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Biomedical subjects

R J Barr

Publications and source records attributed to R J Barr.

142 records · Page 8Linked to original sources
PubMed1977

Rapid method for Tzanck preparations.

Use of the Paragon Multiple Stain for Frozen Sections (PMS) for Tzanck preparations of herpetic lesions has several distinct advantages over procedures previously described; the method is rapid, simple, inexpensive, and results in hematoxylin-eosin-like staining. This enables a diagnosis to be made from a single, affected cell.

Cytodiagnosis↗
PubMed1977

Nevi in leprosy.

Explore the source record for details and available documents.

Adult↗
PubMed1977

Ultrastructure of atypical fibroxanthoma.

Electron microscopic examination of an atypical fibroxanthoma (AFX) confirmed the fibrohistiocytic nature of this lesion. Ultrastructural evidence suggested a transition from fibroblasts to large giant cells with intermediate forms exhibiting features of both. A comparison of AFX ultrastructural features to those of other similar neoplasms suggested a possible relationship to malignant fibrous histiocytoma. As diagnosed by light microscopy, AFX probably represents a spectrum of neoplasms; this concept is discussed. It is urged, when possible, that electron microscopy be performed on lesions diagnosed as atypical fibroxanthoma since ultrastructure studies represent the most valid basis on which a correct diagnosis can be made.

Aged↗
PubMed1977

Malignant neoplasms metastatic to gingivae.

Malignant neoplasms metastatic to the gingivae are rare. Our review of the literature revealed only eight acceptable examples. We are reporting two additional cases. One patient was a 58-year-old man with an adenocarcinoma of the lung which metastasized bilaterally to the maxillary gingiva. The second patient was a 27-year-old man with a synovial sarcoma which metastasized to multiple sites in the maxillary and mandibular gingiva. Clinically, gingival metastatic lesions are most often confused with hemangioma, pyogenic granuloma, giant-cell granuloma, and pepripheral fibroma. They usually occur late in the course of the disease and are associated with metastatic deposits in many other organs and tissues. Death usually occurs in a few weeks or months after discovery of the gingival metastasis.

Adenocarcinoma↗
PubMed1977

Papulosquamous eruptions: usefulness of biopsy in establishing diagnosis.

Papulosquamous dermatoses are caused by a variety of etiologic agents. T. rubrum in particular can produce clinicopathologic changes which mimic a spectrum of disorders. Of these, some are papulosquamos in character. Whenever patients are seen with atypical papulosquamous dermatoses, the clinical differential diagnosis should always include dermatophytosis caused by T. rubrum. If skin scrapings for direct microscopic examination and culture studies are negative, a biopsy should be seriously considered as the best procedure to aid in making the correct diagnosis. Periodically, tissue diagnoses of fungal disease are made by dermatopathologists when the problem has not even been suspected by the clinician. Clinicians and pathologists should maintain a high index of suspicion for the disease spectrum which T. rubrum can cause in the human host. T. rubrum represents a great mimicker of cutaneous diseases similar to eruptions caused by Treponema pallidum and drugs. Information T. rubrum and methods have been reported.

Adult↗
PubMed1977

Hemangiopericytoma of the parotid gland with a review of the literature.

Hemangiopericytoma, a rare vascular tumor characterized by pericytes, has been confused with benign lesions. The tumor cannot be identified clinically and requires histopathologic examination. Although the five year survival rate is good, the 10 year survival rate is poor for tumors in the head and neck region. Aggressive treatment with wide surgical margins appears warranted. Surgery in combination with radiotherapy has improved the poor prognosis. A case of hemangiopericytoma of the parotid gland, the eighth known in the surgical literature, is presented which illustrates the difficulty in the diagnosis and treatment of this lesion.

Hemangiopericytoma↗
PubMed1976

Ultrastructure of spindle cell squamous carcinoma.

A 63-year-old white male presented with a nine-month history of a nontender ulcerated lesion on his ear. Light microscopy demonstrated a moderately well circumscribed lesion in the dermis which abutted upon epidermis. There was no evidence of continuity between the tumor and overlying epithelium. The tumor was very cellular with an admixture of cells - spindle, polyhedral and bizarre giant cells. Mitotoc figures were abundant and frequently abnormal. We interpreted this lesion to have the clinical and pathologic features of an atypical fibroxanthoma (AFX). Ultrastructure, however, showed abundant tonofilaments and desmosomes indicative of an epithelial origin and therefore most consistent with a spindle cell squamous carcinoma (SCSC). It is urged that, when possible, electron microscopy be performed on problematic cases diagnosed either as an AFX or spindle cell squamous carcinoma since it is the most valid basis on which a correct diagnosis can be made.

Carcinoma, Squamous Cell↗
PubMed1975

Adenosquamous carcinoma of the liver.

A rare case of adenosquamous carcinoma of the liver is reported. An 85-year-old white man presented with a 6-month history of weight loss and an enlarged liver. A biopsy demonstrated a squamous cell carcinoma which was presumed to be metastatic with an occult primary. At autopsy, the liver was partially replaced by a focally cystic tumor. Histologically, the neoplasm demonstrated both malignant squamous and glandular contradistinctionmponents as well as foci of transition between the two. This is in co to the 5 previous reported cases of primary hepatic squamous cell carcinomas or tumors containing a squamous component. It is suggested that this neoplasm arose from malignant transformation of squamous metaplasia in a pre-existing cholangiocarcinoma.

Adenocarcinoma↗
PubMedDate not supplied

Does hydroxyethyl starch cause lichen planus? Lichen planus in a long-time routine blood donor never exposed to hydroxyethyl starch.

A case of lichen planus attributed to exposure to hydroxyethyl starch has been reported previously. In this report, a case of lichen planus in a healthy blood donor never exposed to hydroxyethyl starch is presented, the statistical incidence of lichen planus in healthy leukapheresis donors is approximated, and a description of the Koebner phenomenon, which could falsely lead to incorrect conclusions regarding cause and effect in this disease, is discussed.

Adult↗
PubMedDate not supplied

A rapid immunoperoxidase technique to distinguish herpetic types.

The United States is experiencing an epidemic of herpetic infections. Rapid specific diagnosis of herpes simplex types and herpes zoster is important epidemiologically and also for individual cases since treatment as well as prognosis for recurrence or dissemination varies with virus type. We report a rapid test for the diagnosis and differentiation of these infections. This test uses scrapings from viral vesicles. It employs standard immunoperoxidase techniques and takes 2 hours to perform at 37C. Smears from 13 patients with clinical and/or culture confirmation of viral type were tested. Eleven of eleven who had fresh smears (vesicles present less than 5 days) had positive staining for the viral type expected clinically. Two patients with vesicles 5 days or older showed nonspecific staining.

Diagnosis, Differential↗