Biomedical subjects
Publications and source records attributed to R J Coskey.
One hundred and twenty-one children with plantar warts were treated with a topical preparation containing salicylic acid, 30%; podophyllin, 5%; and cantharidin, 1%. One hundred patients or their families were reached 6 months to 1 year later. This treatment was effective in 81 cases.
Perioral dermatitis is an eruption that has a characteristic perioral localization. It usually responds rapidly to systemic tetracycline and low-potency topical corticosteroids. In a study of eighty-seven patients it was found that systemic erythromycin is also effective and that in some instances topical antibiotics combined with 1 per cent hydrocortisone may be effective.
Three cases of contact dermatitis caused by an ethanolamine antihistamine, diphenhydramine hydrochloride (Benadryl), are described. Patients who develop contact dermatitis from it should avoid its oral or parenteral administration because they may develop a localized or generalized flare of dermatitis. Dimenhydrinate (Dramamine), clemastine fumarate (Tavist), carbinoxamine maleate (Clistin-D), and doxylamine succinate (Decapryn) are also ethanolamine antihistamines. Since they may cross-react with diphenhydramine hydrochloride, they should be avoided in sensitive patients.
In this paper I have reviewed the literature on dermatologic therapy from December, 1981, through November, 1982. This information was presented to a forum at the 41st Annual Meeting of the American Academy of Dermatology in New Orleans in December, 1982. Readers should review the original article in toto before attempting any new, experimental, or controversial therapy summarized.
A 4-month-old infant with a congenital, darkly pigmented, macular lesion involving the subungual and periungual areas of the right ring finger is described. The lesion was excised when the infant was 6 months old in order to rule out a congenital pigmented nevus as well as a congenital acrolentiginous melanoma. Histopathologic examination revealed a compound nevus. Nevi in this location are very rare in Caucasians at any age and should probably be excised to rule out malignant melanoma.
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Two patients in whom tumors developed in organoid nevi are reported. The first patient, a 50-year-old man, had a trichilemmoma arising from an organoid nevus on the scalp. The second patient, a 68-year-old woman, had a basal cell epithelioma, sebaceous epithelioma, syringocystadenoma papilliferum, and a trichilemmoma arising from an organoid nevus on the face.
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A father and his son were seen because of multiple wartlike lesions on their fingers and palms. On histologic examination, these lesions showed changes compatible with vascular fibromas, myxoid fibromas, and, in a few instances, verruca vulgaris. We are not aware of reports of similar cases in the dermatologic literature.
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Two cases of recurring digital fibrous tumor of childhood are reported. Both patients were infants who had lesions on the toes or fingers. In one case the lesions recurred after surgical excision and in the other the lesions started to resolve without therapy. The histologic sections of tissue showed the intracytoplasmic inclusion bodies typical of this condition.
Of six cases of granuloma annulare of the face, three cases were not associated with lesions on the extremities or trunk. Histologic examination exhibited typical features of granuloma annulare. One patient's lesion was a recurrent solitary subcutaneous nodule.