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Biomedical subjects

R Richter

Publications and source records attributed to R Richter.

At least 145 records · Page 8Linked to original sources
PubMed1986

Severe pulmonary arterial stenoses in Conradi-Hünermann disease.

A 5-month-old male infant with chondrodystrophia punctata type Conradi-Hünermann showed electrocardiographically an increasing right ventricular hypertrophy. Echocardiographically an enormous enlarged right ventricle with signs of supra-systemic pressure was found. No other intracardiac defects could be seen. Angiography showed severe peripheral pulmonary arterial stenoses of both main arteries. Balloon-dilatation or surgical intervention was supposed to have no beneficial effect. At the age of 6 months the patient died.

Angiography↗
PubMed1986

Immunological reactivity of mucinous and serous ovarian adenocarcinomas.

Comparison of immunological reactivity of glycoprotein antigens extracted from individual cases of mucinous and serous ovarian adenocarcinomas was performed taking into account the immunological relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), alpha-1-antichymotrypsin, and alpha-1-acid glycoprotein. In all immunological tests, the specific immune sera against perchloric acid extracts of ovarian mucinous and serous cystadenocarcinomas and antisera against the reference antigens mentioned above were used. It was established that: 1) ovarian mucinous and serous adenocarcinomas are immunologically different and possess various tumor-associated antigens, 2) ovarian mucinous adenocarcinomas contain considerable amounts of CEA and NCA, whereas serous type neoplasms show negligible amounts or lack of these antigens; and 3) in both types of tumors, alpha-1-antichymotrypsin and alpha-1-acid glycoprotein activities are found. Immunological data indicate that ovarian mucinous and serous adenocarcinomas derive from separate lineages of epithelium.

Adenocarcinoma, Mucinous↗
PubMed1986

Distribution of surface nonspecific cross-reacting antigen and influence of proteolytic enzymes on this antigen in myeloid cell series.

Discontinuous density-gradient centrifugation was used to separate myeloid cells of different myelocytic leukemias [acute myelocytic leukemia (AML), chronic granulocytic leukemia (CGL), and chronic granulocytic leukemia in blast crisis (CGL-BC)] into fractions containing granulocytes in individual stages of maturation. The distribution of surface nonspecific cross reacting antigen (sNCA), and cytoplasmic NCA (cNCA) in each cell fraction was estimated by immunofluorescence (IF), and the influence of proteolytic enzymes and neuraminidase on sNCA presence was analyzed. It was found that the percentage of sNCA- and cNCA-positive cells increased in more mature granulocyte fractions; only in the morphologically oldest granulocytes did the number of sNCA-positive cells decrease, probably as a result of the rise of NCA secretion into body fluids; proteolytic enzymes caused an increasing number of sNCA-expressing cells; and neuraminidase treatment usually reduced the percentage of sNCA-positive cells.

Antigens, Neoplasm↗
PubMed1986

The membrane potential of pig aortic endothelial cells.

Membrane potential and cell number of endothelial cells from pig aorta (line BSEz-3) were determined in vitro in different phases of growth. We found different membrane potentials for mononuclear (-8.6 mV) and multinuclear (-21.9 mV) endothelial cells. In both cases the maximum membrane potential occurred on the 6th day after seeding (during the exponential growth phase). The fraction of multinuclear endothelial cells was about 2.1% in the total culture. The membrane potentials of pig aortic endothelial cells are similar to our earlier values obtained from calf aortic endothelial cells.

Animals↗
PubMed1985

Non-specific cross-reacting antigen (NCA) in individual maturation stages of myelocytic cell series.

The distribution and localization of NCA and carcinoembryonic antigen CEA in cells of different types of myelogenous leukaemias (acute myelogenous leukaemia - AML; chronic granulocytic leukaemia - CGL; CGL in myeloblastic crisis - CGL-BC) was studied using the immunofluorescence test. Discontinuous density-gradient centrifugation was used to separate myeloid cells into fractions containing granulocytes in individual stages of maturation. Serum NCA and CEA levels were estimated in parallel. It was established that: (a) AML blasts without maturation (MO type) and monoblasts did not synthesize NCA; (b) individual blasts of AML with features of maturation (M1, M2 types) and some myeloblasts of CGL-BC exhibited a limited ability to express cytoplasmic NCA; (c) the number of NCA-containing cells increased in the more mature granulocyte fractions isolated on Ficoll-Hypaque density-gradients; (d) myelocytic NCA is immunologically related to NCA isolated from lung tissue and (e) CEA is undetectable in the myelocytic cell series.

Antigens, Neoplasm↗
PubMed1985

[Detection of intrauterine growth retardation within the scope of routine prenatal care].

In a retrospectively reviewed series of 84 small for gestational age newborn (below less than P10), 45 were identified to be growth-retarded by routine prenatal care. Among 58 babies below less than P5, the diagnosis of IUGR was made in 62 per cent. Results of ultrasound measurements were below normal range in 55 per cent. Symphyseal-fundal distance was abnormal in 36 per cent. Both ultrasound and SF distance yielded abnormal results in 18 pregnancies, whereas normal results were seen in 10 women. In 8 pregnancies, either SF distance or ultrasound examination indicated IUGR. However, in 28 out of 39 patients, in which IUGR was not recognised during pregnancy, clinical findings and/or obstetrical history were positive.

Asphyxia Neonatorum↗
PubMed1985

Cervical carcinoma antigen, carcinoembryonic antigen (CEA), and nonspecific cross-reacting antigen (NCA) in appraisal of uterine cervix smears.

The distribution of cervical carcinoma antigens (AgCaCx), CEA, and NCA in different pathologic states of the uterine cervix was studied in cytologic smears by an immunofluorescence method (IF) using specific immune sera against perchloric acid (PCA) extract of cervical squamous cell carcinoma, anti-CEA, and anti-NCA. After excluding cross-reactivity with CEA and NCA, the presence of AgCaCx was demonstrated in the majority of cervical carcinomas, severe dysplasias, and only in one-fourth of squamous metaplasias, especially when accompanied by mild or moderate dysplasias. The intensity and percentage of IF-positive cells varied from case to case. The preparations of uterine cervix without pathologic changes usually were negative. Similar results were obtained with anti-CEA serum. NCA was present in the majority of smears independent of histologic diagnosis. The most intense fluorescence was observed in upper layers of the epithelium. NCA could be a differentiation antigen of stratified squamous cell epithelium.

Adenocarcinoma↗