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Biomedical subjects

S Haddad

Publications and source records attributed to S Haddad.

At least 109 records · Page 6Linked to original sources
PubMed1985

Serum gastrin in chronic renal failure: morphological and physiological correlations.

Elevated serum gastrin (SG) has been reported in chronic renal failure (CRF). We studied SG levels in relation to various humoral and gastroduodenal histopathologic findings in 20 controls, 12 uremics under conservative therapy (CT), 27 patients on regular dialysis (RDT) and 8 transplanted patients (Tx). SG and parathyroid hormone (PTH) levels were estimated by radioimmunoassay (RIA), in addition serum BUN, creatinine, Ca++PO4---and alkaline phosphatase (predialysis in RDT) were determined. 20 patients (12 on CT and 8 on RDT) underwent pentagastrin (PG) stimulation test and upper gastrointestinal endoscopy with biopsy of gastric and duodenal mucosa. The mucosal samples were stained for mucopolysaccharides (MPS), nucleic acid (NA) and alkaline phosphatase (AP), and divided into intense, normal or faint staining. Mean SG was 688.71 pg/ml (CT cases), 636.2 pg/ml (RDT cases) and 280.6 pg/ml (Tx cases), all values being significantly higher than controls (118.46 pg/ml). SG level had a linear correlation with serum creatinine in CT patients and predialysis creatinine in RDT patients, but not with other parameters studied (BUN, Ca++,PTH,PO4---AP). The incidence of gastroduodenal erosions (40%) had a significant negative correlation with SG. They were more frequent with normal MPS stain (p = 0.01) and NA staining (p less than 0.001) than faint staining of gastric mucosa biopsy. The acid response to PG stimulation was inversely correlated with SG. We believe that elevated SG is compensatory to a decreased response of the gastroduodenal mucosa to PG. Mere retention of SG does not explain its elevation as its correlation with serum creatinine existed not only in patients on CT, but also in RDT patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Alkaline Phosphatase↗
PubMed1980

[Hypertension secondary to a "renin tumor". One case (author's transl)].

Eleven cases of hypertension secondary to a renal tumour secreting renin have been described in the literature between 1967 and 1978. The authors here report another case which presented with severe hypertension and a cerebrovascular accident in a 30-year-old woman. Intravenous urography and renal arteriography revealed a tumour of the upper pole of the left kidney. Estimation of renin levels in the renal veins demonstrated hypersecretion on the side of the tumour. Tumourectomy was followed by normalisation of blood pressure levels. Histological examination confirmed a diagnosis of a tumour of the juxtaglomerular apparatus.

Adult↗
PubMed1978

Bromocriptine in parkinsonism. A long-term study.

Bromocriptine was given in a controlled trial to 86 parkinsonian patients. Eight of 30 previously untreated patients with early and mild disease showed sustained benefit for two years and did not develop "on-off" effects or dyskinesias. Only two of 23 patients unable to tolerate or failing to respond to levodopa benefited from bromocriptine. Thirty-three patients with residual disabilities despite maximum tolerated doses of levodopa were also given bromocriptine: although benefit accrued, treatment was abandoned because of unacceptable side effects, and there was no improvement in the 11 with severe "on-off" disabilities. Although it was found that benefit from 70 mg daily of bromocriptine was comparable to that from 750 mg of levodopa with carbidopa, bromocriptine seems to offer no advantage to the majority of patients who have received or are receiving levodopa and/or carbidopa.

Anorexia↗
PubMedDate not supplied

CT in adnexal torsion with emphasis on tubal findings: correlation with US.

OBJECTIVE: Our goal was to determine the CT and US aspects of the fallopian tube in adnexal torsion. MATERIALS AND METHODS: The CT scans and US studies of 10 patients with surgically proven unilateral torsion of the adnexa were reviewed. RESULTS: On CT the fallopian tube on the involved side was identified in eight cases as an almost tubular or comma-shaped structure extending from the uterine cornua and covering partially the adnexal mass. This tube was significantly thickened and measured 20-40 mm. Hemorrhage (density > or = 50 HU on precontrast CT scans) was present in the tube in six patients. A heterogeneous contrast agent uptake was detected in the tube in five patients. An adnexal mass was visualized on the involved side in all patients, with hemorrhage in the mass in four patients. Peritoneal fluid and/or ileus were present in six patients. On US an echogenic structure that corresponded to the enlarged tube visualized on CT was detected in three cases and an adnexal mass in all cases. CONCLUSION: Thickening of the fallopian tube with hemorrhage could be detected by CT and is suggestive of torsion especially if associated with an adnexal mass.

Adnexal Diseases↗
PubMedDate not supplied

A simple index for representing the discrepancy between simulations of physiological pharmacokinetic models and experimental data.

The objective of this study was to develop an index that would provide a quantitative measure of the degree of discrepancy between simulations of physiologically based pharmacokinetic (PBPK) models and experimental data. The approach we developed involves the calculation of the root mean square of the error (representing the difference between the individual simulated and experimental values for each sampling point in a time course curve), and dividing it by the root mean square of the experimental values. The resulting numerical values of discrepancy measures for several data sets (each corresponding to an end point) obtained in a single experimental study are then combined on the basis of a weighting proportional to the number of data points contained in each data set. Such consolidated discrepancy indices obtained from several experiments (e.g., exposure scenarios, doses, routes, species) are averaged to get an overall discrepancy index, referred to as the PBPK index. This empirical index reflects the overall, weighted average percent difference between the a priori PBPK model simulations and experimental data. The proposed methodology is illustrated using previously published experimental and simulated data on dichloromethane pharmacokinetics in humans. The application of this kind of a "quantitative" method should help remove the ambiguity in communicating the degree of concordance or discrepancy between PBPK model simulations and experimental data.

Animals↗