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Biomedical subjects

S K Gupta

Publications and source records attributed to S K Gupta.

At least 829 records · Page 46Linked to original sources
PubMed1981

Superficial femoral and popliteal arteries as inflow sites for distal bypasses.

In a series of limb salvage bypass to the popliteal and infrapopliteal arteries, the superficial femoral and popliteal arteries were used preferentially to provide inflow if these vessels were no more than minimally diseased proximal to the site of bypass origin. Cumulative life-table patency rate at 6 years for popliteal bypasses was 66% for 290 cases originating from the common femoral and 81% for 60 cases originating from the superficial femoral and popliteal arteries (P greater than 0.1). Infrapopliteal bypass patency rate at 5 years was 50% for 129 cases originating from the common femoral artery and 58% for 79 cases originating more distally (P greater than 0.25). When vein grafts alone were considered, patency rates were still not influenced by the site of origin of popliteal and infrapopliteal bypasses. Only 1 of 32 failures of a bypass with a distal origin could have been caused by proximal progression of disease. Because of these findings and multiple advantages that result from using arteries distal to the common femoral for bypass inflow, preferential use of the superficial femoral and popliteal arteries for this purpose is recommended in appropriately selected patients.

Adult↗
PubMed1981

Femoropopliteal bypass to the isolated popliteal segment: is polytetrafluoroethylene graft acceptable?

In a series of 148 polytetrafluoroethylene femoropopliteal bypasses performed for limb salvage, 33-month life-table cumulative patency rates for grafts inserted into an isolated popliteal artery segment (91% +/- 5%) were not significantly different from those inserted into a popliteal segment with angiographically better runoff (78% +/- 5%). Similarly, below-knee reconstructions had 3-year patency rates (86% +/- 6%) that were not significantly different from those for bypasses inserted into the popliteal artery above the knee (79% +/- 6%). One clear disadvantage of the isolated popliteal artery segment as a site for distal insertion of the bypass was the increased incidence of limb loss despite a patent reconstruction. This was particularly frequent in diabetics with extensive foot gangrene or infection and could be avoided by a secondary extension of the bypass to a patent distal leg or foot artery.

Aged↗
PubMed1980

Combined effect of metals on biogenic amines and their distribution in the brain of mice.

The toxic effects of manganese in combination with iron or copper on the brain tissue of mice were investigated. The combined administration of manganese and iron decreased the accumulation of manganese in the brain compared to manganese treatment alone. This indicated that excess iron may influence the absorption of manganese. Combined exposure to manganese and copper resulted in marked accumulation of copper in the brain. This is of great concern, since excess copper in brain produces incoordination in body movements. Thus, the combined exposure of these two metals, even in permissible limits, may produce serious brain dysfunctions. The combined administration of manganese with iron or copper has also significantly altered the levels of brain tryptophan and 5-hydroxytryptamine.

Animals↗
PubMed1980

Three year experience with expanded polytetrafluoroethylene arterial grafts for limb salvage.

Polytetrafluoroethylene grafts were used for 175 femoropopliteal reconstructions with a cumulative 3 year life table patency rate of 77%. Reoperation for early or late failure was required in 27 patients to achieve this patency rate. If these 27 failures were calculated as nonpatent grafts, 3 year patency would be 62%. Thirty month life table patency rates were 94 and 91% for polytetrafluoroethylene axillofemoral and femorofemoral bypasses, respectively. Twenty-two polytetrafluoroethylene axillopopliteal bypasses were performed because of infection in the groin, previously failed reconstructions or unavailability of femoral vessels due to disease. The 2 year life table patency rate was 69%, with nine of the grafts patent for more than 1 year. Forty polytetrafluoroethylene bypasses to arteries at the ankle or in the foot resulted in a 2 year life table patency rate of 48%. Thus, polytetrafluoroethylene grafts show early promise as a vascular prosthesis. Although further study will be required to define the exact role of this new arterial substitute, it already can facilitate the performance of otherwise difficult or impossible limb salvage procedures.

Axillary Artery↗
PubMed1980

The effect of manganese administration, alone or combined with zinc, mercury and cadmium, on the tissue levels of these elements in rats.

Manganese chloride was administered alone or in combination with zinc chloride, mercuric chloride and cadmium chloride i.p. to rats for 30 days to investigate the effect of interaction of these elements on their content in brain, liver and kidney. Significant changes in the accumulation of these metals after combined exposure indicated that metabolic interactions occur. Alterations in the tissue contents of manganese, zinc, mercury and cadmium after combined administration may reflect changes at the absorptive sites or in excretory pattern.

Animals↗
PubMed1980

Neuromelanin in manganese-exposed primates.

Monkeys developed muscular weakness and rigidity of the lower limbs after 18 months exposure to manganese. These are neurological signs typical of chronic manganese intoxication. Marked neuronal degeneration with depigmentation was noticed in the region of substantia nigra. Significance of depigmentation in relation to the depletion in the contents of brain dopamine in chronic manganese intoxication has been discussed.

Animals↗
PubMed1980

Symptomatic vertebral haemangiomas.

Twelve cases of symptomatic vertebral haemangioma are reported in respect of their clinical presentation and radiological findings. One patient was only 10 years old, the youngest patient ever reported. Less commonly known findings of associated paravertebral mass and the displacement of the thoracic paraspinal line are discussed.

Adult↗
PubMed1980

Manganese induced testicular changes in monkeys.

Oral administration of manganese chloride (25 mg/kg b. w. daily) to monkeys for a period of 18 months produced congestion and marked increase in weight of testis. Histopathologic examination revealed interstitial oedema and degeneration of seminiferous tubules. Activities of succinic dehydrogenase, glucose-6-phosphate dehydrogenase and acid phosphatase were significantly inhibited whereas NADH-diaphorase and alkaline phosphatase activities showed only slight inhibition in seminiferous tubules of treated monkeys. It was concluded that chronic exposure to manganese does not produce sever degenerative changes in the testis earlier than metal induced encephalopathy in primates.

Acid Phosphatase↗
PubMed1980

Urethral diverticulum in male subjects: report of 5 cases.

We present 5 cases of urethral diverticulum in male subjects, of which 2 were congenital and 3 were acquired. Of these diverticula 4 were in the anterior urethra, while 1 was in the posterior urethra. One congenital diverticulum contained multiple calculi.

Adolescent↗
PubMed1980

Health risks in ultra-low-volume (ULV) aerial spray of malathion for mosquito control.

A field study was undertaken to evaluate health risks in persons engaged in ultra-low-volume (ULV) aerial application of technical malathion for mosquito control. No specific toxicity signs and symptoms were observed except nausea and irritation of eyes in a few cases. Observations on the ChE activity has revealed a significant depression in plasma at the end of spray operation in labourers employed in loading and unloading of insecticide and in field workers. Red blood cells ChE activity was not affected in any group of subjects. At the end of spray operation the insecticide residue on the grass used as cattle feed were about 315 ppm, which are much above the permissible level. However, 4 days after the application normal levels of the insecticide residues were detected.

Agriculture↗
PubMed1980

Effect of lindane on antibody response to typhoid vaccine in weanling rats.

The immunosuppressive effect of lindane was assessed in weanling rats over a period of 5 weeks. Agglutinin titres against S. typhi 'O' and 'H', S. paratyphi 'AH' and 'BR' antigens were determined following TAB vaccination in control and lindane-fed animals. The titres attained in non-treated controls were higher significantly than those in treated animals indicating a suppressive effect of lindane on humoral immune responses.

Animals↗
PubMed1980

Increased susceptibility of rabbits to intravenous challenge with Mycobacterium avium after mild hepatitis produced by carbon tetrachloride.

A mild grade of liver damage in rabbits was produced by giving 23 subcutaneous injections of carbon tetrachloride (CCl4). The CCl4-treated rabbits and untreated controls were subsequently challenged with the mildly virulent strain of Mycobacterium avium Kirschberg (TMC 801). In two successive experiments it has been found that liver damage increased the susceptibility of rabbits to infection with this organism.

Animals↗