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Biomedical subjects

S Koike

Publications and source records attributed to S Koike.

At least 289 records · Page 16Linked to original sources
PubMed1980

Clinicopathological study of coxsackie B viral myocarditis.

Autopsy cases of myocarditis caused by Coxsackie viruses in two infants, aged 5 years and 10 months and 12 years, and two adults, aged 24 years and 45 years, were presented. Of the four cases, three revealed a rise in serum neutralization titer to Cox B,4 virus and one to both Cox B2 and Cox B4 viruses. Compared with the adult cases, the 2 infant cases showed less inflammatory response with relatively prominent hypertrophy in the heart. Both of the adult cases revealed intensive inflammatory reaction. Extensive inflammatory cell infiltration remained in one of the adult cases though the case survived about 4 years after manifestation of the infection, suggesting possible involvement of immunological factors.

Adult↗
PubMed1980

Waveform and spectral analysis of crackles.

Crackles were recorded from six patients, four with tuberculosis and two with chronic bronchitis. It was observed by waveform and spectral analysis that most of the frequency components of a crackle were limited within a range of 0.1 to 1 kHz. Characteristically, waveforms of crackles were separable into two segments, initial "starting segments" and subsequent "decay segments." It is suggested that the former represents a shock wave caused by an abrupt opening of the airway and that the latter is a damped sinusoid caused by this shock wave exciting a resonator in the lung. It is speculated that the starting segment is determined by the pressure ratio at the site of the airway opening, and the decay segment by the resonant frequency and the quality factor of the resonator. Because transmission of a crackle is highly directional the waveforms recorded on the chest wall are modified by the positional relationship between the sound source and the microphone.

Bronchitis↗
PubMed1980

Comparison of the effects of neutron and/or photon irradiation on spontaneous squamous-cell carcinoma in mice.

The effect of 30MeV D+ leads to Be NIRS cyclotron neutrons on a spontaneous NR-S1 squamous-cell carcinoma was studied. The TD50 (number of tumor cells required for transplantation in half the sites) and tumor growth delay time (TGD) were determined. The RBE of 200-kVp x rays at the 10% survival level was 1.9 for aerobic cells and 2.0 for hypoxic cells; the OER at the same level was congruent to 1.7. Tumor cells irradiated with neutrons were unable to repair potentially lethal damage, in contrast to x-irradiated tumor cells. The RBE of 50-MeV D+ leads to Be neutrons was inversely related to deuteron energy for hypoxic cells. The relationship between TGD and peak skin indicated no benefit from mixed beams or 5 neutron doses.

Animals↗
PubMed1979

Secondary malignant neoplasms following radiotherapy of a mouse mammary carcinoma.

Long-term observations were made for the development of secondary neoplasms following radiotherapy of animal tumors. Experimental tumors were 3rd generation isotransplants of a mammary carcinoma which arose spontaneously in a C3Hf/He mouse. A single dose of TCD20-TCD98 was followed by weekly observations. Most recurrences were observed in the first 150 days, while only a few were seen in the subsequent 150 days. Secondary neoplasms developed frequently following this period, i.e., 41 out of 67 animals surviving more than 300 days developed secondary neoplasms. They were osteogenic and soft tissue sarcomas, and half the new tumors were found within 490 days after radiotherapy. The results obtained were compared with literature reports of secondary neoplasms following postoperative radiotherapy for carcinoma of the breast and treatment of retinoblastomas. Most of these secondary human neoplasms were nonepithelial sarcomas as in the present study. Secondary carcinomas have been reported following radiotherapy of carcinoma in other locations, i.e., the cervix or head and neck; however, only a limited number of studies have been reported.

Animals↗
PubMed1979

Kawasaki disease: effect of treatment on coronary artery involvement.

Ninety-two patients with Kawasaki disease were treated with five different types of drug therapy: a steroid preparation (prednisolone), aspirin, an antibiotic, a combination of steroid plus aspirin, and a combination of steroid plus warfarin. One or two months after the onset of the disease, coronary angiography demonstrated coronary aneurysms in 20% of cases treated with an antibiotic alone, 64.7% of cases in the steroid-treated group, and 11% of those in the aspirin-treated group. These findings suggest that the steroid might act adversely to cause a progression of coronary lesions of the disease. The aspirin-treated group did not have a significantly lower incidence of coronary lesions compared with the group treated with an antibiotic alone. But in view of the fact that the direct cause of sudden death of the disease is thrombotic occlusion of a coronary artery, aspirin might act as the effective means for prevention of sudden death due to Kawasaki disease.

Aspirin↗