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Biomedical subjects

R Schmidt

Publications and source records attributed to R Schmidt.

At least 811 records · Page 45Linked to original sources
PubMed1975

[Behavior of the metabolism in gastric patients during a 4-day-long postoperative complete parenteral feeding with amino acids and a glucose-levulose-xylitol combination solution].

In a clinical study we tested the following parameters: free fatty acids, beta-hydroxybutyrate, acid-base-balance, lactate, bilirubin, uric-acid, fructose, xylitole, glucose in blood and urine. The tests were executed in 9 patients who were undergoing stomac operations. The cardio pulmonary system of all patients was normal, and there was a homeostasis in water and electrolytes preoperatively. In combination with the amino-acids we received a ratio of 1:1:1 for glucose, levulose and xylitole. Totally, the patients received 0.36 g per kg body weight and per hour of carbohydrates. Beta-hydroxybutyrate, aceto-acetat, and free fatty acids show normal values under conditions of parenteral nutrition as well as lactate, uric acid, and acid-base-balance. The ratio of the different carbohydrates in serum and urine prove that the infusion time and volume were extremely favourable. The loss of carbohydrates in urine was very low.

Acid-Base Equilibrium↗
PubMed1975

Minimising the risks of treating acute allograft rejection.

The risks of treating allograft rejection are primarily related to high-dose steroid therapy. To determine when the possible benefit of anti-rejection therapy might not justify the risks, we analysed 20 severe rejection (SAR) episodes for indices of reversibility. Prior renal function was similar in all patients. Ccr fell to 10 ml/min or less, but degree of renal dysfunction was not predictive of reversibility, nor were time since transplant, oliguro/anuria, proteinuria, or hypertension. The only consistent finding was that function began to improve in reversible rejection 3.8 +/- 1 days after beginning therapy. Our rejection treatment, based on this finding, is to use gram doses of IV prednisolone, up to three times in five to seven days. Among 41 patients with 45 grafts so treated, there was no fatality or gastrointestinal haemorrhage. Other complications (fistulae and/or infections) were related to total dose and frequency, to intensive therapy during severe renal dysfunction or to urinary leaks. Limitation of the period of high-dose steroid therapy was associated with reduced morbidity and mortality in renal allograft recipients.

Acute Disease↗
PubMed1975

[Morphologic studies on the effect of acrylnitrile in subchronic intoxication experiments in the white rat].

100 female and male white rats were treated with acrylnitrile using 4 various dosages. It was our practice to give orally acrylnitrile in physiological sodium chloride solution by probang, and the treatment was continued for 69 days from Monday to Friday in the week. After the treatment with acrylnitrile from the 70th day the animals were killed in intervals. Blood of orbital venous plexus was analysed by electrophoresis for determination of serum proteins, and organs were investigated histologically. It has been shown that of all organs the greatest alterations have been found in livers, kidneys and lungs. Taking by surprise our studies indicated that the application of 1/16 LD50 acrylnitrile dosage cause greater morphological damages in liver than those applications of higher concentrations in other groups.

Acrylates↗
PubMed1975

[Metabolic behavior in total parenteral nutrition during the postoperative phase].

In patients who had undergone gastric operation, total postoperative parenteral nutrition was effected using a combination of two infusion solutions having complementary constituents. 80 g L-amino acids and about 2,500 kcal in the form of a glucose-levulose-xylitol mixture together with electrolytes and trace elements were infused daily. Metabolic parameters, serum levels and the concentrations of the most important administered substances excreted in the urine were determined every day at the same time. The 1:1:1 glucose-levulose-xylitol ratio of the caloric carrier proved to be a favourable combination with respect to metabolic behaviour and the necessary daily supply of calories. The basic electrolyte requirement of the patients was to a large extent met by the quantities contained in the solutions.

Acid-Base Equilibrium↗