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Biomedical subjects

S Haddad

Publications and source records attributed to S Haddad.

122 records · Page 7Linked to original sources

Stimulation of prepubertal, pubertal and adult rat testis with low-intensity pulsed ultrasound.

Testes of prepubertal, pubertal and adult Wistar rats were stimulated with low-intensity pulsed ultrasound for 20 min a day, for 7 days. No significant changes were found in the spermatogenic activity as well as in plasma LH and FSH levels following ultrasound treatment. The testicular androgenic activity, however, was significantly increased in prepubertal treated animals, in addition to a significant increase in seminal vesicle growth and secretory activity. In spite of normal androgenic levels, pubertal treated rats presented also an increase in the seminal vesicle secretory activity, thus suggesting a direct action of ultrasound on the gland.

Animals↗

Combination treatment of interferon alpha-2b and ribavirin in comparison to interferon monotherapy in treatment of chronic hepatitis C genotype 4 patients.

BACKGROUND AND AIM: Treatment of chronic hepatitis C patients, infected with genotype 4 with interferon-alpha yielded a limited response. Our aim was to compare the efficacy of interferon-alpha alone and in combination with ribavirin in chronic hepatitis C patients infected with genotype 4. PATIENTS: Fifty-two chronic hepatitis C patients (all males) infected with genotype 4, who had not received interferon, were randomized into 2 equal comparable groups. METHODS: Group I received interferon alpha-2b "Schering Plough" 3 MU, tiw combined with ribavirin (1000 mg/day). Group II received interferon alpha-2b alone in the same dose. Both groups were evaluated monthly, at the end of 24 weeks of treatment and 24 weeks later. Two patients were dropped from group I and one patient from group II. RESULTS: Biochemical response: at the end of treatment, a return to normal of ALT was obtained in 16/24 (66.7%) patients on combination therapy vs 8/25 (32%) patients on interferon alone (p = 0.0152). At the end of follow-up, a sustained response was achieved in 10/24 (41.7%) patients on combination therapy vs 4/25 (16%) patients on interferon (p = 0.0468). Virologic response: at the end of treatment, the rates of virological response were higher in the patients on combination therapy 9/24 (37.5%) than in those on interferon 4/25 (16%) (p = 0.0380). At the end of follow-up, loss of serum HCV RNA was reported in 5/24 (20.8%) patients on combination therapy vs 2/25 (8%) patients on interferon (p = 0.1916). Histologic response: mild histologic improvement was shown by a decrease in the inflammatory score, which was highest in patients in the combination group. CONCLUSIONS: In chronic hepatitis C patients infected with genotype 4, combination therapy with interferon-alpha and ribavirin was more effective than treatment with interferon monotherapy. At the end of the follow-up, about 50% of patients in both groups were still viraemic though their ALT remained normal.

Adult↗

[Indications for arteriography in penetrating wounds of the lower limbs].

One hundred arteriographies were performed in emergency in 87 patients with penetrating trauma of the lower limbs caused by high- or medium-velocity projectiles (bullet or shell fragment). Thirteen patients had bilateral wounds. In 79 cases, the arteriogram was abnormal and led to surgical exploration. In 76 cases, an arterial lesion was found and treated (positive predictive value = 76/79 = 96%). In three cases, no arterial lesion was detected (3 false-positive findings). Among the 21 patients with normal arteriograms, 10 had surgical exploration because of clinical suspicion. An arterial lesion was found in 2 cases (2 false-negative findings). In the other 11 cases, the clinical and Doppler sonographic observations were normal (negative predictive value = 19/21 = 90%). The sensitivity rate was 97%, specificity 86% and accuracy 95%. In 8 cases, arteriography led to modifying the surgical procedure. These results show that preoperative arteriography, performed as an emergent examination in hemodynamically stable patients, allows avoiding surgery in some cases, and modifying the procedure in others.

Adolescent↗

[Quality of health services in Africa : example of dystocia prenatal screening in Nioki (Zaire)].

Childbirth, though a common yet highly valued social event in Africa, is a major risk for the mother and child. During these last few decades, extension of health services has gained attention and their accessibility has improved. However, these health services remain inefficient because of their poor quality, especially for prenatal screening. This study with 59 cases and 177 controls was carried out in a rural district of Zaire. The objectives were to first assess the quality of the diagnosis of high risk pregnancy (HRP) and secondly to identify the main risk factors associated with complicated deliveries. The diagnosis of HRP has a low sensitivity (53%) yet a high specificity (95%). The diagnosis is based on postpartum hemorrhage and maternal height but does not consider primiparity or previous complicated deliveries. By improving the use of currently available information, a higher sensitivity (72%, could be obtained, identifying close to 3 out of 4 HRPs, but with a lower specificity (67%). The current diagnosis is conservative, partly because health personnel are reluctant to refer pregnant women, who could deliver normally, to the district hospital. Predictive criteria of complicated pregnancy are: primiparity, maternal height, previous difficult childbirth (dystocia), previous postpartum hemorrhage and lack of prenatal care. Prenatal screening should be a major component of safe motherhood programs. Our results show that in developing countries where emphasis is mainly put on the accessibility of health services, the quality of these services should become a priority. Quality is linked to efficiency, yet good quality gives a better image of services and improves compliance of the women.

Adolescent↗

[Endovascular treatment of arteriovenous vertebro-vertebral fistula].

Vertebral arteriovenous fistulae are relatively rare, with limited experience in most centers. We report our experience in the treatment of a vertebral arteriovenous fistula treated by interventional method. A review of the literature is made and the etiology, presentation and treatment of this unusual lesion are discussed. The endovascular occlusion is now the treatment of choice of vertebral fistulae.

Adolescent↗