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Biomedical subjects

R J Barr

Publications and source records attributed to R J Barr.

At least 127 records · Page 7Linked to original sources
PubMed1980

Bizarre cutaneous neurofibromas.

Bizarre cutaneous neurofibroma is an uncommon benign neoplasm. Microscopically, it is usually characterized by stellate and polyhedral cells embedded in a myxoid stroma, and less commonly by solid sheets of epithelioid cells. Cellular pleomorphism and mitotic figures are regular features and have resulted in erroneous diagnosis of malignancy. The mucinous material has the staining characteristics of a sulfated mucosubstance, probably chondroitin sulfate B. Terms previously applied to this lesion include nerve sheath myxoma. Pacinian neurofibroma, myxoid neurofibroma, and neurotheceoma.

Adolescent↗
PubMed1980

Intraepithelial elastic fibers and intracytoplasmic glycogen: diagnostic aids in differentiating keratoacanthoma from squamous cell carcinoma.

A significant statistical difference was found between the incidence of intraepithelial elastic fibers in keratoacanthoma and squamous cell carcinoma arising in actinic keratosis (P < 0.001). There was no significant difference when keratoacanthoma was compared to adenoid squamous cell carcinoma (P = 0.13) and de novo squamous cell carcinoma (P = 0.73). However, in keratoacanthoma intraepithelial elastic fibers were found in areas of pseudoepitheliomatous hyperplasia and in the central keratin plug, as well as in areas of infiltrating, peripheral keratinocytes. In adenoid squamous cell carcinoma and de novo squamous cell carcinoma, the intraepithelial elastic fibers were found only in areas of atypical epithelial cells at the margin of the neoplasm. Intracytoplasmic glycogen was found to be statistically more abundant in keratoacanthoma than in squamous cell carcinoma arising in actinic keratosis (P < 0.001), adenoid squamous cell carcinoma (P < 0.001), and in de novo squamous cell carcinoma (P < 0.001)

Carcinoma, Squamous Cell↗
PubMed1980

Verruciform xanthoma of the skin.

Verruciform xanthoma is an unusual lesion characterized by verrucous epithelial proliferation accompanied by a prominent replacement of the dermal papillae with large numbers of foamy histiocytes. Cases have been previously reported only as occurring in the oral cavity or, more rarely, on the vulva. A 16-year-old girl developed a verruciform xanthoma of the skin. The lesion appeared to arise within a large epithelia nevus involving the left inner thigh and inguinal area. This association supports the concept that verruciform xanthoma is a rare inflammatory reaction pattern that may be seen in a variety of squamous epithelial lesions characterized by verrucous hyperplasia.

Adolescent↗
PubMed1980

Immunoperoxidase staining of cytoplasmic immunoglobulins. A diagnostic aid in distinguishing cutaneous reactive lymphoid hyperplasia from malignant lymphoma.

A method for staining cytoplasmic immunoglobulins utilizing an immunoperoxidase technic on paraffin-embedded tissue was used to examine two cutaneous lesions. On routine hematoxylin-eosin staining, one lesion exhibited what appeared to be a mixed population of mature cell types and was therefore interpreted as reactive lymphoid hyperplasia, whereas the other lesion showed a uniform population of immature cells and was interpreted as a malignant lymphoma. Immunoperoxidase staining supported these interpretations since the reactive lesion showed polyclonal IgG lambda and kappa staining, and the malignant lymphoma monoclonal staining with IgG lambda. In selected material, immunoperoxidase staining can distinguish a truly mixed population of cell types (probably benign) from a monoclonal population of cells exhibiting either uniform or mixed morphologic configurations associated with B lymphocyte transformation (probably malignant).

Aged↗
PubMed1979

Transient neonatal pustular melanosis.

A Mexican-American boy presented at birth with an extensive eruption consisting of 0.5 to 1.0 cm hyperpigmented macules with a distinct peripheral scale involving primarily the forearms, abdomen and lower back (Fig. 1). Rare intact vesicopustules were also identified. There was an unremarkable prenatal history, and the infant was a product of a normal vaginal delivery. With the exception of the skin lesions and moderate hepatosplenomegaly, the physical examination was normal. Gram stains of the pustules showed numerous neutrophils but no bacteria. Bacterial cultures, of the skin and blood, TORCH screen (toxoplasmosis, rubella, cytomegalic virus, and herpes virus) and a VDRL were negative. On the second day of life, the patient developed several pustules with surrounding erythema consistent with erythema toxicum neonatorum. Wright-stained smears of these lesions showed abundant eosinophils. Hepatosplenomegaly resolved by the third day of life and at the time of discharge only hyperpigmented macules persisted. Follow-up visit six weeks later showed no evidence of skin lesions.

Erythema↗
PubMed1979

Fibrous hamartoma of infancy.

Fibrous hamartoma of infancy is a type of juvenile fibromatosis which is either present at birth or develops before two years of age. If one is not familiar with this histological pattern, it could be mistaken for a malignant mesenchymal neoplasm. We describe the characteristic clinical and microscopic features.

Diagnosis, Differential↗
PubMed1979

Syringometaplasia: mucinous and squamous variants.

The eccrine sweat ducts are normally lined by cuboidal epithelial cells which may rarely undergo metaplasia, i.e. syringometaplasia. Two lesions were observed in which eccrine sweat ducts displayed the mucinous and squamous variants of syringometaplasia. The first lesion clinically and histologically appeared to be a plantar wart. Microscopically, it consisted of a central invagination surrounded by marked epidermal acanthosis and hyperkeratosis. The invagination was lined by keratinocytes admixed with mucin-filled goblet cells. The mucin was positive by the Alcian blue (pH 2.5) and mucicarmine stains. Numerous eccrine sweat ducts led into the invagination and were focally lined by the mucin-laden cells. Recognition of mucinous syringometaplasia is important since it may be confused with primary or metastatic adenocarcinoma of the skin. The second lesion occurred on the outer ear and was clinically believed to be chondrodermatitis nodularis helicis. Microscopically, there were many islands of atypical squamous cells within the papillary and reticular dermis. These epithelial islands represented squamous syringometaplasia since many contained central lumina with eosinophilic cuticles and blended with normal ductal structures. It is important not to confuse this metaplastic change with invasive squamous cell carcinoma. Squamous syringometaplasia may be analogous to necrotizing sialometaplasia, a recently described phenomenon which occurs in minor salivary glands.

Adenocarcinoma↗
PubMed1979

Granular cell basal cell carcinoma. A distinct histopathologic entity.

In two cases of basal cell carcinoma with prominent granular cell features, light microscopic examination showed a tumor with the general configuration of a nodular basal cell carcinoma. Focally, there were masses of cells with eosinophilic, granular cytoplasm and large cytoplasmic inclusions, strongly suggestive of granular cell myoblastoma. Ultrastructural observations in one case showed numerous lysosome-like organelles that were similar to those described for granular cell myoblastoma, but were identical to those described for the granular cell variant of ameloblastoma, a tumor that frequently resembles basal cell carcinoma. Additional features included tonofilaments and desmosomes, both of which support an epithelial origin for the granular cells in this rare variant of basal cell carcinoma.

Aged↗
PubMed1979

Verrucous ulcerative skin lesions in sarcoidosis. An unusual clinical presentation.

A twenty-seven year old man with a two year history of sarcoidosis and systemic manifestations of this disease along with verrucous ulcerative skin lesions is presented. Biopsy specimens of the cutaneous lesions showed typical noncaseating granulomas as well as necrotizing granulomatous inflammation. After other possible etiologies were excluded, prednisone therapy was instituted with prompt resolution of the skin lesions, leaving atrophic scars.

Adult↗
PubMed1978

Biopsy of the nail area.

It is as simple to biopsy around the nail as it is at any other site, and there are multiple lesions that deserve biopsy. Biopsy of the nail bed or nail matrix is avoided unless there is possible malignant change. Biopsy sites in the nail bed usually heal satisfactorily, but biopsy of the matrix is more likely to produce permanent deformity.

Biopsy↗
PubMed1978

Intravascular papillary endothelial hyperplasia. A benign lesion mimicking angiosarcoma.

Observations were made of three cases of intravascular papillary endothelial hyperplasia (IPEH). Lesions of IPEH usually occur on the head and neck area as a subcutaneous red or blue nodule. This papillary proliferation of endothelial and stromal tissue occurs de novo in organizing venous thrombi or in preexisting hemangiomas or phlebectasias. An adequate understanding of this benign vascular disorder is important, since the lesion may be clinically and histologically mistaken for low grade angiosarcoma.

Adult↗