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Biomedical subjects

S Mayer

Publications and source records attributed to S Mayer.

At least 181 records · Page 10Linked to original sources
PubMed1979

[Persisting deficiency of cell mediated immunity in Hodgkin's disease in complete remission (author's transl)].

There is increasing evidence in the literature for persistent deficiency in cell-mediated immunity (CMI) in Hodgkin's diseases during apparent remissions after discontinuation of the treatment. Patients were followed for 6 months to 2 years after all treatments were stopped. There was a high percentage (41.6) of subjects with skin anergy to seven recall antigens, a highly significant (p less than 0,0001) decrease, as compared with controls, in total and active E rosettes independently from the number of lymphocytes, and a highly significant diminution of T-lymphocyte in vitro reactivity to various doses of phyto haemagglutinine (PHA). There was no difference between the patients tested between 6 months and 1 year and those tested more than 2 years after treatment. No correlation between skin tests and active rosettes was found in this series. Finally, the CMI deficiency is some what different in patients on remission and in untreated patients.

Female↗
PubMed1979

[Materno-foetal transfer of anti-HLA antibodies. Study by using LDA test (author's transl)].

The LDA test was used to study the materno-foetal transfer of anti-HLA antibodies. The results were compared with those obtained earlier by the complement dependent lymphocytotoxicity test (CdL). Although more sensitive than CdL, the LDA test did not demonstrate more maternal antibodies in cord blood when these antibodies corresponded to the child's paternal antigens. Nevertheless LDA demonstrated antibodies did not always behave similarly to those seen by CdL.

Antibody-Dependent Cell Cytotoxicity↗
PubMed1979

[Extraction and purification of the chief glycoprotein of the erythrocyte membrane].

The major glycoprotein of the human erythrocyte membrane has been released from ghosts, by the non-ionic detergent Tween 20 at pH 8,5 and at low ionic strength and further purified by successive passages through columns of DEAE Sephadex at pH 6,8 and CM Sephadex at pH 5 or by hydroxyapatite chromatography at pH 6,8. The purified glycoprotein thus obtained represents about 1 % of the membrane proteins, and shows two major bands upon polyacrylamide gel electrophoresis. These bands designed as PAS 1 and PAS 2 are the dimer and the monomer of the glycoprotein. Several other minor bands can also appear on SDS gels, according to experimental conditions of solubilization and purification and are probably oligomers of PAS 1 and PAS 2. This glycoprotein possess inhibitory activity against various phytohemagglutinins.

Carbohydrates↗
PubMed1979

Lack of linkage between acute intermittent porphyria and the A and B loci of the HLA system.

Forty-six members of a family known to have Porphyria were studied. As the disease is often latent clinically, erythrocyte uroporphyrinogen I synthetase activity was determined to classify the subjects as being healthy or carriers. HLA--A, B, C, Bf, GLO antigens were determined. No linkage between acute intermittent Porphyria and the HLA system was noted in this family.

Acute Disease↗
PubMed1979

ATP sulfurylase from Penicillium chrysogenum: is the internal level of the enzyme sufficient to account for the rate of sulfate utilization?

The in vivo rate of sulfate activation in Penicillium chrysogenum (wild-type strain ATCC 24791) was determined to be 0.19 +/- 0.09 mumol g(-1) (dry weight) min(-1) by the following methods. (i) The maximum growth of the organism in synthetic medium was a linear function of the initial Na(2)SO(4) concentration between 0 and 8 x 10(-4) Na(2)SO(4). The growth yield was 1.64 x 10(-2) g (dry weight) of mycelium per mumol of added sulfate, corresponding to a minimum sulfur requirement of 61 mumol/g (dry weight). Under these conditions (limiting sulfate) the minimum doubling time of P. chrysogenum in submerged culture was about 3.8 h, corresponding to a maximum exponential growth rate constant of 3.0 x 10(-3) min(-1). If all the sulfur in this mycelium passed through adenosine-5'-phosphosulfate, the rate of sulfate activation in vivo must have been 0.183 mumol min(-1) g(-1) (dry weight). (ii) In the presence of excess (35)SO(4) (2-), the total organic (35)S produced varied with the mycelial growth rate. However, until the culture approached maximum density, the product of [(growth rate constant) x (organic (35)S content)] was nearly constant at 0.24 to 0.28 mumol min(-1) g(-1) (dry weight). (iii) A sulfur-starved mycelium pulsed with 10(-4) M (35)SO(4) (2-) produced organic (35)S at a rate of about 0.10 mumol min(-1) g(-1) (dry weight) under conditions where the internal concentrations of ATP and sulfate would permit ATP sulfurylase to operate at about 70% of its V(max). Cell-free extracts of P. chrysogenum growing rapidly on excess sulfate contained 0.22 U of ATP sulfurylase per g (dry weight). Thus, in spite of the relatively low specific activity of homogeneous ATP sulfurylase (0.13 U/mg of protein, corresponding to an active site turnover of 7.15 min(-1)), the mycelial content of the enzyme was sufficient to account for the observed growth rate of the organism on inorganic sulfate as the sole sulfur source.

Biological Transport, Active↗
PubMed1979

[Clinical, pathologica and genetic analysis of 53 cases of broncho-pulmonary cancer, still surviving after 5 years (author's transl)].

The authors take up again the clinical, pathological and genetic analysis of 53 bronchial cancers with a survival exceeding 5 years. The operation samples were reexamined; a H.L.A. grouping was done in every cases. On the whole, it concerned patients under 60 in good general condition; the extension of their lesions only required a limited exeresis (lobectomy). The epidermoid form predominates, the lymph node invasion is rare. Seventy four per cent of the patients carry at least one of the following antigens: W 19, A 10, B 5, BW 35. But the study did not prove the existence of a genetic factor conditioning the survival.

Bronchial Neoplasms↗
PubMed1978

[Hereditary antithrombin III deficiency causing recurrent thrombo-embolic problems (author's transl)].

A marked deficiency in antithrombin III (AT III) was demonstrated in a 39-year-old man suffering from recurrent thrombo-embolic problems. The patient's father had died following a thrombo-embolic disorder. A certain number of members of the family also showed evidence of a marked decrease in AT III levels. Although it was not possible to study the patient's parents, it would seem reasonable to conclude that the diagnosis was one of hereditary deficiency in AT III. The various aspects of this disorder discovered by Egeberg are reviewed: early onset, in several members of the same family, or recurrent thrombo-embolic problems, accompanied by a decrease in functional activity of one of the principal inhibitors of thrombin (AT III), with autosomal dominant transmission and treatment based upon anti-vitamin K agents.

Adult↗
PubMed1978

[Genetic linkage of HLA-Bf. Study of 19 informative families].

Since the discovery of the linkage between HLA and Bf by Allen in 1974 several reports have shown a very close linkage between Bf and HLA-B. We have studied 19 families with 81 offsprings for the linkage between HLA (A,B) and Bf. The total "lod scores" in our material for the linkage between HLA-B and Bf is 17,167 at theta = 0.00. No recombination was observed between HLA-B and Bf. One recombination out of 79 informative meiotic divisions was observed between HLA-A and Bf. This result would mean that the Bf locus is about 1.3% recombination fraction far from the HLA-A locus. Our estimation is in good agreement with the results of other authors. However the estimation of recombination fractions is only an arbitrary mean to map genetic loci on chromosomal regions and family studies of cases with intra-HLA cross-overs are of more interest. All available data from the litterature are in favour to a very close linkage between Bf and HLA-B and to a situation of the Bf locus between HLA-B and HLA-D. However some conflicting data on Bf gene mapping have been published. More precise informations may be obtained as soon as a more exact structure of the HLA region, in particular of the HLA-D region, will be known.

Adult↗
PubMed1978

Influence of the major histocompatibility complex in the pig (SLA) on serum haemolytic complement levels.

Sera from fourty-six non-congenic adult pigs from one inter-related herd were tested for their haemolytic serum complement levels. A comparison of these data with the major histocompatibility complex (SLA) genotypes of these animals resulted in the demonstration of highly significant differences in lytic activity between sera obtained from animals of two distinct SLA haplotypes. These data showed a high correlation between the SLA complex and the level of haemolytic activity.

Animals↗
PubMed1978

[Myelosclerosis : pseudo-tumors forms (author's transl)].

Signs of pseudo-tumor growth may be seen in myelosclerosis. Eight personal cases and a review of the literature are discussed in this article. The observations here reported cover pseudo-tumors occurring in ganglia, liver, suprarenals (3), abdomen and pancreas. They are classified as sclerotic haemopoietic tumors. This category has particular characteristics when compared to extra-medullary haemopoiesis, extra-medullary haemopoietic growths, and a fourth category, sarcoma-type malignant tumors in myelosclerosis. The identity of these last three entities is widely discussed in the literature. The main histological and cytological characteristics for pseudo-tumor diagnosis in myelosclerosis are reported here.

Abdominal Neoplasms↗
PubMed1978

[Materno-foetal transfer of anti-HLA antibodies. Study by using LDA test (author's transl)].

The LDA test was used to study the materno-foetal transfer of anti-HLA antibodies. The results were compared with those obtained earlier by the complement dependent lymphocytoxicity test (CdL). Although more sensitive than CdL, the LDA test did not demonstrate more maternal antibodies in cord blood when these antibodies corresponded to the child's paternal antigens. Nevertheless LDA demonstrated antibodies did not always behave similarly to those seen by CdL.

Cytotoxicity Tests, Immunologic↗