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S Hashimoto

Publications and source records attributed to S Hashimoto.

At least 1,297 records · Page 72Linked to original sources
PubMed1983

[Urinary FDP].

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Female↗
PubMed1983

[Clinical significance of stress thallium-201 myocardial scintigraphy for evaluation of right ventricular ischemia].

Although stress thallium (T1)-201 myocardial imaging has been used for evaluation of the ischemic lesion of the left ventricle, there are few reports on the usefulness of this method for the assessment of the right ventricle in ischemic heart disease. The patients (pts) fell into three distinct groups according to the findings of the coronary arteriogram: normal control group (16 cases) without angiographically documented coronary artery disease; non-RCA group (16 cases) with a significant stenosis (greater than or equal to 75% narrowing) in the left coronary artery but free of a significant right coronary artery (RCA) stenosis; RCA group (28 cases) with a significant RCA stenosis regardless of the presence or absence of a significant left coronary artery lesion. After the pts were exercised to 80-85% of the expected maximum heart rate, immediate and delayed (3 to 4 hrs) T1-201 myocardial images were obtained. The images of the right ventricular free wall ( RVFW ) in 30 degrees and 60 degrees left anterior oblique (LAO) projections were evaluated visually with regard to the presence or absence of a defective T1-201 uptake, degree of the radioactivity and redistribution phenomenon of the RVFW . On immediate images, all normal controls and 13 pts in non-RCA group had continuous visualization of the RVFW . In RCA group, the RVFW was not visualized in five and 11 showed defective visualization of the RVFW in the 30 degrees LAO projection. In 60 degrees LAO projection, the RVFW was not visualized in six and five had defective visualization. On delayed images in RCA group, two pts who had no inferior myocardial infarction (MI) had redistribution of T1-201 into the RVFW . Defective visualization of the RVFW on the image was associated with location of the RCA lesion, history of inferior MI and degree of RCA stenosis. Collateral circulation seemed to protect the RVFW against the development of exercise-induced ischemia and affect the occurrence of redistribution of T1-201 into the RVFW . The RVFW findings on images improved the sensitivity for identifying the pts with RCA disease, compared with the LV findings alone. Thus, stress T1-201 myocardial imaging is able to visualize the myocardial blood flow of the RVFW and may provide a useful non-invasive method in the evaluation of right ventricular ischemia.

Adult↗
PubMed1983

Potentiation of antitumor immunity in tumor-bearing mice by a degraded D-manno-D-glucan (DMG), a new antitumor polysaccharide.

DMG, a degraded D-manno-D-glucan from the culture fluid of Microellobosporia grisea, inhibited the growth of murine syngeneic MM46 mammary carcinoma. Mice in which the tumor had completely regressed by DMG treatment showed tumor-specific antitumor resistance. The antitumor action of DMG was studied by examining the influences of DMG on tumor-specific and non-specific immune responses in tumor-bearing hosts. The tumor-specific delayed hypersensitivity reaction appeared transiently on day 7 after tumor inoculation but had decreased by day 15 in untreated tumor-bearing mice. In contrast, the reaction was retained and augmented in DMG-treated tumor-bearing mice. The tumor-neutralizing activity of spleen cells from DMG-treated tumor-bearing mice, tested by a Winn assay, was tumor-specific and significantly higher than that of untreated tumor-bearing mice. The tumor-neutralizing activity of peritoneal cells and the in vitro cytostatic activity of peritoneal macrophages in response to lymphokine supernatants containing macrophage activation factor were also augmented by DMG treatment. In contrast, the level of antitumor antibody in the serum increased with time, irrespective of DMG administration. Thus, DMG potentiated cellular antitumor effector mechanisms.

Animals↗
PubMed1982

Increase of fidelity of polypeptide synthesis by spermidine in eukaryotic cell-free systems.

The mechanism of spermidine-induced increase of fidelity of polypeptide synthesis in a wheat germ cell-free system has been studied. It was found that the increase of fidelity in the presence of spermidine occurred mainly at the level of binding of aminoacyl-tRNA to ribosomes, that reduction of misreading was more marked at the 5'-base than at the 3'-base of the codon and that misreading caused by paromomycin and kanamycin C was not significantly decreased by spermidine. It was deduced from these results that spermidine inhibited low-frequency misreading more strongly than high-frequency misreading. In addition, spermidine was found to stimulate the rejection of non-cognate aminoacyl-tRNA mainly at an initial discrimination step during the binding of amino-acyl-tRNA to ribosomes, and slightly at a subsequent GTP-dependent discrimination step, the so-called proofreading step. In yeast, rabbit reticulocyte, and Artemia salina cell-free systems, spermidine was found to increase the fidelity of protein synthesis.

Animals↗
PubMed1982

Inhibitory mechanism of dipyridamole on platelet aggregation ex vivo.

The effects of dipyridamole on platelet aggregation ex vivo and in vitro and on platelet cyclic AMP phosphodiesterase (PDE) were studied, and the mechanism of the ex vivo effects was assessed. Both the ADP- and collagen-induced aggregations ex vivo were inhibited dose-responsively by oral administration of dipyridamole. Maximum dipyridamole levels in the plasma were reached at 30 min after the administration. The inhibitory effects of dipyridamole on platelet aggregation ex vivo reached a maximum at between 1 and 2 hrs. On the other hand, the ADP-induced aggregation in vitro and cyclic AMP PDE activity were not inhibited until after 10 min of incubation at a low concentration of dipyridamole. This mode of inhibition of platelet aggregation in vitro and of cyclic AMP PDE activity agreed with the mode of inhibition in the case of platelet aggregation ex vivo. It is suggested therefore that the ex vivo effects, observed with only a low dipyridamole concentration in the plasma, may be due primarily to inhibition by dipyridamole of the cyclic AMP PDE in platelets.

Adenosine Diphosphate↗
PubMed1982

Computed tomography of malignant tumors of the nasal cavity and paranasal sinuses.

Staging of malignant tumors of the nasal cavity and paranasal sinuses by computed tomography (CT) was studied in a total of 49 patients, 33 with squamous cell carcinoma and 16 with tumors of other histologic types. Involved sites by the tumor were studied, and clinical staging was made using CT findings alone according to AJC classification for maxillary sinus tumors. Surgical findings for comparison were available for most cases. Of 33 squamous cell carcinomas and of 16 tumors with other histologic types, the maxillary sinus was the site of origin in 29 and eight, respectively. Of these 37 maxillary sinus tumors, 11 were staged T3, 26, T4, and none was staged T1 or T2. None of these tumors were down staged, and one T3 was upstaged after surgical procedures, although all sinuses were not explored in some cases. Sinusitis due to obstruction was indistinguishable from the tumor without bone destruction. And the determination of the site of origin was difficult in some cases. Despite these, CT should be used for pretreatment evaluation of the tumors of these sites.

Adenocarcinoma↗
PubMed1982

[Clinical study on the angiotensin I-converting enzyme in human urine. (I) Partial purification, enzymic characteristics and excretion in normal subjects].

The angiotensin I-converting enzyme in normal human urine was partially purified with ammonium surfate (3.2M), DEAE-Cellulose ion exchange chromatography (0-0.5M NaCl gradient), and Sephadex G 200 gel filtration. The enzyme was separated into three forms which had different molecular weights of 700000, 290000 and 40000, respectively. The enzymic biochemical characteristics of these three enzymes, however, were identical with regard to their inhibitory effects (bradykinin potentiator c, arg-pro-pro, o-phenanthroline and EDTA), Cl- dependency, optimal pH (8.3) and temperature (37 degrees C), and Km value (2.3mM). The enzymic activity was determined in five normal subjects in three conditions of dietary sodium intake (51, 153 and 340mEq for 5 days, respectively). The enzymic activity correlated well with the concentration of the excreted sodium (r = 0.87, p less than 0.001). There was no significant relation between the enzymic excretion and the concentration of the excreted potassium, nor between the activity and the creatinine excretion. It is suggested that the origin of urinary angiotensin I-converting enzyme is the kidney, and that the enzyme might regulate sodium excretion in cooperation with renal kallikrein-kinin system.

Adult↗