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Biomedical subjects

S Hashimoto

Publications and source records attributed to S Hashimoto.

At least 1,279 records · Page 71Linked to original sources
PubMed1983

Clinical significance of the right ventricular free wall appearance on stress Tl-201 myocardial images in ischemic heart disease.

In order to evaluate the clinical significance of thallium (Tl)-201 myocardial imaging for diagnosing the right ventricular (RV) ischemia, we studied the relationship of right ventricular free wall (RVFW) appearance on myocardial images to coronary arteriographic findings. Patients were divided into 3 groups as follows: 1) normal control (NC) group (19 cases) without angiographically documented coronary artery disease; 2) non-RCA group (18 cases) with significant coronary artery lesion restricted to the left coronary artery (LCA); and 3) RCA group (36 cases) with significant right coronary artery (RCA) stenosis regardless of underlying LCA disease. After the patients had exercised up to 80-85% of the predicted maximal heart rate, immediate and 3-4 hour delayed myocardial images were obtained. As for presence or absence of the RV ischemia on images, the RVFW appearance in 30 degrees and 60 degrees left anterior oblique (LAO) views were assessed carefully. On the immediate images, all patients except one in the NC group and all except 3 in the non-RCA group demonstrated 'continuous visualization' of the RVFW in both views. In the RCA group, 6 showed 'non-visualization' and 11 'defective visualization' of the RVFW in 30 degrees LAO view. In 60 degrees LAO view, 6 presented 'non-visualization' and other 6 'defective visualization' of the RVFW. On the delayed images, although none of the patients in the groups NC and non-RCA demonstrated redistribution phenomenon of the RVFW, 4 patients in the RCA group showed redistribution of Tl-201 into the RVFW. Non- and defective visualization of the RVFW on the immediate images were related to the proximally located RCA lesion, previous history of inferior myocardial infarction and high grade RCA stenosis. Collateral vessels seemed to protect the RVFW against the development of exercise induced ischemia and affect the occurrence of redistribution of Tl-201 into the RVFW. In conclusion, stress Tl-201 myocardial imaging enables us to estimate the myocardial blood flow of the RV and is a useful non-invasive method in the evaluation of RV ischemia.

Adult↗
PubMed1983

A new method for quantitative analysis of thallium-201 myocardial image-"corrected" circumferential profile method.

A new method for computer-assisted quantitative analysis of a thallium (Tl)-201 myocardial image ("corrected" circumferential profile method) was described. Since the Tl-201 myocardial image of a normal subject is not homogeneous, an attempt was made to correct for this non-homogeneity. Three groups of subjects were studied, including 10 normal volunteers (group A, mean age of 27.5 years), 14 patients with atypical chest pain and normal coronary arteriogram (group B, mean age of 56.7 years) and 16 patients with first transmural myocardial infarction (group C, mean age of 71.0 years). The myocardial images were acquired at rest at anterior, left anterior oblique (30 degrees and 60 degrees) and left lateral projections. With a scintigram, the left ventricle was outlined and divided into 24 radial segments by radii drawn from the center of the left ventricle. Average radioactivity per pixel in normal subjects was obtained in each segment and normalized to the highest segment (= 100%). The ratio of 100% to the mean of normalized radioactivity in percent in each segment from 10 normal volunteers was calculated and designated as a correction factor for each segment. After the correction of average radioactivity per pixel in each segment using this correction factor and after relating it to the highest radioactive segment, the mean (= 100%) and standard deviation (SD) were calculated and (100-4SD)% was defined as the normal lower limit. In the scintigram of groups B and C, "corrected" circumferential profiles were obtained from the regional radioactivity multiplied by the correction factor, normalized to the highest segment (100%) and compared with the lower normal limit. The ratio (%) of the area of patient's circumferential profile curve below the normal limit to the total area below the normal limit was obtained at each view and the sum of them was called the total "corrected" defect score. Infarct size analyzed by the "corrected" circumferential profile method correlated well with that analyzed by visual interpretation, and was useful in differentiating group C from group B.

Adult↗
PubMed1983

Effects of metoclopramide, a dopamine antagonist, on secretion of aldosterone and renin release in patients with primary aldosteronism.

To assess the interaction between dopamine and aldosterone secretion in primary aldosteronism, the dopamine antagonist, metoclopramide (methoxy-2-chloro-5-procainamide), was given as an i.v. bolus (10 mg) to 5 patients with primary aldosteronism and 5 normal subjects treated with dexamethasone (2 mg/day) to eliminate an influence of ACTH. Metoclopramide increased plasma aldosterone concentration (PAC) in primary aldosteronism from 39.1 +/- 15.5 to 42.5 +/- 15.9 ng/100 ml (p less than 0.05) and also from 12.9 +/- 2.3 to 23.6 +/- 3.4 ng/100 ml (p less than 0.01) in normal subjects at 15 min. Plasma renin activity (PRA), and plasma concentrations of cortisol, potassium, and sodium did not significantly change with metoclopramide in either primary aldosteronism or normal subjects. Plasma prolactin increased by 12- and 20-fold in primary aldosteronism and in normal subjects, respectively, but there was no significant positive correlation between changes in PAC and in plasma prolactin in either primary aldosteronism or normal subjects. It is suggested that dopamine inhibits the secretion of aldosterone in primary aldosteronism as well as in normal subjects. It seems unlikely that dopamine affects the release of renin in primary aldosteronism.

Adrenocorticotropic Hormone↗
PubMed1983

Value of computed tomography for radiation therapy of tumors of the nasal cavity and paranasal sinuses.

The role of computed tomography (CT) in connection with irradiation was evaluated in 60 patients with malignant tumors of the nasal cavity and paranasal sinuses. The extent of the tumors was well demonstrated at CT. The infratemporal fossa was involved in 33 patients, extension to the intracranial cavity was found in 6, and in 16 extension to the contralateral side. Such information is of great help in radiation treatment planning. On the other hand, CT was less valuable for evaluating the effect of radiation therapy.

Carcinoma, Squamous Cell↗
PubMed1983

Antitumor effects of novel immunoactive peptides, FK-156 and its synthetic derivatives.

Effects produced by intratumor or systemic application of FK-156 and its synthetic derivatives on the syngeneic P388-DBA/2 mouse system were investigated. Among 21 compounds tested, FK-156, FK-565, FR-46758, FR-48217, FR-46091 and FR-47920 substantially suppressed tumor growth when directly injected into a tumor mass and further experiments showed that FK-156, FK-565 and FR-46758 were effective even when administered subcutaneously into site remote from tumor. The mechanisms of growth inhibition are strongly suggested to be host mediated, because these three compounds have remarkably low cytotoxicity against P388 cells in vitro. A single dose of FK-565, however, markedly decreased body weight in healthy DBA/2 mice, whereas FK-156 and FR-46758 did not. These results indicate the superiority of FK-156 and FR-46758 as immunotherapeutic agents over FK-565 with respect to their safety for treatment of cancer. Although significant life-span prolongation could not be seen in the two-injection regimen of six compounds in either system, systemic multiple injections of FK-156 and FR-46758 provided a statistically significant increase in the median survival time of P388 tumor bearing mice.

Adjuvants, Immunologic↗
PubMed1983

Combination therapy of murine tumors with a degraded D-manno-D-glucan (DMG) from Microellobosporia grisea, and cyclophosphamide.

DMG, a degraded D-manno-D-glucan with a host-mediated antitumor activity did not significantly enhance nor inhibit the development of suppressor cells for either the antibody-forming response or the delayed hypersensitivity reaction to sheep red blood cells. Cyclophosphamide (CY), which inhibited the generation of suppressor cells, was combined with DMG in treatment of murine syngeneic tumors to obtain a higher antitumor activity. The antitumor activity of the combination against MH134 hepatoma was synergistically higher than that of either component alone. A marked antitumor effect of the combination treatment against MM46 mammary carcinoma was also shown. High levels of antitumor delayed hypersensitivity reactions were observed with this combination therapy. The possible roles of DMG and CY in this combination therapy are discussed.

Animals↗
PubMed1983

Normal titer of functional and immunoreactive protein-C inhibitor in plasma of patients with congenital combined deficiency of factor V and factor VIII.

Protein-C inhibitor (PCI) is a newly described plasma inhibitor directed against a vitamin-K-dependent serine protease, activated protein-C, which is involved in the inactivation of factor V and factor VIII. Marlar and Griffin have reported that PCI activity is absent in the plasma of patients with congenital combined factor V/VIII deficiency. We have measured the levels of PCI in the plasma of seven unrelated patients with this disorder using both functional and immunologic methods. The rate at which the amidolytic activity of activated protein-C was neutralized in the patients' plasma was essentially identical to that observed in normal plasma. The titer of PCI antigen, as measured by an electroimmunoassay using a monospecific anti-PCI serum, was 5.3 +/- 1.6 micrograms/ml in the patients' plasma and was not significantly different from that of normal plasma (5.3 +/- 2.7 micrograms/ml, n = 30). The levels of factor-V-related antigen, factor V coagulant antigen, and factor VIII coagulant antigen were low in all patient plasma and were in good agreement with their respective coagulant activity. Our results do not appear to support the hypothesis that combined factor V/VIII defect is due to a lack of PCI.

Antigens↗
PubMed1983

[Accumulation mechanism of 201Tl--K-contents and Na, K-ATPase activities of tissues].

Though the mechanism of 201Tl accumulation in thyroid tumours is not known yet, there are some hypotheses. In order to study the mechanism, potassium contents and Na, K-ATPase, of various organs of rats and human thyroid glands were analyzed . The conclusion through these experiments is as follows, 1 as the potassium contents and Na, K-ATPase activity of thyroid glands are not obviously higher than those of other organs, the 201Tl accumulation in thyroid is thought to be not owing to the similarity to the potassium ion, 2 pointing out high activity of Na, K-ATPase in heart and kidney, the accumulation mechanism of 201Tl in these organs has high relation to this activity, 3 though there is a tendency to have higher potassium contents among thyroid tumours, the difference in potassium contents between their histopathology is small; so that the tumour specificity is not explained from the potassium contents, and 4 as for Na, K-ATPase activity of thyroid tumours, papillary adenocarcinoma and follicular adenoma, which take more in 201Tl, have tendency to show higher activity; adenomatous goitre, which take less in 201Tl, has tendency to show lower activity. We suggested that the factor relating to the accumulation mechanism of 201Tl may be multiple, and Na, K-ATPase plays an important role in 201Tl specific uptake in thyroid tumours.

Adenoma↗
PubMed1983

A report of a case of T-cell-derived chronic lymphocytic leukemia with antibodies to adult T-cell leukemia-associated antigens.

A case of T-cell-derived chronic lymphocytic leukemia (T-CLL) with antibodies to adult T-cell leukemia (ATL)-associated antigens (ATLA) is reported. The patient had marked lymphocytosis consisting of peripheral cells that were shown to be T cells by their spontaneous sheep erythrocyte rosette formation and their OKT3 and OKT8 positivity, and in which ATLA were also detected after short-term culture of the cells in vitro. These findings suggest that adult T-cell leukemia virus (ATLV) might cause not only ATL but also some other lymphoid malignancies such as a type of T-CLL as in this case report. Nevertheless the occasional development of OKT8-positive T-CLL in a healthy carrier of ATLV in an ATL-endemic area cannot be disregarded.

Aged↗
PubMed1983

Hodgkin's disease in the endemic area of adult T-cell leukemia (ATL).

Antibodies to adult T-cell leukemia associated antigen (ATLA) in the sera from 14 patients with Hodgkin's disease (HD) were examined by the indirect immunofluorescence method. All patients were born in the ATL-endemic area, Kagoshima and Miyazaki prefectures, of Japan. Seven of the 13 evaluable patients (54%) gave positive reactions in the anti-ATLA test. Most of the positive patients were over 40 years of age and the positive rate in males was higher than that in females. The most interesting finding in the anti-ATLA positive patients was the presence of circulating abnormal lymphocytes which are usually found in ATL patients. Histological subclassification of the positive patients had no tendency to converge into a particular subclass of HD. Although there was no definite evidence to show an etiological relationship between ATL virus and HD, several findings in this study seem to suggest that in anti-ATLA positive patients, especially in the ATL-endemic area, the anti-ATLA positive state might have some inevitable influence on the natural history of their HD.

Adult↗