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Biomedical subjects

R Richter

Publications and source records attributed to R Richter.

At least 163 records · Page 9Linked to original sources
PubMed1984

Tumor-associated antigens in female genital tract cancers.

The immunologic reactivity of glycoprotein antigens extractable from individual, histologically different ovarian and uterine cancers was studied taking into account their relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), alpha-feto-protein (AFP), and alpha-1-antichymotrypsin. All studies were performed using specific immune sera against perchloric acid (PCA) extracts of ovarian mucinous cystadenocarcinoma (anti-PCA-CaOm) and cervical squamous cell carcinoma (anti-PCA-CaCx), and antisera against the reference antigens mentioned above. A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and often cross-reacting, but not identical with respective antigens of uterine body and cervical carcinomas; 4) an antigen reacting with anti-alpha-1-anti-chymotrypsin serum; and 5) an antigen reacting with anti-AFP serum.

Adenocarcinoma↗
PubMed1984

Tumor and serum CEA content in gynecologic neoplasms.

The relationship of serum carcinoembryonic antigen (CEA) levels to tumor tissue CEA content, and tumor weight in patients with different genital tract neoplasms was studied. Two-step extraction of tumor tissues was performed using perchloric acid and 3 M KCl. Sera and tissue extracts were assayed for CEA content by double-antibody radioimmunoassay. No clear correlation was found between serum CEA and tumor CEA contents, tumor weight, and histological structure. Our results showed, however, that high CEA concentrations in tumor tissue (10 micrograms/g or higher) were accompanied by elevated values in plasma.

Brenner Tumor↗
PubMed1983

Carcinoembryonic antigen in gynecologic cancers. Immunohistochemical localization and serum levels.

The presence of carcinoembryonic antigen (CEA)-dependent fluorescence was observed in almost 89% of female genital tract cancers irrespective of their histologic type. Anti-CEA serum was free of antibody to normal cross-reacting antigen. The high percentage of positive fluorescence tests did not correlate with the preoperative serum CEA levels. Double immunodiffusion tests showed different content of CEA and normal cross-reacting antigen in individual specimens of genital tract cancers.

Carcinoembryonic Antigen↗
PubMed1983

[Isolated tuberculosis of the sternum].

Isolated tuberculous foci of the sternum are rare. In a period of 26 years (1955 to 1981) we have treated ten sternal lesions surgically in our clinic. Eight of these were tuberculous. The clinical material (three females, five males) is described, including diagnostic and therapeutic details. The frequency, localisation, clinical features, diagnosis, treatment, prognosis and differential diagnosis of specific sternal infections are discussed and the relevant literature is reviewed.

Adult↗
PubMed1983

[Primary diaphyseal tuberculosis of the long bones].

Primary tuberculosis of the diaphysis of long bones is extremely rare. In the last 27 years (1955-1982) we observed one female patient with this infection in the shaft of the right femur and one male patient with symmetrical involvement of the tibiae in our Clinic. In both cases, the diagnosis was confirmed by histological examination of the lesions. The relevant literature is reviewed concerning the frequency, age incidence, localisation, clinical features, treatment, prognosis and differential diagnosis of tuberculosis of the diaphysis.

Adult↗
PubMed1983

Effect of substance P sequences on isolated neurons of Lymnaea stagnalis.

Effects of peptides and of acetylcholine (Ach) on electrical properties of nerve cells were compared using isolated neurons from brain of the freshwater mollusc, Lymnaea stagnalis. The peptides included certain partial sequences of Substance P (SP) and eledoisin (E). The essential C-terminal pentapeptide of eledoisin (E7-11) did not significantly influence the resting membrane potential (MP). SP hexapeptide (SP6-11) caused a dramatic depolarization. SP nonapeptide (SP3-11) had a qualitatively similar effect, but of less magnitude. Both SP6-11 and SP3-11 had a maximal effect on MP when used at a concentration of 10(-6) M. Ach also caused depolarization of the membrane, but recovery subsequent to wash-out was shorter after Ach than after peptide. Ach depolarization was blocked by d-tubocurarine chloride whereas SP6-11-induced depolarization was not antagonized. Unlike Ach, an eledoisin related peptide (EH) was found to decrease discharge rate of spontaneously discharging neurons, and whereas Ach increased membrane conductance, EH did not. These results would further suggest that Ach and these neurotropic peptides act via different mechanisms.

Acetylcholine↗
PubMed1983

Antigenic heterogeneity of human lung cancers.

Antigenic reactivity of 35 perchloric acid (PCA) extracts of different histologic human lung cancer tissues was studied--in comparison with the reactivity of the carcinoembryonic antigen (CEA), the nonspecific cross-reacting antigen (NCA), and alpha-1-antichymotrypsin--with the use of specific immune sera against PCA extracts of lung squamous cell carcinoma, and anti-CEA, anti-NCA, and anti-alpha-1-antichymotrypsin sera. The following antigenic systems were found in lung cancers: a) antigens specific for most squamous cell cancers and adenocarcinomas, which are undetectable in small cell cancers; b) NCA-type antigens; c) CEA-like antigens; and d) the antigen responsible for alpha-1-antichymotrypsin reactivity. A considerable antigenic heterogeneity among lung cancers indicates the necessity for precise histopathologic verification of individual lung cancer cases before commencement of immunologic studies and purification of antigens specific for lung cancers.

Adenocarcinoma↗
PubMed1983

[Differential diagnosis of varicose hemorrhage in pregnancy].

The problem of differential diagnosis of varicose bleeding is referred by means of a case of recurrent profuse vaginal bleeding during the 7th month of pregnancy. The bleeding occurred after cerclage and because of a suspected placenta praevia we did a cesarean section. This was followed by hysterectomy because of persisting bleeding. A vesico-vaginal-fistula occurred in consequence of maneuvers to stop bleeding at vaginal cuff. After recognizing and abolishing the reason of the bleeding we observed a normal healing. The closure of the fistula was successful.

Adult↗
PubMed1983

Effect of fusaric acid on the body temperature in spontaneously hypertensive and normotensive rats.

The effect of fusaric acid (FA) on the body temperature of age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY) was investigated at an ambient temperature of 4 degrees C. During a 7 h period of cold exposure the body temperature decreased by 6.5 degrees C in WKY (p less than 0.01) and by 5.4 degrees C in SR (p less than 0.05) after administration of 100 mg/kg FA, with the effects occurring faster in WKY. At 50 mg/kg the effect was lower. Naloxone completely abolished the temperature effect of FA in both rat strains. The naloxone antagonism may point to an opiate involvement in the thermoregulation after FA. A possible contribution of vasopressin and tetrahydroisoquinoline alkaloids to the maintenance of body temperature is also discussed.

Animals↗