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Biomedical subjects

S Jain

Publications and source records attributed to S Jain.

At least 595 records · Page 33Linked to original sources
PubMed1987

Herpes simplex virus type-2 encephalitis in peripartum period preceded by hepatitis.

Encephalitis by Herpes Simplex virus type-2 in adults is rare and has been described as part of a disseminated infection in settings of immunosuppression, pregnancy being one of them. The virus was isolated from CSF of a young female, who during puerperium, presented with hepatitis, encephalitis and subsequently developed persistent vegetative state. Case history of another woman at term pregnancy is described who had similar illness but virological proof could not be obtained.

Adult↗
PubMed1987

Mitomycin C associated hemolytic uremic syndrome.

Mitomycin C associated Hemolytic Uremic Syndrome (HUS) is a potentially fatal but uncommon condition that is not yet widely recognised. It consists of microangiopathic hemolytic anemia, thrombocytopenia and progressive renal failure associated with mitomycin C treatment and affects about 10% of patients treated with this agent. The renal failure usually develops about 8-10 mth after start of mitomycin C treatment and the mortality is approximately 60% from renal failure or pulmonary edema. Renal lesions are similar to those seen in idiopathic HUS and include arteriolar fibrin thrombi, expanded subendothelial zones in glomerular capillary walls, ischemic wrinkling of glomerular basement membranes and mesangiolysis. The mechanism of action is postulated as mitomycin C-induced endothelial cell damage. We describe the clinical course and pathological findings in a 65 yr-old man with gastric adenocarcinoma who developed renal failure and thrombocytopenia while on treatment with mitomycin C and died in pulmonary edema.

Aged↗
PubMed1987

Elucidation of the receptors in macrophage and Plasmodium yoelii interactions.

Binding of hyperimmune serum opsonized merozoites of Plasmodium Yoelii nigerensis to trypsinized macrophages suggested it to be mediated by FcII receptor. Receptor blocking inhibition with monoclonal antibody 2.4G2 directed against Fc receptor for IgG1/IgG2b provided evidence that Fc delta 2b on macrophage played an important role in the merozoite-macrophage interactions. In addition, a neuraminidase sensitive receptor was noted to mediate the binding of P. yeelii merozoites in the absence of serum. Binding inhibition studies with two monosaccharides, D-mannose and alpha-methyl mannoside, indicated the role of Mannose/Fucose receptor on macrophage in this interaction.

Animals↗
PubMed1986

Serum glycolytic enzymes in breast carcinoma.

Serum levels of lactate dehydrogenase and its isoenzymes, phosphohexos isomerase, aldolase and hexokinase were determined in 152 cases of breast carcinoma, in search of proper diagnostic and prognostic parameters. The enzyme levels showed a relation to the clinical stage of the tumor and were, on an average, higher in advanced stages of disease. Phosphohexose isomerase and lactate dehydrogenase-isoenzyme levels were of best diagnostic significance even at an early stage of the disease. The enzyme levels correlated well with the prognosis of the disease. In group three, the prognosis was very poor and the patients responded only slightly to the treatment, and only up to the third month; after that enzyme levels again increased.

Breast Neoplasms↗
PubMed1986

Markov chain model and its application.

This paper examines the use of the Markov chain model to study the condition of asthma patients with respect to seasonal variations. The model can be utilized for predicting the health status of these patients.

Asthma↗
PubMed1986

A comparison of pulmonary function tests for postthoracotomy pain using cryoanalgesia and transcutaneous nerve stimulation.

The beneficial effects of transcutaneous nerve stimulation (TNS) and cryoanalgesia for post-thoracotomy pain were compared against each other and against a control group through pulmonary function testing in the immediate and delayed postoperative period. Patients receiving cryoanalgesia did not perform well in the first 24 hours after operation. However, by the fifth postoperative day, they did as well as or even better than the TNS patients. Both cryoanalgesia and TNS were significantly effective in the management of postoperative pain as compared with controls.

Electric Stimulation Therapy↗
PubMed1986

Influence of malarial infection on the maternal-foetal relationship in pregnant mice.

Pregnant mice infected on gestation day (GD) 6 with Plasmodium berghei showed a more rapid rate of increase in parasitaemia than mice infected later in pregnancy or non-pregnant controls. All mice infected on GD 6 were dead by the 7th post-infection day. Pregnant mice infected on GD 13, in contrast, had similar rates of parasitaemia and mortality as non-pregnant controls and 50% delivered normally, the foetuses were absorbed in 20% and 30% died before parturition. The pups born to mice infected on GD 13 were smaller. This compromised foetal development was likely to be the result of maternal anaemia, hyperplasia of placental trophoblast and plugging of placental sinusoids with parasitized red cells.

Animals↗
PubMed1986

Aleukaemic leukostasis in a case of large cell non-Hodgkin's lymphoma: report of a case with a distinctive central nervous system involvement.

A 52-year-old man with large cell non-Hodgkin's lymphoma developed a unique pattern of central nervous system involvement by lymphoma while in apparent systemic remission. Despite intermittent neurological episodes suggestive of CNS involvement by lymphoma no evidence of CNS lymphoma was found on repeated cerebrospinal fluid and brain CT scan examinations. At necropsy widespread occlusion of cerebral blood vessels by malignant lymphoid cells was observed with extensive tissue necrosis and haemorrhages. Leukaemic involvement of peripheral blood was not detected on repeated blood film examinations during life.

Brain↗
PubMed1986

Cerebrovascular diseases: a review of the Indian experience in the last 35 years.

The relevant literature on cerebrovascular diseases from the Indian subcontinent in the last 35 years has been reviewed. Most of the data available are from retrospective studies carried out in various large urban hospitals. The incidence of stroke reported is less when compared with western figures, which may be a reflection of the population at risk. The incidence of stroke in the young Indians below the age of 40 years is higher compared to other countries, which again may be a statistical aberration or may be due to local aetiological factors. Ischaemic cerebrovascular complications of pregnancy and puerperium occur frequently, but the total picture is probably the same as elsewhere in the world.

Age Factors↗