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Biomedical subjects

S Jensen

Publications and source records attributed to S Jensen.

At least 145 records · Page 8Linked to original sources
PubMed1985

Clinical effects of enteral and parenteral nutrition preceding cancer surgery.

Parenteral and enteral nutrition have become major tools in the nutritional management of cancer patients perioperatively. The purpose of this article is to see if there is evidence from prospective controlled trials that parenteral and enteral nutrition preceding cancer surgery are of clinical benefit. From our investigation and from 8 other controlled, randomized clinical investigations the following conclusions can be drawn: Parenteral and enteral nutrition preceding cancer surgery improve nutritional parameters; Parenteral and enteral nutrition preceding cancer surgery may decrease postoperative morbidity and mortality, but this beneficial effect may not be limited to malnourished patients; If enteral nutrition can provide the same amount of proteins and calories as parenteral nutrition can, parenteral and enteral nutrition are equal with regard to clinical effects.

Combined Modality Therapy↗
PubMed1984

Intraocular grafts of fresh and freeze-stored rat hippocampal tissue: a comparison of survivability and histological and connective organization.

Intraocular grafts of rat hippocampal tissue, grafted either directly from the immature donor brains (fresh) or after storage in liquid nitrogen at -196 degrees C (freeze-stored), were compared with regard to survivability and histological and connective organization. For direct grafting, pieces of hippocampal tissue from rat embryos (embryonic day 19, E21) and newborn rats (PO) were placed in the anterior eye chamber of adult rats immediately after dissection. For grafting after deep-freeze storage, pieces of hippocampal tissue were taken from rat embryos (E16-E21) and newborn rats (PO), frozen at a cooling rate of 1 degrees C/min in CO2 or N2 vapours after addition of the cryoprotective agent dimethylsolfoxide (DMSO), and stored in liquid nitrogen for 1 to 33 days before thawing and intraocular grafting. From 20 to 68 days after grafting, the recipient rats were sacrificed, their eyes sectioned, and the sections stained with thionine for cell bodies, Timm's sulphide silver method for hippocampal fiber systems and terminal fields, and acetylcholinesterase (AChE) for cholinergic fibers and AChE-positive neurons. When examining the 101 grafted eyes (34 grafted with fresh and 67 with freeze-stored tissue) a significantly lower survival rate of the freeze-stored tissue was found (28 vs. 88%). The survivability of the freeze-stored tissue was age-dependent with no survival at donor ages E16 and PO, while tissue from E18-E21 had a 50% survival rate. The grafts of the freeze-stored tissue were also smaller and showed an increased tendency for fragmentation. When evaluating the structure of the grafts, the deep-freeze storage was found primarily to have been harmful to the dentate granule cells and their precursors. The organization of intrinsic fiber connections followed the pattern known from lesion and intracerebral transplant studies. While demonstrating that immature brain tissue can survive deep-freeze storage and subsequent intraocular grafting, the study also indicates that different schemes may have to be used to get optimal survival of different neuronal populations.

Animals↗
PubMed1982

Identification of acetylcholinesterase and cholinesterase in amniotic fluid by immune absorption technique.

A method for immunological detection of acetylcholinesterase (AChE) and cholinesterase (ChE) in amniotic fluid is described. By addition of a small amount of antihuman-erythrocyte membrane antibody or anti-pseudocholinesterase antibody to the sample before electrophoresis the two esterase bands on polyacrylamide gel (PAG) can be absorbed away. Similar staining results can also be obtained by specific inhibition of the two esterases with either BW 284C51 (AChE inhibitor) or Lysivane (ChE inhibitor). In cases with a faint AChE band and in cases with blood contamination the immune absorption technique makes interpretation easier. Nearly identical staining results have been obtained by the immune absorption technique and the inhibition technique in the following samples with an AChE band: 34 samples from pregnancies with severe fetal malformation or intrauterine death (2 cases), 4 fetal serum samples, 4 samples of cerebrospinal fluid, 4 samples of fetal erythrolysate and 4 samples of adult erythrolysate. It can be concluded that an antibody prepared against erythrocyte AChE cross-reacts with AChE in cerebrospinal fluid, and that this antibody can be used for demonstration of AChE in amniotic fluid.

Acetylcholinesterase↗
PubMed1982

The effect of etidronate disodium (EHDP) on retinopathy in insulin-dependent diabetic patients.

In a randomized double-blind study the effect of etidronate disodium (EHDP) on retinopathy, plasma inorganic phosphate and blood oxygen transport was assessed in 26 insulin-dependent diabetic patients. Following 6 months of EHDP administration, plasma inorganic phosphate had increased significantly (1.48 vs 1.14 mmol/l; P less than 0.01). Red cell, 2,3-diphosphoglycerate concentration (16.9 vs 15.1 mumol/g Hb; P less than 0.01) and the haemoglobin-oxygen affinity measured by pO2 at 50% oxygen saturation (P50) had also increased significantly (27.5 vs 26.3 mmHg; P less than 0.01). No changes had occurred in mean blood glucose and haemoglobin A1c concentrations, indicating a comparable degree of glucose regulation. Following 6 months of EHDP administration an association was found between improvement in retinopathy and the increase in plasma inorganic phosphate.

2,3-Diphosphoglycerate↗
PubMed1982

Differentiation of neurons containing olfactory marker protein in adult rat olfactory epithelium transplanted to the anterior chamber of the eye.

Olfactory marker protein is a cytoplasmic component unique to fully-differentiated olfactory sensory neurons. It has been proposed that expression of this protein occurs only if the neurons make synaptic contact with the central nervous system. In the present experiments, adult olfactory epithelium was transplanted as an autograft to the anterior chamber of the eye. This procedure destroys the mature sensory neurons, which are subsequently replaced by division and differentiation of stem cells. The newly-formed sensory neurons differentiate sufficiently to produce olfactory marker protein, without apparently contacting central nervous tissue. We conclude that contact with the central nervous system is not necessary for expression of olfactory marker protein.

Animals↗
PubMed1982

Use of midazolam as an induction agent: comparison with thiopentone.

A prospective, randomized, single-blind investigation was undertaken into the value of midazolam as an agent for the induction of anaesthesia. Sixty patients undergoing orthopaedic surgery of short duration were allocated randomly to receive either midazolam 0.2 mg kg-1 or thiopentone 3 mg kg-1. The induction time (measured as the time until loss of eyelash reflex) in the thiopentone group was significantly shorter than in the midazolam group. No differences were observed between the two drugs as regards time to onset of apnoea, or changes in heart rate and arterial pressure.

Adult↗