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Biomedical subjects

S Koike

Publications and source records attributed to S Koike.

At least 271 records · Page 15Linked to original sources
PubMed1982

Enhanced radiation lethality in partially synchronized solid mouse tumors.

We studied the combined effects of local irradiation on in vivo partially synchronized solid mouse tumors. Syngeneic fibrosarcoma cells were transplanted s.c. into the thighs of C3H/He mice. When the tumors grew to 179 cu mm in volume, 1-beta-D-arabinofuranosylcytosine (ara-C) was repeatedly injected i.p. followed by a single injection of vinblastine sulfate at 5 hr after the end of the ara-C treatment. The mitotic indexes increased from 4% in control to 22 to 23% at 5 hr after the ara-C treatment, and the level continued for another 5 hr. Further treatment with vinblastine sulfate after the ara-C injections resulted in more effective accumulation of mitotic cells, i.e., 30% at the sixth hr. The tumor was locally irradiated with a single dose of 3000 rads of gamma-rays at the maximum level of mitotic index. The results indicated a synergistic inhibition of tumor growth and an 84% prolongation of the 50% survival day beyond that of the nontreated control mice.

Animals↗
PubMed1981

Fat tolerance test in pregnancy: Intralipid loading test.

Hyperlipemia occurs during pregnancy. The present study deals with lipid metabolism in the female by comparing the response of the pregnant with that of non-pregnant females to a lipid loading test with 10% Intralipid given intravenously. The results were: (i) Exogenous and endogenous triglycerides (TG) were significantly higher inthe pregnant group. (ii) The K2 value was significantly lower in the pregnant group. (iii) The level of FFA in the non-pregnant group rose rapidly 5 min after Intralipid load. In contrast, the pregnant group showed a gradual rise which reached a maximum one hr after administration of Intralipid. The delay of the lipid metabolism during pregnancy might be one of the reason of hyperlipemia.

Adult↗