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Biomedical subjects

S K Gupta

Publications and source records attributed to S K Gupta.

At least 811 records · Page 45Linked to original sources
PubMed1981

Primary tuberculous enterocolitis. Report of three cases and review of the literature.

Three patients had primary enteric tuberculosis. Therapy included antituberculous chemotherapy and resection of the involved segment of bowel with primary anastomosis in each case. The symptomatology, roentgenographic findings, histopathology, and treatment of enteric tuberculosis are reviewed. The surgeon must be aware of the fact that primary enteric tuberculosis continues to exist in the United States. Though no pathognomonic symptoms or syndrome occur in enteric tuberculosis, this disease should be included in the differential diagnosis of patients with vague abdominal complaints, weight loss, and anorexia.

Adult↗
PubMed1981

Spontaneous resolution of popliteal artery thrombosis.

Spontaneous resolution of thrombosis of the systemic arteries is a rarely documented phenomenon. Two patients are described in whom thrombus within the popliteal artery was noted to lyse spontaneously. This resulted in a decrease in ischemic symptoms and was documented by angiography. The spontaneous improvement that occurs in some patients with atherosclerotic femoropopliteal disease may be due to this mechanism as well as to increased flow via collateral vessels.

Aged↗
PubMed1981

Carcinoma in choledochal cyst.

Two cases of choledochal cyst associated with adenocarcinoma are documented. The classical triad of jaundice, abdominal mass, and pain is not distinctive enough to make the preoperative diagnosis of a choledochal cyst and its associated malignancy. Operative cholangiogram is a very important investigation, as by the presence of a filling defect in the cyst it can suggest malignancy. In our cases the diagnosis of malignancy was made at operation, which was confirmed by histopathological examination. Internal drainage procedures in combination with chemotherapy by 5 FU rendered both the cases asymptomatic.

Adenocarcinoma↗
PubMed1981

Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains.

We report further progress in exploiting our earlier discovery that the anticoccidial activity of 6-azauracil increases markedly when appropriately substituted benzyl or phenyl groups are attached at N-1. With guidance from previous structure-activity relationships and a multiple linear regression analysis, 6-azauracils containing phenyl sulfone or phenyl sulfide side chains were prepared. These prevented a broad spectrum of coccidial infections in chickens at minimum inhibitory concentrations by weight in feed as low as 0.25 ppm, a 4000-fold increase in potency over 6-azauracil, and had shorter plasma half-lives than earlier potent analogues. Sulfides were more potent than sulfones, although they were oxidized rapidly to sulfones in vivo.

Animals↗
PubMed1981

Immunochemical measurement of serum prostatic acid phosphatase (PAP). Clinical evaluation of radioimmunoassay and counter immunoelectrophoresis.

Two radioimmunoassay procedures (RIA-1 and RIA-2) were evaluated for the quantitation of prostatic acid phosphatase in serum and compared with the enzymatic method and counter immunoelectrophoresis method for their specificity and sensitivity. Sera from 168 patients were analyzed and these included: normals, 27; untreated prostatic cancer patients Stage A, 2; Stage C, 3; Stage D, 17; cancer of prostate treated with different modalities, 42; sarcoma of prostate, 1; prostatitis, 3; nonprostatic carcinoma, 17; and benign prostatic hyperplasia (BPH), 56. RIA-1 procedure appeared more sensitive (82% sensitivity) and specific (94.5% specificity) than the RIA-2 procedure (68% sensitivity and 91.8% specificity), but the differences were not statistically significant. The enzymatic method was found to be least sensitive (63.6% sensitivity) but also the most specific (100% specificity). Only 69 of the specimens were analyzed by counter immunoelectrophoresis, which showed sensitivity of 87% and specificity of 51.4%. False positives were observed more often in patients with nonprostatic cancer and BPH. The variations in diagnostic specificity of immunologic assays suggest the need of characterization of each antibody specificity.

Acid Phosphatase↗
PubMed1981

Progress in limb salvage by reconstructive arterial surgery combined with new or improved adjunctive procedures.

In the past nine years, 1196 patients whose lower extremity was threatened because of infrainguinal arteriosclerosis have been treated at Montefiore Hospital. In the last six years, limb salvage was attempted in 679 or 90% of 755 patients. Femoropopliteal (318), small vessel (204) and axillopopliteal (29) bypasses were used along with transluminal angioplasty (128) and aggressive local operations to obtain a healed foot. Immediate (one month) limb salvage was achieved in 583 or 86% of the 679 patients in whom revascularization was possible. The 30-day mortality rate was 3%. The cumulative life table (LT) survival rate of all the patients undergoing reconstructive arterial operations was 48% at five years. The cumulative LT limb salvage rate after all reconstructive arterial operations was 66% at five years. The cumulative LT patency rate of femoropopliteal bypasses was not influenced by angiographic outflow characteristics of the popliteal artery but was increased 15% by appropriate reoperations to 67% at five years. Cumulative LT patency and limb salvage rates of small vessel and axillopopliteal bypasses were more than 50% at two years. Of patients undergoing arterial reconstruction, 88% of those who died within five years did so without losing their limbs. Of all the patients in whom limb salvage was attempted, 68% lived more than one year with a viable, useable extremity, and 54% lived over two years with an intact limb. We believe this aggressive approach to limb salvage is justified, and can be undertaken with a low cost in mortality, knee loss and morbidity.

Aged↗
PubMed1981

Aspiration cytology of lymph nodes in leprosy.

Lymph node aspiration cytology smear patterns were analyzed in 60 cases of leprosy. A Type I smear pattern was found in 51.7%, Type II in 25%, Type III in 16.6%, and Type IV in 6.7% of the cases. Comparing with the histopathological diagnosis, Type I and Type II smears corresponded to LL lesions. Type III smears corresponded to BB lesions toward the lepromatous end of the spectrum, and Type IV smears corresponded to BB lesions toward the tuberculoid end of the spectrum. An increasing degree of lymphocytic cell admixture was noticed from Type I to Type IV smears with a changing appearance from classical foamy histiocytes in Type I and Type II smears to atypical histiocytes in Type III smears and epithelioid histiocytes in Type IV cases. These findings correlated with the better cell-mediated immune reactivity observed in these patients as the disease spectrum crosses from Type I and Type II smears to Type III and Type IV smears. A larger number of cases needs to be studied for definite assessment of these criteria.

Biopsy, Needle↗
PubMed1981

Diktyoma.

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Child, Preschool↗