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Biomedical subjects

S Ivanov

Publications and source records attributed to S Ivanov.

At least 91 records · Page 5Linked to original sources
PubMed2000

[Mercilon - the optimal oral contraceptive].

The authors review the effect of the oral contraceptive Mercilon on menstrual cycle, contraceptive efficacy, lipid profile, safety profile and adverse effects in a group of 32 women, included in the survey. The results of the trial show excellent contraceptive effect with Pearl Index of 0.00 and good control over the menstrual cycle. No negative or unfavorable effects were seen on the lipid profile as well as on the liver kidney and coangulant system function. Minor side effects were seen in only 5% of the patients.

Adult↗
PubMed1999

[The use of hysterosonography and transvaginal sonography in combination with the progesterone test in asymptomatic women in risk groups in the postmenopause].

The hysterosonography allows evaluation of the endometrial cavity by endouterine administration of sterile physiologic solution. We wanted to assess the role of the hysterosonography and the transvaginal ultrasonography in asymptomatic women in post-menopause in combination with progesterone test. The progesterone test was performed by border of the endometrial depth of 4 mm, we used progesterone tablets Primolut Nor for 10 days., by depth 5 mm and over. Under the border of 4 mm we assessed the endometrium as atrophic. When bleeding occurred we used transvaginal sonography in combination with hysterosonography and in this way were better visualised the sub-mucous uterine fibroids nodes and also very small lesions., and endometrial cancers. The transvaginal sonography allowed to measure better the endometrial depth and in combination with the hysterosonography provided very good information. One hundred postmenopausal women from the risk groups with diabetes, blood hypertension, obesity and treated with Tamoxiphen were subjected to transvaginal sonography by endometrial depth of 4 mm we used progesterone test. -so it was used by 5 mm and over When bleeding occurred we performed abrasio probatoria separata The hysterosonography was used as additional method for clearing and determining of some polyps and very small lesions. The sensitivity of the transvaginal sonography was compared with the hysterosonography and was nearly the same--91% resp. 94%. The specificity was 31% for the transvaginal sonography. The combining of the transvaginal sonography and hysterosonography increased the sensitivity up to 96% and the specificity up to 98%. The hysterosonography can be additional method for diagnose of focal lesions, because of the good shape and forms of the lesions, especially in some risk groups receiving Tamoxiphen, with diabetes mellitus, blood hypertension and obesity patients.

Adenocarcinoma↗
PubMed1999

[The treatment of acute mycotic colpitis with ciclopiroxolamine (Dafnegin-CSC) in pregnant patients in the 10th lunar month].

Thirty-four patients at the end of pregnancy were treated with ciclopiroxolamine (Dafnegin) vaginally for the period from January to October 1998. The effect of therapy was evaluated. One hundred women were examined and 34 (34%) of them had vaginal candidiasis. All patients were treated with ciclopiroxolamine (Dafnegin) vaginal creme once time daily for 14 days. Thirty-two patients (94.11%) were healthy, in two patients (5.88) candidiasis was reduced to minimal colonies.

Acute Disease↗
PubMed1999

[The progesterone test and transvaginal sonography as methods for the early discovery and screening of endometrial cancer in women in the postmenopause from some risk groups].

We wanted to assess the effect of tamoxifen treated women with breast cancer, as well as to examine patients with diabetes blood hypertension, and obesity. The influence of Tamoxifen was searched over the endometrium in patients treated with it for 3 years. In this research work is assessed the effect of this medicament from this risk group. The second risk group were the women with high blood pressure, obesity and diabetes mellitus. We used transvaginal sonography and the progesterone test to find endometrial pathology and especially endometrial cancer in asymptomatic women-measuring the depth of the endometrium, and using abrasio probatoria separata in order to find endometrial cancer. With these tests we found polyps, hyperplasia, and early endometrial cancer. We wanted with progesteron test and vaginal sonography in these risk groups to find endometrial pathology and especially early endometrial cancer in asymptomatic women.

Antineoplastic Agents, Hormonal↗
PubMed1999

[Carcinoma of the vagina].

In our study we present the cases with vaginal cancer treated in the gynaecological clinic of the National Oncological Centre in Sofia for the period from 1989 till 1998. Most of the women were with squamous cell carcinoma of the vagina. Twenty seven patients were examined--19 of them were operated, 18 patients received radiotherapy and 2 chemotherapy. The tumors that were localized in the upper 2/3 of the vagina were operated by radical hysterectomy a modo Wertheim-Meigs and extirpation of the vagina. When the tumor was localized in the lower third of the vagina we performed additionally radical vulvectomy and bilateral inguinofemoral lymph-node dissection. For more advanced cancers we did exenteration anterior and posterior. When there was no possibility for surgical approach or for radiotherapy we did chemotherapy with 5-Fu, methotrexate, cyclophosphamide and vincristin. The prognosis for the vaginal cancers is not good, in 25-30% of the patients survive 5 years. As a whole we assess that we are having the same results, as well as survival rate like other western clinics.

Carcinoma↗
PubMed1999

[Prognostic factors in endometrial carcinoma].

In our study we tried to give more light and information about the most frequent prognostic factors in endometrial cancer. The evaluation of 500 patients and all possible prognostic factors gave us the opportunity to treat better and to choose better therapy for our patients. The results were similar like other western clinics. The clinical and therapeutical administration of the classic and histological factors, as well as the biological markers was not in such wide study cleared up. That is why we did this research in order to, satisfy these scientific needs. The results did not differ from other western clinics working in this field.

Carcinoma↗
PubMed1999

[Primary hormone treatment of early endometrial cancer].

Six cases of primary treated endometrial cancer are included in this research work. Five of these women ended with tumour regression and 2 with pregnancies and deliveries of children. All of the women are still alive without having disease with mean follow-up period of 36.5 months (from 16 to 80 months). We consider that this is very promising method of treatment to offer y conservative treatment with high level of survival and possibility for having y child. Diagnostic and therapeutic data for the patients who are with early endometrial cancer and wish to have y child are analyised in this study. Four of the women were treated with GnRh-analogs-Zoladex and 2 with progestins-high doses.

Adenocarcinoma↗
PubMed1998

Isolation and characterization of [3H]fucose-labeled glycoproteins from the serum of normal rats and rats bearing Zajdela hepatoma.

Specific [3H]fucose-labeled glycoproteins were found in the serum of rats bearing Zajdela hepatoma, which possess different isoelectric points in comparison with serum glycoproteins from normal rats. The electrophoretic profile of the serum glycoproteins is significantly altered. There is approximately a 2.5 times increase of [3H]fucose incorporation into serum glycoproteins from rats with an ascitic form of hepatoma, compared with normal rats and to animals bearing a solid form of the tumor (which have a considerably greater survival). Serum fucoproteins identical for the two forms of hepatoma were isolated, as well as glycoproteins strongly specific for each of the forms.

Animals↗
PubMed1998

[Malignant degeneration in women operated on for endometriosis].

UNLABELLED: The endometriosis can undergo estrogen-dependent changes similar to endometrium and may carry a risk for developing hyperplasia and carcinoma during unopposed estrogen stimulation. We reviewed the existing literature to analyze the potential of malignancy arising from extraovarian endometriosis by estrogen stimulation. Our two cases are also discussed. According to our study there are 21 cases published in the literature of malignant transformation of endometriosis after estrogen stimulation. The most common place for malignant trans formation is the vagina. The most common hystological type is adenocarcinoma in 13 cases. Our two cases were with adenocarcinoma and adenosquamous carcinoma. The incidence of malignant transformation of the endometriosis can not be estimated based upon these cases. There is a need for randomised clinical trials. CONCLUSIONS: The estrogen stimulation may lead to premalignant or malignant transformations of the residual foci of endometriosis. That is why addition of progestins to the estrogen substitutional therapy should be considered in women with endometriosis after total hysterectomy with oophorectomy, especially if a residual foci are present or suspected. With our study we think we can make more clear the way an endometriosis is transformed into a malignancy.

Adenocarcinoma↗
PubMed1998

[The structure and incidence of the basic causes of maternal mortality].

The author treats by the presented scientific publication the structure and frequency of causes for maternal mortality in particular countries and mainly in Bulgaria. Several structure types of maternal mortality are examined--"extragenital", "hemorrhagic", "septic". It has been proven through a close examination of the work of women's consultation cabinets with regard to maternal mortality that a considerable dependence and regularity is determined due to the insufficient coverage of women from housing complexes (only 24.9% have 6-14 visits). For 1995 dead pregnant women, women in delivery and young mothers in particular regions are 0.1 for 1000 from 73,032 checked-up women. Only in Sofia and Montana region the mortality rate is 0.2 for 1000. For 1996 the mortality rate in the presented regions (see Table N1) for pregnant women, women in delivery and young mothers has increases to 7 (0.2 for 1000).

Bulgaria↗
PubMed1998

[The characteristics of the perinatal period in women whose death is related to pregnancy, labor and puerperal pathologies].

Mortality rate of the hospitalized for delivery women depends on their condition before entrance into hospital. This indicator is also related to the possibilities of Ob./Gyn. clinics to provide highly qualified assistance as well as to the prophylactics, dispensary and partronage work and activity of the women's consultation cabinets. Table N1 is of interest as it presents the prevention of death/complication that caused death/of dead pregnant women, women in delivery and young mothers. We accept that unpreventation of death is owed mainly to some medical and biological causes and to the advent of severe irreversible damages of organs of vital importance. An issue of interest to the clinician and to the maternal health care are the periods, in which pregnant women and young mothers--before delivery, during delivery, after delivery and in the first month after month after delivery most frequently die (tab. N 2).

Bulgaria↗
PubMed1998

[The evaluation of the transvaginal ultrasonography of endometrial thickness in women with postmenopausal bleeding and suspected endometrial carcinoma].

The aim of our research work was to assess the transvaginal ultrasonography for measurement of endometrial thickness in women with postmenopausal bleeding, and in this way to determine the less invasive treatment. We wanted to make a grading of endometrial cancer, in order to choose patients who need pelvic and para-aortal lymph dissection. We examined 84 patients by ultrasonography and histological examination of the endometrium. Under 8 mm thickness were not found precancer and cancer lesions. The mean endometrial thickness was 8.25c1.63 mm, while in non pathological lesions was 1.36c1.10 mm. In order to diagnose endometrial pathology we determined border of 5 mm. Over 5 mm the ultrasonography has a 88.6% sensitivity, 90.6% specificity, 4.6% false negatives results--3 polyps, 1 glandular hyperplasia. Nevertheless that we determined border of 5 mm under which with great possibility there is no endometrial cancer, we don't support authors who advise not make a D&C. Future examinations in this field will give more light on this problem.

Carcinoma↗