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Biomedical subjects

S K Gupta

Publications and source records attributed to S K Gupta.

At least 793 records · Page 44Linked to original sources
PubMed1982

The factor which aggregates nematode, yeast and liver phosphoglycerate kinase in tRNA.

1. A factor isolated from the free-living nematode, Turbatrix aceti and from yeast, causes aggregation of phosphoglycerate kinase from nematodes, yeast and rat liver. The rat muscle enzyme is not affected. 2. The aggregation factor is either identical to or very similar to tRNA, Pure tRNA from yeast or Escherichia coli, when mixed with nematode, yeast or rat liver phosphoglycerate kinase causes the enzyme to aggregate to higher mol. wt forms. Both the natural factor and tRNA bring about similar changes in the behavior of nematode phosphoglycerate kinase. 3. The tRNA does not remain bound to the enzyme though it appears to cause a sequential aggregation from monomer to tetramer. 4. No conclusion could be reached as to whether the factor plays a physiological role or if it is simply tRNA fortuitously present during purification of the enzyme.

Animals↗
PubMed1982

Sagittal diameter of the cervical canal in normal Indian adults.

This paper is based on a radiographic study of 300 normal individuals from 18 to 34 years of age comprising 207 males and 93 females. A lateral radiograph of the cervical spine with a focal-film distance of 6 ft was obtained of each subject to measure the sagittal diameter of the cervical spinal canal. The mean sagittal diamter ranged from 21.43 mm at C1 to 16.42 mm at C7 in males and from 20.13 mm at C1 to 15.54 mm C7 in females. This diameter decreased from C1 down to C4 or C5 where there was a gradual but marginal increase to C6. This diameter was smallest at C7. In general the sagittal diameters In females were about 1 mm less than in males at all vertebral levels. The smallest sagittal diamter from C3 to C7 in both sexes was 13 mm. The largest sagittal diameter varied from 20.5 to 28 mm in males and 18.5 to 26 mm in females. The mean sagittal diameter showed some relationship to height in males. No significant difference was observed in relation to weight. The posterior component of the sagittal diameter was smaller in females than in males due to a difference in development of the laminae.

Adolescent↗
PubMed1982

Fallibility of intra-operative gram stain in the diagnosis of vascular infection.

Three cases of arterial-graft infection are presented. In all cases the gram stain obtained at surgery demonstrated white blood cells but no bacteria. Cultures obtained at operation subsequently grew Pseudomonas aeruginosa in two patients and Bacteroides fragilis in one patient. Failure to recognize the fallibility of the gram stain in the diagnosis of vascular infection may result in incorrect management decisions.

Aged↗
PubMed1982

Randomization of autogenous vein and polytetrafluorethylene grafts in femoral-distal reconstruction.

A randomized, prospective, controlled study comparing autogenous saphenous vein and polytetrafluoroethylene (PTFE) grafts in infrainguinal arterial reconstructions has been initiated in three different institutions. A total of 446 operative procedures were divided into six groups, depending on the site of distal bypass insertion into the popliteal or an infrapopliteal artery and on whether the patient received a randomized vein or PTFE graft or an obligatory PTFE graft. The randomized saphenous vein graft patency to infrapopliteal arteries was significantly better (P less than 0.005) at 2 1/2 years than the patency of randomized or obligatory PTFE grafts to the same level. No significant differences between randomized vein grafts and randomized or obligatory PTFE grafts in the femoropopliteal position could be demonstrated up to 2 1/2 years, either above or below the knee. The need for such a study and the limitations of this preliminary report are discussed. The requirement for longer observation of greater numbers of cases is stressed. A current plan for usage of the PTFE graft in the lower extremity is presented.

Adult↗
PubMed1982

The in situ characteristics of mononuclear cell infiltrates in dermal lesions of leprosy.

The in situ nature of mononuclear cell infiltrates in the dermal lesions of 38 untreated leprosy patients was studied by means of conventional surface marker techniques using erythrocytes coated with AET, anti-erythrocyte IgG antibody, hemolysin and complement for the identification of T cells, and cells bearing Fc and C3 receptors, respectively. In general, T cells were the predominant lymphocytes in the leprosy lesions. They were mostly seen to be associated with epithelioid cell granulomas and showed maximal density in tuberculoid leprosy. A graded reduction of T cells was observed in borderline leprosy with a severe reduction/absence in polar lepromatous leprosy. The cells of the mononuclear phagocyte series in the various granulomas of the leprosy spectrum showed the presence of Fc and C3 receptors. Cells bearing a higher density of these receptors had a peripheral localization; whereas cells showing diffuse staining for nonspecific esterase were located more in the central regions of the granulomas. The differences in the individual cells of the phagocytic series appeared to be related to cell maturity; whereas the quantity of T cell infiltration in the lesions showed a correlation with the leprosy spectrum.

Complement C3↗
PubMed1982

Thyroid gland responses to intermale aggression in an inherently aggressive wild rat.

The aim of the present investigation was to ascertain whether intermale aggression (by fighting) affects thyroid gland activity in wild rat. Following intermale aggression for three hours, thyro-follicular epithelial height was significantly decreased and colloidal content in follicular lumen increased only in the subordinate rats whereas the thyroid gland of the dominant rats was not perceptibly changed. Thus, aggression inhibits thyroid gland activity only in the subordinate rats. It is suggested that this effect may be due to psychosomatic rather than physical stress during aggression.

Aggression↗
PubMed1982

Level of amputation after failure of limb salvage procedures.

It has been claimed that the level of amputation is rendered higher by unsuccessful limb salvage bypass procedures. To evaluate this premise, we analyzed 242 major amputations performed for atherosclerotic vascular disease. One hundred and sixty-one amputations were performed as primary operations--50 per cent being below knee and 50 per cent, above knee amputations. Eighty-one amputations followed failure of an arterial revascularization. Twenty-three amputations, 13 below knee and ten above knee, followed late closure of such bypass procedures. Early failure of the bypass in 58 patients resulted in 46 below knee and 12 above knee amputations. After failure of 45 bypasses to arteries distal to the popliteal, 14 of the patients required above knee amputation. Following 28 unsuccessful femoropopliteal bypasses, only two patients needed above knee amputation. Thus, the risk of jeopardizing the knee joint should not be considered a major contraindication to limb salvage procedures, especially if a femoropopliteal bypass is contemplated.

Amputation, Surgical↗
PubMed1982

Enterolithiasis.

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Adult↗