcium antagonists on the electrical alternans of the ST segment and on associated mechanical alternans during acute coronary occlusion in dogs.

Effects of calcium antagonists on the ST alternans and associated mechanical alternans during acute coronary occlusion were examined in anesthetized dogs. The heart rate was fixed by atrial pacing. The intravenous administration of 0.2 mg/kg verapamil attenuated the ST alternans as did 0.5 mg/kg diltiazem. Although these drugs significantly attenuated TQ depression during occlusion, the attenuation was observed after a longer period of occlusion and when the degree of TQ depression was comparable to that during the control occlusion. Nifedipine, 0.03 mg/kg, slightly attenuated the ST alternans, but 0.5 mg/kg dipyridamole had no effect. These results support the idea that slow inward currents are involved in the ST alternans. On the other hand, the mechanical alternans was attenuated in six of 11 dogs. It is probable that factors other than the electrical alternans may also contribute to the mechanical alternans.

Acute Disease↗