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Biomedical subjects

S Mayer

Publications and source records attributed to S Mayer.

At least 199 records · Page 11Linked to original sources
PubMed1978

[Neo-natal neutropenia induced by anti-NA 2 allo-immunization. Serological and clinical study of 2 cases in a family].

A severe neutropenia in a 2 day old newborn drew attention to anti-HLA and NA 2 antigranulocytic antibodies in the maternal serum. Close supervision from birth of a younger sibling demonstrated a neutropenia on the 5th day of life. Serological investigation showed the anti-NA 2 antibody to be responsible in both cases. A good result with total blood replacement of leucocyte-free blood in the second case would advocate this treatment in cases of severe immunological neutropenia.

Agranulocytosis↗
PubMed1977

Bf polymorphism: another variant (S0.8).

A "new" variant band in the Bf system has been found in the serum of three individuals belonging to a tribe of Brazilian Indians (Karaja--Bananal--Goias) and in the serum of a Caucasian individual from the area of Strasbourg. It is highly probable that the band represents another allele at the Bf locus BfS0.8.

Alleles↗
PubMed1977

Absorption tests on cold lymphocytotoxins: preliminary report.

Tests were carried out to absorb cold lymphocytotoxic antibodies on different types of cells. These included lymphocytes and neuraminidase-treated lymphocytes from healthy donors, thymocytes from children undergoing open heart surgery, fetal thymocytes, human brain and cultured lymphocytes. The results showed these antibodies to be absorbed on some types of cells and eluted from others. The best absorption was obtained with fetal thymocytes and brain tissue.

Absorption↗
PubMed1977

Hereditary diffuse articular chondrocalcinosis. Dominant manifestation without close linkage with the HLA system in a large pedigree.

Thirty-nine members of one family, covering three generations, were HLA-typed. Twenty-five suffered from primary diffuse articular chondrocalcinosis, and all had the same dominantly transmitted autosomally controlled disease. This was characterized by acute articular attacks, which always started before the age of 35, and radiologically by typical cartilaginous and fibrocartilaginous deposits associated with para-articular calcifications. The lesions were both peripherally and axially generalized. None of the 28 HLA antigens tested seemed related to the disease, nor did the disease segregate with an HLA haplotype.

Adult↗
PubMed1977

[Autologous and allogenic human rosettes].

A proportion of human peripheral blood T lymphocytes have the property to form spontaneous rosettes in vitro with autologous and allogeneic red blood cells. In our experience the percentage of allo-rosettes is higher than the percentage of auto-rosettes. Red blood cells of the Bombay type are capable of binding to allogeneic lymphocytes. However a low percentage of auto-rosettes was found in the Bombay donor.

Erythrocytes↗
PubMed1977

[Study of the antibody-dependent lymphocytotoxicity test as a function of the nature of the antibodies].

It is well known that IgM antibodies are inactive for the LDA test. Moreover, this work showed 7 S IgM to be just as inactive as 19 S IgM. With HLA antibodies, usually IgG, this work showed that the LDA test was not inhibited by a temperature of + 15 instead of + 37 degrees C. With cold lymphocytotoxic antibodies 19 S and 7 S IgM the LDA test was negative even at + 15 degrees C (optimum temperature for these complement dependant lymphocytotoxic antibodies) with or without prolonged incubation. Under these same conditions, a negative result was obtained using auto-lymphocytes as a target. Finally, our results confirmed that IgM antibodies with anti-HLA activity could not act as mediators even for targets with corresponding HLA activity.

Antilymphocyte Serum↗
PubMed1977

Human autologous and allogeneic rosettes with erythrocytes of the Bombay type.

Human red blood cells of the Bombay type which lack ABH group substances can bind to allogeneic lymphocytes just as well as erythrocytes of any other type. A much lower percentage of auto-rosettes between erythrocytes and lymphocytes from the Bombay donor was observed, a result which may be due at least partially to some T lymphocyte defect in the Bombay donor.

Blood Group Antigens↗
PubMed1977

Normal active rosette-forming-cells in untreated patients with Hodgkin's disease.

The percentage of E-rosettes and active E-rosettes was determined in untreated patients with Hodgkin's disease. All patients had numbers of peripheral blood lymphocytes within the normal range (1,200-5,000 lymphocytes/cu mm). The mean percentage of E-rosettes was significantly lower in the patients (55 +/- 15.7) as compared to normal controls (63 +/- 6.7). No difference in the percentage of active E-rosettes was found (36.6 +/- 8.6 in controls versus 40.3 +/- 10.8 in patients).

Hodgkin Disease↗
PubMed1976

Bf polymorphism: study of a new variant (F0.55).

A variant band in the Bf polymorphism has been found in the serum of a healthy women, her mother, her sister, and two brothers. By direct comparison the band was found to migrate faster than F but slower than F1. It is highly probable that the band represents a new allele at the Bf locus, Bf 0.55. The new allele was transmitted in this family together with the HLA haplotype A11, B27.

Alleles↗
PubMed1976

[Cerebromeningeal hemorrhages and their sequelae in congenital deficiencies of plasma hemostasis factors. Apropos of a case of Stuart factor deficiency with early cerebromengeal hemorrhage leading to hydrocephalus with considerable psychomotor retardation].

We have taken an interest in cerebro meningeal haemorrhages in congenital plasmatic coagulation Factor deficiency with out obvious traumatic origin. We have observed such accidents in a new born child with congenital Stuart factor deficiency and in four cases of haemophilia A. It seems from our experience and from the literature that such haemorragic accidents are not particularly frequent in congenital coagulation deficiency and contribute only for a few to creation of a psychomotor inadapted population.

Cerebral Hemorrhage↗