Biomedical subjects
Publications and source records attributed to R J Coskey.
This article reviews some therapeutic results reported in the English-language literature during 1993. Readers should review the original article in full before attempting any experimental or controversial therapy.
This article reviews therapeutic studies reported in the English-language literature during 1992. Readers should review the original article in full before attempting any experimental or controversial therapy.
This article reviews therapeutic advances reported in the English-language literature during 1991. Readers should review the original article in full before attempting any experimental or controversial therapy.
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This article reviews significant therapeutic advances that have been reported in the English-language literature during 1990. Readers should review the original article in full before attempting any new experimental or controversial therapy.
In this article I have reviewed the significant therapeutic advances that have been reported in the English-language literature from December 1987 to December 1988. Clinicians should read the original articles in toto before attempting any new experimental or controversial therapy.
Histiocytosis X (HX) is a rare disorder of histiocytic proliferation characterized by a broad spectrum of clinicopathologic disease. An unusual case of Letterer-Siwe disease (LSD) or subacute disseminated HX in a 71-year-old woman is presented. The patient had a 3-year history of splenomegaly before skin lesions developed. She presented to our clinic at 1.5 years later and the diagnosis of HX was made by skin biopsy. Topical nitrogen mustard (NM) therapy resulted in complete clearing of cutaneous lesions. Her condition was stable over the next 10 months. However, she subsequently suffered a rapid and fatal dissemination of her disease. Systemic treatment with prednisone, vinblastine sulphate, and suppressin A (SA) (a calf thymus derived hormone preparation that specifically induces suppressor T-cells) was ineffective. Characteristic histopathologic, immunohistochemical, and electron microscopic findings of HX are illustrated. A review of the adult cases of LSD and treatment options for HX are presented and discussed.
In this article I review significant therapeutic advances reported in the English literature from December 1986 to December 1987. Readers should review the original articles in toto before attempting any new experimental or controversial therapy summarized.
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I have reviewed the significant therapeutic changes reported in the English literature between December 1985 and December 1986. Readers should review the original articles in toto before attempting any new experimental or controversial therapy summarized.
Sixty patients with impetigo were seen in a private practice. Cultures of specimens from all but one patient grew coagulase-positive Staphylococcus aureus. The culture of one patient grew pure group A beta-hemolytic streptococcus. The cultures of six patients were mixed, having streptococci and S. aureus. In all but one instance the staphylococci were resistant to penicillin and ampicillin. We recommend that all centers treating patients with superficial skin infections have a method of screening or spot checking their patient population to determine antibiotic sensitivities and the frequency and distribution of these infections. Then, if bacteriologic and antibiotic sensitivity studies mandate, a switch in antibiotics should be contemplated.
We report the case of a patient who had a lesion on the back that clinically resembled a basal cell carcinoma, but histologically showed changes of a basal cell carcinoma and a nodular malignant melanoma. We also review the literature on the association of basal cell carcinomas with other tumors.
A patient with recurrent chalazia is described. This patient also had acne rosacea. The clinical and histologic characteristics of chalazia are described. In addition, therapy for chalazia is presented, with emphasis being given to conservative therapy.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.