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Biomedical subjects

R Schmidt

Publications and source records attributed to R Schmidt.

At least 793 records · Page 44Linked to original sources
PubMed1976

Cytogenetic studies in reproductive loss.

Cytogenetic studies were performed on 57 families with pregnancy wastage (eg, two or more spontaneous abortions or stillbirths). Chromosomal abnormalities were ascertained in 17 couples, through offspring with congenital malformations. Seven families had children with neural tube defects, and five families also had a previous child with Down syndrome. One mother had mosaic Turner syndrome; two additional mothers and one father had balanced chromosome translocations. These findings indicate that chromosome analyses should be performed on every couple with repeated miscarriages or malformed children, and subsequent pregnancies at risk should be monitored by amniocentesis.

Abortion, Spontaneous↗
PubMed1976

[Comparative examinations of stomach and duodenum with the use of Buscolysin and Cerucal].

The administration of buscolysin and cerucal in the pharmacoradiography of the stomach and the region of the small intestine was tested on every 50 patients. In these cases the differentiated range of action of the two preparations was shown. Buscolysin can be regarded as remedy of choice for the hypotonic duodenography, whereas cerucal is conspicuously suited for the functional diagnostics especially of the regions of antrum and bulb. By the aimed administration of the two preparations a complex functional diagnostics of stomach and duodenum is possible.

Ampulla of Vater↗
PubMed1976

Directed metal determination in pre- and post-natal stages of development of the islets of Langerhans by combined histochemical metal demonstration with electron probe X-ray microanalysis.

On the examples shown above it was possible to demonstrate that electron-X-ray microanalysis does not only present an important additional method for studying histochemical heavy metal reactions but can also be expected to provide, in combination with these, essential findings for the illustration of basic biological processes.

Animals↗
PubMed1976

[Cervical myelography with water-soluble contrast medium (Metrizamide). Technique and preliminary results (author's transl)].

Use of a water-soluble contrast medium for cervical spinal diagnosis has become possible with the introduction of Metrizamide (Amipaqque). Injection of contrast at the C.1/2 level by a lateral approach results in excellent visualisation of the cervical theca with previously unobtainable detail. This technique, which is so far not well known, allows a rapid examination and when used with the new, well tolerated contrast media provides optimal diagnostic results.

Cervical Vertebrae↗
PubMed1976

Monozygotic twins discordant for sex.

A pair of monozygotic, adolescent twins is discordant for sex. The phenotypic female twin has chromosome constitution of 46, XY/45, X. She displays many signs of Turner's syndrome, including typical facies, webbed neck, malformed left kidney, high plasma gonadotropins, and streak ovaries. However, her height is 154 cm which exceeds the height usually reported in Turner's syndrome. The male twin has a karyotype of 46, XY and normal sexual development. Only two other reports of pairs of monozygotic twins of opposite sex have been published.

Adolescent↗
PubMed1976

Topographic approach for analysis of palm crease variants.

As the variability and possible clinical significance of palm increase abnormalities receive greater attention, an accurate and objective method for evaluating the palm increase variants is required. A new method is described employing a topographic approach. A network of co-ordinates drawn on the palm prints enables an accurate and reproducible description to be made of unlimited numbers of variants of palm crease configurations. This method makes possible quantitative studies rather than merely qualitative descriptions of the palm crease patterns. To determine its usefulness, this method was employed in a comparative study of 100 individuals with Down's syndrome and 100 controls. Significantly higher total degree of transversality (T-DoT), as defined in this paper, was found in the Down's syndrome group. T-DoT may be a useful parameter in the evaluation of crease patterns of patients with congenital and genetic disorders.

Dermatoglyphics↗
PubMed1976

Effects of experimental hepatic artery embolization on hepatic function.

The hepatic artery was embolized with Gelfoam in 12 dogs to evaluate the effect of embolization on hepatic function. Liver function studies, including SGPT, alkaline phosphatase, BSP test, and bilirubin, were done serially over a 6 week period following the embolization. Eleven of the 12 embolized dogs survived the 6 week experimental period. Hepatic artery embolization caused some liver damage; however, recovery occurred by 6 weeks. These results suggest a possible therapeutic role for hepatic artery embolization in patients with massive hepatic bleeding or hemobilia who are not surgical candidates and who would require hepatic lobectomy or dearterialization to control the bleeding.

Animals↗
PubMed1976

Improved microscale assay for purine phosphoribosyltransferase activities.

We describe an improved and rapid filter-type assay for purine phosphoribosyltransferase activities. 14C-labeled purine bases are used as substrates, and the equipment includes a sampling manifold and glass-fiber filters coated with polyethyleneimine-cellulose. The method is especially suited for assay of a large number of samples, and may be useful for other enzyme activity measurements.

Adenine Phosphoribosyltransferase↗
PubMed1975

[Changes in the munber of 60-year old and older internal patients during a period of 10 years].

In 273 persons, of them 76 with ischaemic heart disease, 46 with non-coronary heart diseases (vitia, hypertension, chronic cor pulmonale, cardiomyopathy) and a control group of 115 healthy persons, during and after submaximal load under bicycle ergometry the ECG after work was recorded, in which case indication and contraindications of the WHO were taken into consideration. Especially investigated were the degree and the morphology of the ST-T-changes in differential-diagnostic respect in ischaemic heart disease and functional disturbances of the repolarisation. Apart from this the disturbances of rhythm and conduction system were analysed, which appeared under stress. The highest diagnostic evidence was under a load of 400-600 kmp/min and a pulse rate of 130-150/mim.

Adult↗
PubMed1975

Bioavailability studies with Digoxin-Sandoz and Lanoxin.

Various brands of digoxin tablets, and even different batches of one brand, may differ greatly in bioavailability. Digoxin-Sandoz tablets have been compared with Lanoxin manufactured between 1969 and 1972 and after May 1972. Comparisons were also made between and within batches of Digoxin-Sandoz tablets. Three separate cross-over studies were conducted involving a total of 20 volunteers. Digoxin-Sandoz tablets were shown to have a constant bioavailability and to produce plasma concentrations very similar to ""new'' Lanoxin. Storage for 2 years of one batch of Digoxin-Sandoz did not alter the bioavailability. Particle size was shown to influence bioavailability. Care should be exercised when plasma data alone are interpreted as an index of bioavailability. Measures of bioavailability based on plasma data obtained up to 6 h after administration differed from those based on cumulative urinary excretion data (in this study by a factor of about 2), which can lead to the belief that a difference in bioavailability is much greater than is actually the case. Data from cumulative urinary excretion, collected over a sufficiently long period of time, are likely to be the most reliable method for determining the bioavailability of a substance such as digoxin.

Adult↗
PubMed1975

Effect on cytotoxicity antibodies in potential transplant recipients of leucocyte-poor blood-transfusion.

In a controlled clinical trail, 40 uraemic patients received only leucocyte-poor blood (L.P.B.) while 30 uraemic controls received whole blood and ordinary packed red blood-cells (R.B.C.). Alloimmunisation by HL-A antibodies was found in 15% of the study group and 52% of the control group. Thus, L.P.B. was significantly less likely to produce alloimmunisation than ordinary whole blood or R.B.C. transfusion. Frozen R.B.C may produce even less alloimmunisation, but the advantages of L.P.B. include lower cost, prolonged storage, and ready availability in emergencies.

Adult↗