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Biomedical subjects

S Mayer

Publications and source records attributed to S Mayer.

At least 163 records · Page 9Linked to original sources
PubMed1981

Involving clinicians in fee collections: implications for improving clinical practice and increasing fee income in a community mental health center.

This paper examines the relationship between a client's payment or non-payment of fees and treatment outcome, diagnosis, and training of the therapist. Clients who pay regularly are more satisfied and have higher goal attainment regardless of diagnosis. A statistical study and clinical case examples are presented which demonstrate that the failure to pay is clinically significant information and that involving clinicians in the fee collection process can improve clinical treatment and increase the agency's fee income.

Accounting↗
PubMed1981

Evaluation of peripheral blood T lymphocytes in renal adenocarcinoma before and after surgical removal of the tumor.

Peripheral blood T lymphocytes were studied in 24 untreated patients with renal adenocarcinoma, 80 per cent of whom had local extension of the tumor. T lymphocytes were evaluated with the total and the active rosette assays, and were further submitted to stimulation by a range of phytohemagglutinin concentrations in vitro. Controls were healthy volunteers tested on the same days as the patients. Total E-rosette forming cells were slightly decreased but the difference compared to controls was not significant. Active rosettes were normal. When present lymphocytopenia affected total E-rosette forming cells. The mean of the log-converted stimulation indexes was reduced significantly in the patient group only when a suboptimal concentration of phytohemagglutinin was used. Total E-rosette forming cells returned to normal 3 weeks postoperatively but lymphocyte reactivity did not improve and active rosette forming cells remained within normal range. Thus, only minor abnormalities of T lymphocytes were disclosed in this study, suggesting functional alterations rather than depletion. Our study confirms that a cancer operation may act as immunotherapy.

Adenocarcinoma↗
PubMed1981

Herpes gestationis and anti-HLA immunization.

The lymphocytotoxicity technique at +15 degrees C and +37 degrees C was used to identify anti-HLA and cold lymphocytotoxic antibodies in sera from two women with herpes gestationis. The degree of severity of the illness was different in the two cases. The more serious case (widespread cutaneous involvement, repeated fetal deaths) had a very powerful anti-HLA-A9 +anti-HLA-B5 antibody (titre 1/1000); the other had less severe skin lesions; she had an anti-HLA-B13 antibody (titre was 1/256). Both cases had cold lymphocytotoxic auto-antibodies.

Adult↗
PubMed1981

Haplotype study. linkage between HLA--A, B, C and Bf alleles: results obtained by different statistical methods.

325 HLA-A, B and Bf haplotypes obtained from family studies were investigated. In addition, 216 of these were tested for HLA-Cw2, Cw4, Cw5. Four different statistical methods were employed to study 2, 3 or 4 loci gametic associations in order to compare the results obtained by these different methods. Our results were then compared with those of other authors who employed similar methods. Piazza's method, used to identify gametic associations, was not able to show any 3 loci associations in our material. The Delta Standard Method employed in conjunction with Factorial Correspondence Analysis was found suitable for the study of chromosomal prevalence in a population.

Complement Factor B↗
PubMed1981

[Linkage between the gene responsible for adrenal hyperplasia caused by 21-hydroxylase deficiency and chromosome-6 short-arm markers].

In six patients from four different families, the study of the genetic markers of te short arm of chromosome 6 allows to confirm the situation of the gene responsible for congenital adrenal hyperplasia by deficiency of 21 hydroxylase. Thanks to the discovery of a recombination of the maternal haplotype in an affected girl. we consider the situation of the pathological gene with regard to that of the glyoxalase I gene. In the families including at least one patient, these studies permit to tract the heterozygotes and to make a very early or even antenatal diagnosis.

Adrenal Hyperplasia, Congenital↗
PubMed1980

Dephosphorylation and activation of exogenous glycogen synthase by adipose-tissue phosphatase.

Exogenous purified rabbit skeletal-muscle glycogen synthase was used as a substrate for adipose-tissue phosphoprotein phosphatase from fed and starved rats in order to (1) compare the relationship between phosphate released from, and the kinetic changes imparted to, the substrate and (2) ascertain if decreases in adipose-tissue phosphatase activity account for the apparent decreased activation of endogenous glycogen synthase from starved as compared with fed rats. Muscle glycogen synthase was phosphorylated with [gamma-(32)P]ATP and cyclic AMP-dependent protein kinase alone, or in combination with a cyclic AMP-independent protein kinase, to 1.7 or 3mol of phosphate per subunit. Adipose-tissue phosphatase activity determined with phosphorylated skeletal-muscle glycogen synthase as substrate was decreased by 35-60% as a consequence of starvation. This decrease in phosphatase activity had little effect on the capacity of adipose-tissue extracts to activate exogenous glycogen synthase (i.e. to increase the glucose 6-phosphate-independent enzyme activity), although there were marked differences in the activation profiles for the two exogenous substrates. Glycogen synthase phosphorylated to 1.7mol of phosphate per subunit was activated rapidly by adipose-tissue extracts from either fed or starved rats, and activation paralleled enzyme dephosphorylation. Glycogen synthase phosphorylated to 3mol of phosphate per subunit was activated more slowly and after a lag period, since release of the first mol of phosphate did not increase the glucose 6-phosphate-independent activity of the enzyme. These patterns of enzyme activation were similar to those observed for the endogenous adipose-tissue glycogen synthase(s): the glucose 6-phosphate-independent activity of the endogenous enzyme from fed rats increased rapidly during incubation, whereas that of starved rats, like that of the more highly phosphorylated muscle enzyme, increased only very slowly after a lag period. The observations made here suggest that (1) changes in glucose 6-phosphate-independent glycogen synthase activity are at best only a qualitative measure of phosphoprotein phosphatase activity and (2) the decrease in glycogen synthase phosphatase activity during starvation is not sufficient to explain the differential glycogen synthase activation in adipose tissue from fed and starved rats. However, alterations in the phosphorylation state of glycogen synthase combined with decreased activity of phosphoprotein phosphatase, both as a consequence of starvation, could explain the apparent markedly decreased enzyme activation.

Adipose Tissue↗
PubMed1980

[HLA antigens and responsiveness to tetanic toxoid in man].

HLA-A, B, C and Bf antigens were studied in 153 blood donors who developped a titre of greater than or equal to 25 i.u./ml antitetanus antibodies following tetanus anti-toxin vaccination. Antigen frequency was compared with that of 412-464 normal blood donors living in the same area. Few significant differences were demonstrated: absence of Bw21 antigen and slight increase of Bf F antigen were observed in "good responders".

HLA Antigens↗
PubMed1980

[Restimulation of anti-rhesus antibodies and anti-HLA immunization].

Anti-Rh antibodies were restimulated in 32 previously immunized volunteers by injection of small amounts (2 ml) of Rh + fresh blood. The anti-HLA immunization was investigated during this procedure. None of the 10 men developed anti-HLA antibodies. Contrarily 45% of the 22 women showed an anti-HLA antibody before or during the immunization procedure. The HLA type of the husband and of the injected blood was performed to try to explain the specificity of the anti-HLA antibodies.

Antibodies↗
PubMed1980

High frequency of the properdin factor Bf F1 and its linkage to HLA in French Basques.

We studied 201 unrelated French Basque individuals for HLA and Bf polymorphisms. The haplotypes of eighty-seven of them were deduced from family studies. The results show the frequency of the Bf F1 allele (0.1393) which is the highest one currently reported. They confirm the high frequencies of HLA-Aw19.2 and B18 previously reported in that population and show that a whole haplotype with strong linkage disequilibria, namely Aw19.2, Cw5, B18, Bf F1, DRw3 is frequent. On the other hand, the gene frequency of Bf S is decreased (0.5497) as compared with the other European Caucasoïd populations, while a slight increase in the Bf F gene frequency (0.2960) appears. These results point out that it is of importance to consider the genetic background choosing the population where linkage disequilibria are to be studied.

Alleles↗
PubMed1980

Decreased autologous rosette-forming T lymphocytes in alcoholic cirrhosis: absence of correlation with other T cell markers and with delayed cutaneous hypersensitivity.

Autologous rosette-forming T lymphocytes were enumerated in periphal blood of patients with established alcoholic cirrhosis and compared with T lymphocytes forming rosettes with sheep red blood cells (total and 'active' rosette-forming cells; RFC). Decreased autologous RFC was the most frequent T lymphocyte abnormality observed in 43 patients and was shown to occur even in patients with normal total and 'active' RFC. No correlation was found between autologous RFC and total or 'active' RFC. Skin anergy to 2,4-dinitrochlorobenzene was noted in 44% of the patients tested. Autologous RFC did not correlate with delayed cutaneous hypersensitivity to 2,4-dinitrochlorobenzene.

Adult↗
PubMed1979

[Immunoallergic acute haemolysis, thrombocytopaenia and acute renal insufficiency due to treatment with catechines (author's transl)].

The authors report the case of a 25-year-old patient who during discontinuous treatment with a venotropic agent containing catechines suffered from intravascular haemolysis, thrombocytopaenia and acute renal failure, the course of which was favourable with treatment by haemodialysis. Renal biopsy revealed lesions of acute tubulonephritis with a slight interstitial reaction but without immune deposits. The demonstration in the serum and on the red cells of the patient of anti-catechine antibodies confirmed the immunoallergic nature of the haemolysis. The existence of crossed allergy with another venotropic agent, leucocyanide, led to suspicion of the localisation of the antigenic site on the 3-4 dihydroxyphenyl portion of the catechine molecule.

Acute Kidney Injury↗