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Biomedical subjects

S Maeda

Publications and source records attributed to S Maeda.

At least 883 records · Page 49Linked to original sources
PubMed1985

[A case of leiomyosarcoma of the inferior vena cava].

A case of primary leiomyosarcoma of the inferior vena cava was reported. The patient, a 74-year-old man, consulted our hospital with complaints of back pain and abdominal mass in right flank. Probe laparotomy revealed a tumor situated in the retroperitoneum and multiple metastatic nodules in the liver. Biopsy was performed and diagnosed as leiomyosarcoma. He was intensively treated with antineoplastic chemotherapy, but his condition gradually aggravated. He died 4 months after admission. The autopsy revealed a right retroperitoneal mass (17 X 12 X 18 cm in size, 1,340 g in weight) that showed a yellowish appearance. There was also a thumb-tip sized tumor with a stalk in the lumen of inferior vena cava. Both tumors grew in continuity with each other through the wall of inferior vena cava. The tumors were diagnosed as leiomyosarcoma, which derived from inferior vena cava.

Aged↗
PubMed1985

[Ileal artery aneurysm: a case report and review of literature].

In a 70-year-old Japanese male who had a history of a radical operation of ruptured descending thoracic aortic aneurysm, the ileal artery aneurysm developed asymptomatically during postoperative follow up period. The aneurysm was about 10 by 4.5 by 4 cm in size and atherosclerosis microscopically. This case seemed to be the 20th case of superior mesenteric artery aneurysm and the 4th case of ileal artery aneurysm reported in Japan. Furthermore, this may be the first report of ileal artery aneurysm associated with thoracic aortic aneurysm in Japanese and English literature.

Aged↗
PubMed1985

[A review of thirteen carotid surgeries in ten patients].

During the period of 3 years and 9 months (from September 1980 to May 1984), 44 patients with arteriosclerosis of the carotid arteries were seen at our hospital. In 10 of them, arterial reconstructive surgery was performed. There were 7 men and 3 women. Ages ranged from 50 to 75 years (mean, 61.9 years). They had a total of 13 lesions in the carotid arteries, which were composed of one complete obstruction, 10 stenoses, one aneurysm, and one tortuosity. These lesions were treated by either thromboendarterectomy (TEA), TEA along with vein patch, vein patch, or aneurysmorrhaphy. Three of these 10 patients were subjected to the second operation because of remaining disease or recurrence of symptoms.

Aged↗
PubMed1984

Cloning and sequence analysis of cDNA for human prealbumin.

A cDNA coding for human prealbumin has been cloned from a cDNA library prepared from human liver. The DNA sequence codes for a polypeptide which consists of 147 amino acids including a whole human prealbumin sequence and a putative signal sequence. The elucidation of this prealbumin cDNA sequence is expected to facilitate a prenatal diagnosis of familial amyloidotic polyneuropathy.

Amino Acid Sequence↗
PubMed1984

Changes in asparagine-linked sugar chains of human promyelocytic leukemic cells (HL-60) during monocytoid differentiation and myeloid differentiation. Decrease of high-molecular-weight oligosaccharides in acidic fraction.

Asialo-oligosaccharides obtained by sialidase digestion of asparagine-linked acidic sugar chains of promyelocytic leukemic cells (HL-60) differed in size distribution from those of cells induced to undergo myeloid or monocytoid differentiation. High-molecular-weight oligosaccharides which are predominant in HL-60 cells, decreased slightly during myeloid differentiation and markedly during monocytoid differentiation with concomitant increase of biantennary oligosaccharides. Structural analyses revealed that the induced monocytoid cells contain a series of complex-type oligosaccharides with bi-, tri-, and tetraantennary structures and high-molecular-weight oligosaccharides with N-acetyllactosamine repeating units, which show diversity in the presence or absence of the fucose residue linked to the reducing terminal N-acetylglucosamine, of the bisecting N-acetylglucosamine residue, and of the X-antigenic determinant in their outer chain moieties. Methylation analysis of each class of oligosaccharides of HL-60 cells and of their differentiated counterparts revealed the presence of similar heterogeneity in their structures, indicating that the difference is only quantitative. The results show that the shifts in size of the oligosaccharides found in the differentiated cells are derived from changes in outer chain formation and elongation of N-acetyllactosamine repeating units, and thus suggests that the decreased expression of N-acetylglucosaminyltransferases may be involved especially in the monocytoid differentiation program.

Asparagine↗
PubMed1984

Changes in asparagine-linked sugar chains of human promyelocytic leukemic cells (HL-60) during monocytoid differentiation and myeloid differentiation. Appearance of high mannose-type oligosaccharides in neutral fraction.

Structural changes in the asparagine-linked sugar chains of plasma membrane glycoproteins during myeloid and monocytoid differentiation were investigated by the use of an in vitro differentiation system for human promyelocytic leukemic cells (HL-60), which can be induced to more mature myeloid cells by exposure to dimethyl sulfoxide and to macrophage-like cells by a phorbol ester. The asparagine-linked sugar chains released from their plasma membranes by hydrazinolysis were separated into a neutral fraction and an acidic fraction composed of over ten components. The content of neutral oligosaccharides, which accounted for 8% of the total asparagine-linked sugar chains in HL-60 cells, increased slightly to 13% in dimethyl sulfoxide-induced cells and markedly to 33% in phorbol ester-induced cells. Structural analyses revealed that the neutral oligosaccharides of HL-60 cells are all of the complex type with a variety of Gal beta 1----4GlcNAc beta 1----units in their outer chain moieties and the following core structure: (sequence; see text) After myeloid and monocytoid differentiation, the total amount of neutral complex-type sugar chains did not change significantly, but newly found high mannose-type sugar chains contributed up to 3% and 24% of the total sugar chains, respectively.

Asparagine↗
PubMed1984

Detection of human T-cell leukemia virus antibodies in a Japanese T-cell leukemia patient with hypercalcemia.

A T-cell (KH-2) from a Japanese T-cell leukemia patient with hypercalcemia has been characterized and shown to be similar in its properties to Human T-cell leukemia virus (HTLV)-positive T-cell lines from T-cell leukemia patients from different parts of the world. The HTLV isolated from the Japanese T-cell leukemia patient with hypercalcemia belongs to the HTLV family and has properties similar to HTLV from T-cell leukemia patients from the United States, Israel, and the Caribbean.

Antibodies, Viral↗
PubMed1984

Alterations in erythrocyte membrane lipids in abetalipoproteinemia: phospholipid and fatty acyl composition.

Scanning electron microscopic observation revealed that there were wide variations including typical acanthocytes in morphology of erythrocytes from a patient with abetalipoproteinemia. The erythrocyte membrane phospholipids and cholesterol contents from a patient was higher by 25% compared to an age-matched control subject. Analysis of phospholipid composition of red blood cells showed an increase of sphingomyelin (25.1----30.1%) with a concomitant decrease of lecithin (27.5----21.0%). Thus, the sphingomyelin/lecithin ratio was increased dramatically (0.91----1.43). As for fatty acyl chain composition of main phospholipids, an increased percentage of palmitic acid and docosahexaenoic acid and a decreased proportion of arachidonic acid and lignoceric acid were observed for sphingomyelin. There was an increment of palmitic acid which was accompanied with a decrease of linoleic acid in lecithin. On the other hand, no significant difference was shown in the fatty acid composition of phosphatidylethanolamine and phosphatidylserine plus phosphatidylinositol between a patient and control.

Abetalipoproteinemia↗
PubMed1984

HLA-A and B antigens in patients with Peyronie disease.

Using microdroplet lymphocyte cytotoxicity test, as a method of HLA typing, 9 patients with Peyronie disease were studied from a viewpoint of relationship between this disease and HLA-A and B antigens. The frequencies of each antigen in the patients were compared with those of healthy controls. No significant difference of distribution in HLA antigens was observed between the patients and the control group.

Adult↗
PubMed1984

Effect of tumor promoters on human T cell leukemia/lymphoma virus (HTLV)-structural protein induction in adult T-cell leukemia cells.

We assayed the capacity of tumor promoters to induce human T-cell leukemia/lymphoma virus (HTLV) structural proteins p19 and p24 from the HTLV genome-carrying adult T-cell leukemia (ATL) cell lines, MT-1 and KH-2Lo, and fresh ATL cells. Among the tested substances, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 12-hexadecanoyl-phorbol-13-acetate (HPA) and teleocidin induced HTLV structural protein p19 and p24. This suggests that certain environmental substances, especially those known to be tumor promoters, may activate the HTLV-gene in ATL cells.

Adult↗
PubMed1984

Comparison of protein composition between schistosomula of Schistosoma japonicum and S. mansoni.

SDS-PAGE analysis revealed that the protein composition of mechanically transformed schistosomula (ms) of a Japanese strain of Schistosoma japonicum was essentially similar to that of a Philippine strain of S. japonicum. However, the protein components of S. mansoni ms were remarkably different from those of S. japonicum. Specific proteins of Mr 60-65 and 30 kDa were found in ms of S. japonicum and S. mansoni, respectively. In skin-penetrated schistosomula (ss) of the two species, a common protein of 67 kDa was detected. Using two-dimensional electrophoresis, strain-specific polypeptides (9 in a Japanese and 11 in a Philippine strain) were identified in ms of S. japonicum. Mechanically transformed and skin-penetrated schistosomula of S. japonicum (Japanese) had, respectively, 7 and 10 specific proteins. Four and 1 specific polypeptides were also detected in two-dimensional profiles of ms and ss of S. mansoni, respectively.

Animals↗
PubMed1984

Giant lamellar bodies in alveolar type II cells of rats exposed to a low concentration of ozone.

The effect of a low concentration of ozone on pulmonary surfactant release was examined by the ultrastructural morphometry of lamellar bodies in alveolar type II cells. Rats were exposed to approximately 0.3 ppm of ozone for 3 h daily for 16 consecutive days. The volume density of lamellar bodies, relative to the cell, increased significantly following ozone exposure. After 11 days giant lamellar bodies were found in ozone-exposed rats. These findings suggest that ozone exposure causes the impairment of pulmonary surfactant release.

Animals↗
PubMed1984

Relation between selective alveolo-bronchograms and pulmonary function tests in patients with chronic obstructive pulmonary disease.

We studied the relation between selective alveolo-bronchograms (SAB) and pulmonary function tests in patients with chronic obstructive pulmonary disease (COPD) other than asthma. The SAB were obtained by the technique reported by Nakamura and coworkers (Tohoku J Exp Med 1969; 99:207). First, the relation between SAB and morphologic findings was examined in 14 autopsy lungs in order to confirm the morphologic bases of the shadows. The ring shadows that appeared in the SAB were histologically identified as alveolar ducts in normal lungs and as destroyed parenchymal air spaces in emphysematous lungs. There was a significant correlation between the mean diameter of ring shadow (DR) and the degree of morphologic emphysema (p less than 0.001). This correlation indicated a significant degree of emphysema when the DR exceeded 900 micron. The irregularity index of the airway in SAB also showed a significant correlation to the grade of pathologic abnormalities in the airways (p less than 0.01). Second, SAB were obtained in 64 patients with COPD in whom pulmonary function tests were performed. In these patients, the DR correlated significantly with most of the pulmonary function tests. This correlation was especially high with transfer factor (DLCO/VA). These 64 patients were divided into 2 groups on the basis of the DR: In Group A, DR was more than 900 micron, whereas in Group B, it was less than 900 micron. In Group A, the DR also showed a significant correlation with DLCO/VA and with diffusing capacity (DLCO); in Group B, significant correlations were found in the irregularity index, especially with regard to pulmonary resistance and the ratio of forced expiratory volume in one second to vital capacity.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗