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Biomedical subjects

R J Barr

Publications and source records attributed to R J Barr.

At least 109 records · Page 6Linked to original sources
PubMed1984

Delayed skin test reaction to injectable collagen implant (Zyderm). The histopathologic comparative study.

Ten cases of persistent positive test site responses to enzyme-digested purified bovine collagen solution (EPC; Zyderm Collagen Implant) were reviewed. Specimens were stained with hematoxylin and eosin, Gomori's trichrome, colloidal iron, elastic van Gieson, Snook 's reticulum, and polarized light. These granulomatous-like reactions were compared with cases of granuloma annulare, hypertrophic scarring, keloids, and rheumatoid nodules. These studies make it possible to differentiate a normal EPC implant from normal reticular dermis. The granulomatous reaction around the EPC implant can be differentiated from granuloma annulare, scars and keloids, and rheumatoid nodules. It is our conclusion that the granulomatous material is probably a combination of EPC and small amounts of altered human collagen.

Adult↗
PubMed1984

Cyclosporine and murine allergic contact dermatitis.

Cyclosporine is a new antilymphocytic, immunosuppressive agent currently being used primarily in experimental and human organ transplantation. The current study evaluated the effect of systemically administered cyclosporine on a cutaneous T-cell-mediated disorder by using the murine model of allergic contact dermatitis to dinitrofluorobenzene. Cyclosporine was found to significantly inhibit the ear swelling response, whether the drug was given during the early sensitization period or at the time of antigenic challenge to fully sensitized mice. This suppressive effect was reversible when mice were rechallenged with dinitrofluorobenzene 96 hours after the first challenge. Cyclosporine was not effective if given to sensitized animals as late as six hours after challenge. Lastly, the observed inhibition of the ear swelling response to cyclosporine closely paralleled a diminished degree of inflammation seen histopathologically.

Animals↗
PubMed1984

Filaggrin distribution in keratoacanthomas and squamous cell carcinoma.

The cellular distribution of filaggrin, a histidine-rich protein present in the granular and horny layers of normal epidermis, was investigated in 27 human keratoacanthomas and squamous cell carcinomas of the skin using an indirect immunohistochemical procedure with rabbit antimouse filaggrin immunoglobulin. Using the same working dilution of the primary antibody, normal epidermis, as well as all keratoacanthomas, exhibited a positive immunoperoxidase or immunofluorescence stain in the granular and horny layers; whereas, all squamous cell carcinomas, except one, were negative. With higher concentrations of primary antibody, two additional carcinomas showed a weak, positive staining. We suggest that the absence of filaggrin in squamous carcinomas could be of use in the differential diagnosis of cutaneous tumors.

Carcinoma, Squamous Cell↗
PubMed1983

Mixed carcinoma in situ: an immunohistochemical study.

A case of mixed carcinoma in situ, of the skin, is presented. The lesion, located on the right temple of a 71-year-old man, showed histologic features of Bowen's disease and extramammary Paget's disease. This case suggests that Bowen's disease and extramammary Paget's disease may arise from pluripotential adnexal epithelium capable of keratinocytic and glandular differentiation. Utilization of the peroxidase-antiperoxidase technique for demonstrating carcino-embryonic antigen was performed in order to identify the component interpreted as extramammary Paget's disease. This procedure is apparently more sensitive than the commonly employed histochemical stains for demonstrating glandular differentiation.

Adenocarcinoma↗
PubMed1982

Microcystic adnexal carcinoma: a distinct clinicopathologic entity.

Microcystic adnexal carcinoma is an unusual locally aggressive neoplasm that is important to recognize since it may be confused with benign adnexal neoplasms, particularly desmoplastic trichoepithelioma, trichoadenoma, and syringoma. Six cases are described all of which displayed benign histological features on initial biopsy. Most often these neoplasms presented as solitary flesh-colored indurated plaques on the upper lip. All patients were white, five were women, and the average age was 44-years-old. Islands of basaloid keratinocytes, some of which contained horn cysts and abortive follicles, were embedded in a desmoplastic stroma. In other foci, ducts and gland-like structures lined by a two-cell layer predominated. In deep components individual and thin strands of cells dissected collagen bundles and skeletal muscle and invaded perineural spaces. Despite this, cytologic atypia and mitotic figures were rare. The cell of origin is considered to be a pluripotential adnexal keratinocyte which is capable of both follicular and sweat gland differentiation.

Adult↗
PubMed1982

Plastic embedding of cutaneous specimens: an important diagnostic aid in mycosis fungoides.

A technique for primary plastic embedding for light microscopy was utilized in evaluating plaque lesions in four patients with mycosis fungoides and compared to tissues from the same patients embedded in paraffin. Standard 3 mm punch biopsies were utilized. Specimens were fixed in B-5 and embedded in araldite epoxy resin. In specimens from all four patients, the cytological details of the mycosis cells were superior in the plastic embedded tissues. this practical and relatively inexpensive method may prove to be a sensitive indicator of mycosis cells in early lesions. This technique also permits the use of a variety of special stains, immunoperoxidase and electron microscopic analyses.

Aged↗
PubMed1982

Cutaneous histiocytoid hemangioma.

Three cases of Kimura's disease or angiolymphoid hyperplasia with eosinophilia without the characteristic inflammatory infiltrate are reported. These unusual variants support the contention that the common denominator of these vascular lesions, whether they occur in the skin or (more rarely) in extracutaneous sites, is a histiocytoid endothelial cell. Since the composition of the associated inflammatory cell infiltrate is highly variable, a more appropriate term for these lesions is "histiocytoid hemangioma."

Adult↗
PubMed1982

An elastic tissue defect in dermatofibrosis lenticularis disseminata. Buschke-Ollendorff syndrome.

A patient with dermatofibrosis lenticularis disseminata (Buschke-Ollendorff syndrome) was found to have a distinctive abnormality of the cutaneous elastic tissue. This abnormality, studied by histochemical and ultrastructural techniques, was characterized by the presence of hyalinized, thick fibers that entrapped normal bundles of collagen. Histochemically, these fibers stained like elastin but showed certain tinctorial characteristics of pre-elastin. Ultrastructurally, this elastin-like substance was composed of large clumps of electron-dense material with a fine fibrillar coating. The changes were sufficiently distinctive to be diagnosed by light microscopy.

Collagen↗
PubMed1981

Diaper dermatitis with psoriasiform ID eruption.

Diaper dermatitis with psoriasiform ID eruption has a distinct clinical presentation. Its etiology and relationship to psoriasis remain uncertain. Previous reports have shown histologic features of subacute to chronic dermatitis. Two cases are presented in which a biopsy of secondary lesions showed features characteristic of psoriasis. It is possible that such cases represent those patients with a psoriatic diathesis.

Biopsy↗
PubMed1981

Multiple fibrofolliculomas with trichodiscomas and acrochordons.

The syndrome of multiple fibrofolliculomas with trichodiscomas and acrochordons clinically is characterized by asymptomatic dome-shaped papules primarily involving the head, neck, chest, back, and arms. These tumors represent benign proliferations of the mesodermal and ectodermal components of the pilar apparatus. Substantial overlap between each of these lesions exists. Individual patients also exhibit a disease spectrum in which various tumors preponderate. The stimulus for this proliferation may be genetically determined, but the cause remains unknown. Merkel's cells were not identified in an electron microscopic study of a single trichodiscoma, but banded structures similar to those described in the closely related lesions of perifollicular fibroma and fibrous papule were seen.

Adult↗
PubMed1980

Desmoplastic nevus: a distinct histologic variant of mixed spindle cell and epithelioid cell nevus.

From a series of 75 cases of mixed spindle cell and epithelioid cell nevi, 14 were designated as desmoplastic nevi. Junctional activity, theque formation, and pigmentation were uncommon features. As a result, desmoplastic nevi may be confused with a variety of fibrohistiocytic lesions. Well defined intranuclear invaginations of cytoplasm occurred in 12 cases, and were helpful in differentiating desmoplastic nevi from these lesions. Desmoplastic malignant melanoma must also be considered in the microscopic differential diagnosis, but distinguishing features of desmoplastic melanoma include the presence of preexisting lentiginous melanoma, and necrosis of tumor cells and collagen. Desmoplastic nevus was compared to the ordinary variants of mixed spindle cell and eipthelioid cell nevus in an attempt to define etiologic factors responsible for a desmoplastic reaction. No satisfactory explanation could be found since the clinical variables examined were not statistically different.

Adolescent↗
PubMed1980

Elastosis perforans serpiginosa associated with morphea. An example of "performing morphea".

A 16-year-old girl is described with elastosis perforans serpiginosa occurring within a lesion of morphea. Histologic examination showed a definite relationship between the abnormal elastic fibers in the perforation and in foci of surrounding morphea. Although the concurrence of these conditions may be coincidental, we believe that this case represents perforating morphea, a secondary form of elastosis perforans serpiginosa.

Adolescent↗
PubMed1980

Childhood lichen planus--a question of therapy.

Diffuse lichen planus, a rare disorder in children, was observed in an 8-year-old boy. Effective therapy in this disease remains a problem and currently relies predominantly on the use of the corticosteroids. The complications attendant with corticosteroid administration in children are discussed and a review of alternate modes of therapy for lichen planus is presented.

Adrenal Cortex Hormones↗