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Biomedical subjects

S Fukuda

Publications and source records attributed to S Fukuda.

At least 721 records · Page 40Linked to original sources
PubMed1985

Potter's syndrome associated with renal agenesis or dysplasia. Morphological and biochemical study of the lung.

We report on four autopsy cases of Potter's syndrome associated with characteristic Potter's face, pulmonary hypoplasia, and renal agenesis or dysplasia. There were no pathologic differences in typical cases with bilateral renal agenesis and variant cases with renal dysplasia instead of renal agenesis. All cases showed bilateral pulmonary hypoplasias and immature lung microscopically. Hyaline membrane disease was found in three cases in spite of late gestation. In one case with renal dysplasia, disaturated phosphatidylcholine, a pulmonary surfactant phospholipid, was measured and found to be decreased in comparison with that in age-matched controls. This suggests that functionally immature lung may be one feature of Potter's syndrome that is similar to hyaline membrane disease.

Abnormalities, Multiple↗
PubMed1985

Metabolic conversion of alpha-keto valine to valine in patients with chronic renal failure.

Change in the metabolic conversion rate of alpha-keto valine to valine following oral administration of the analog of the essential amino acid (0.1 g/kgB.W.) is studied in six patients with chronic renal failure and five control subjects under low protein, low and normal energy intake diets. Diet I is composed of 105 kj (25 kcal)/kgB.W. energy and 0.6 g/kgB.W. protein, whereas Diet II is composed of 165 kj (40 kcal)/kgB.W. with the same amount of protein intake. As a result, an increase in plasma keto valine concentration is observed immediately after oral administration, followed by an increase in plasma valine concentration, implying that metabolic conversion of alpha-keto valine to valine occurs within a small amount of time. In addition, the conversion rate appears to be accelerated under Diet II. It is therefore suggested that reutilization of urea nitrogen with the ketoanalog under the low protein diet seems to be promoted under adequate energy intake.

Administration, Oral↗
PubMed1985

[A case of multiple carcinomas of the colon and rectum associated with ulcerative colitis].

The present paper describes a patient with four independent carcinomas associated with ulcerative colitis. Subtotal colectomy with lymph node dissection was done on June 28, 1978. The operative specimen revealed a carcinoma at the descending colon, two independent cancerous lesions and papillary polyps at the sigmoid colon and a scirrhous, flat elevated neoplasm at the rectum. These carcinomas were surrounded by lesions of various degrees of epithelial dysplasia, suggesting precancerous change. Carcinomas and precancerous lesions were stained for carcinoembryonic antigen (CEA) by the CEA peroxidase antiperoxidase method, which is considered to be useful to discriminate precancerous change from an inflamed mucous membrane.

Adenocarcinoma↗
PubMed1985

[Studies on ultrastructural changes in perivascular cells (F.G.P.) of small cerebral vessels at the initial stage after cold injury--chronological observations on F.G.P. within 24 hours].

As the potentiated cells in reaction to cerebral edema and damage, microglia, astrocytes and macrophages had been listed. Recent neuropathological study elucidated that most of cerebral macrophages were derived from blood leucocytes including monocytes. Several years ago, one of the authors reported the presence of histiocytic cells in perivascular space and named them as fluorescent granular perithelial (F.G.P.) cells from their morphological characteristics. The present paper is concerned with the response of the F.G.P. cells to the vasogenic edema induced with cold injury. The animals employed were Wistar male rats aged 3 months. At 2, 6, 10, and 24 hours after the cold injury, cerebral cortex was excised, and specimens were prepared for light and electron microscopical observations. As already reported, the F.G.P. cells included autofluorescent and PAS positive granules. The intracellular granules were rich in hydrolytic enzymes and lack in sudanophile substances. The F.G.P. cells were derived from leptomeningeal cells and acquired uptake capacity for exo- and endogenous substance after birth. In this paper, the F.G.P. cells locating in the boundary between cold injured and healthy regions were observed. At 2 to 10 hours after cold injury, the F.G.P. cells were vacuolated and swollen, and the electron opacity of them decreased moderately. Lipoidal substance appeared in the intracellular granules first at 2 hours and then increased, while the activity of acid phosphatase in them became low in corresponding with a time interval after the cold injury. At this period, occasionally the F.G.P. cells possessed a complicated boundary to astrocytes surrounding them. In general, such morphological changes were reversible and recovered partially around at 24 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1984

Pulmonary NAD+-linked 15-hydroxyprostaglandin dehydrogenase activity is decreased by cigarette smoking.

Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 13 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity, the key enzyme responsible for biological inactivation of prostaglandins, was found to decrease in lung but not in kidney or stomach following cigarette smoke exposure. The consequence of impaired pulmonary metabolism of prostaglandins and thromboxane may result in alteration of vascular homeostasis and subsequently lead to cardiovascular disorders commonly found in smokers.

Animals↗
PubMed1984

An unusual case of colonic leiomyosarcoma presenting with fever--significant uptake of radioactivity of gallium-67 in the tumor.

Leiomyosarcoma of the large intestine, excluding the rectum, is a rare lesion and only 58 cases have been previously reported. Significant uptake of radioactivity of gallium-67 to the tumor has not been reported and this report may be the first case. Although preoperative diagnosis is considered to be difficult, barium enema study and colonofiberscopy disclosed the findings suggesting extracolic growth of the tumor in our case, which are thought to be characteristics of nonepithelial tumors. Gallium-67 citrate scanning may be useful for confirming the diagnosis.

Adult↗
PubMed1984

A teratogenicity study of Phloxine B in ICR mice.

Pregnant Jcl:ICR mice were given Phloxine B in the diet at concentrations of 0, 1, 3 and 5% from the morning of day 6 through day 16 of gestation. The mice were killed on day 18 and foetuses were examined for external, visceral and skeletal anomalies. A significant decrease in body-weight gain was observed in all of the treated groups. Among the dams in the high-dose group, two maternal deaths, one abortion and a significant increase in liver weight were observed. A dose-related incidence of splitting of the cervical vertebral arches (nos 3-6) was noted in all of the treated groups, but this anomaly was not found in the controls. The total incidence of skeletal anomalies was also dose related and was significantly increased at the 3 and 5% dose levels. It was concluded that Phloxine B was teratogenic in mice at dietary levels of 3 and 5%, levels which resulted in maternal toxicity, and that a finding suggesting a teratogenic effect (split cervical arches) was also noted at the 1% dose level.

Animals↗
PubMed1984

Enterotoxigenicity of Staphylococcus intermedius strains isolated from dogs.

Dogs (n = 100) were examined for the presence of enterotoxigenic Staphylococcus intermedius. Enterotoxigenic strains were isolated from the nasal cavities of 43 (43.0%) out of 100 dogs. Of the 50 enterotoxigenic strains isolated, 23 (46.0%) produced enterotoxin A, 17 (34.0%) enterotoxins A and C, 8 (16.0%) enterotoxin C, and only two (4.0%) enterotoxins A and B. The amount of enterotoxin produced on semisolid brain heart infusion medium by the 17 enterotoxin A producing strains of S. intermedius was 10-160 ng per ml. Enterotoxin A production by S. intermedius strains was ony one tenth to one hundredth of that of S. aureus strains from staphylococcal food poisoning outbreaks.

Animals↗
PubMed1984

Thiopental potentiation of isolated rabbit pulmonary artery contractions with alpha receptor agonists.

The effects of thiopental sodium on the adrenergic neuroeffector junction were studied in isolated rabbit pulmonary arteries. Basal tension was not altered by thiopental (2 X 10(-5) and 10(-4) M) but was increased by high concentrations of thiopental (5 X 10(-4) M). Thiopental (10(-4) and 5 X 10(-4) M) potentiated contractions induced by transmural electrical stimulation. Contractile responses to exogenously applied low concentrations of norepinephrine (NE) were potentiated by thiopental (2 X 10(-5), 10(-4) and 5 X 10(-4) M), whereas those to high concentrations were not altered. In strips previously incubated in 1-[7,8-3H]-NE (10(-7) M), the release of [3H] induced by transmural stimulation (5 Hz) was not altered by thiopental (10(-4) and 5 X 10(-4) M). Potentiation by thiopental (10(-4) M) of the responses to transmural stimulation was not affected by prior application of cocaine or hydrocortisone. Contractions induced by alpha receptor agonists (phenylephrine and methoxamine) were potentiated by thiopental (10(-4) M), while those induced by acetylcholine were not altered. Contractile responses to potassium chloride were attenuated by thiopental (10(-4) M). Amobarbital sodium and pentobarbital sodium (10(-4) M, respectively) attenuated contractions induced by NE. It may be concluded that thiopental specifically increases the responsiveness of postsynaptic alpha receptors to NE.

Acetylcholine↗