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Biomedical subjects

R Czekanowski

Publications and source records attributed to R Czekanowski.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Analysis of the correlation between the dose-response curve for prostaglandin F2alpha and the progress of pregnancy, cervix ripening, pharmacologic estrogen premedication and Partusisten administration in prostaglandin-induced labor].

Correlation between sensibility of PGF2 alpha (dose-response) curve and parameters of inductibility - duration of gestation, cervix score, application of estrogens and Partusisten were investigated. 90 patients in high risk pregnancy were observed. It was stated that the sensibility toward of PGF2 alpha is reciprocal proportional to the age of pregnancy and cervix score and proportional direct to pretreatment of Partusisten. Estrogens don't change the sensibility of the uterus to the PGF2 alpha.

Adult↗
PubMed1980

[In vitro studies into interdependence of volume and pressure in non-pregnant human uterus (author's transl)].

This paper follows on studies undertaken earlier into physiological and pharmacological aspects relating to the nonpregnant uterus of women in sexual maturity. The interdependence between volume and pressure is described with reference to a known model of the non-pregnant uterus. -- Uterus expansiveness in the second phase of the cycle was found to be larger than that in the first phase. The interdependence between volume and intra-uterine pressure is of linear nature. Intramural pressure and changes in perfusion pressure are but negligibly affected by volume enlargement and expansion of the uterine cavity and not even by intrauterine pressure which increase beyond 400 mmHg. This is attributable to a number of factors, borne out by both Laplace's formula and the authors' own findings, such as a relatively small volume, small radius, and larger wall thickness of the non-pregnant uterus. Optimum contractility depends on optimum volume, the latter being typical of the individual uterus. Excessive volume is likely to lead to higher intra-uterine and intramural tonus. Discoordination of contractility, rise in tonus, alteration of the contraction amplitude, and rise in frequency are consequences. Both change in volume and passive expansiveness of the uterus will not really affect blood supply unless major changes occurred to intramural pressure (in excess of something between 70 and 80 mmHg) to obstruct the blood flow. High intramural pressures are required because of the small volume of the nonpregnant uterus, in order to cause contractility strong enough to eject the content of the uterus, for example, in menstruation.

Adult↗
PubMed1980

[Comparison between haemostatic parameters of full - term and premature newborns (author's transl)].

Twenty-five full-term newborns were compared to 20 premature newborns for several haemostatic parameters. The latter group exhibited no clinical symptoms of respiratory distress syndrome, except for two cases. The coagulative system was activated in either group. Differences were clearly recordable from the fibrinolytic system and indicated activation of fibrinolysis in full-term newborns and relative insufficiency of the same system in premature newborns. The need for assessment of both the coagulative system and fibrinolysis in any case of premature delivery is suggested by the authors and considered necessary for diagnosis, prophylaxis, and possible therapy of respiratory distress syndrome. Activation of fibrinolysis is interpreted as a mechanism of defence against concomitant intravascular coagulation, while the absence of compensation in the fibrinolytic system of the newborn is considered to be a mechanism which might lead to hyaline membrane syndrome.

Blood Coagulation↗
PubMed1977

[Correlation between the perfusion, perfusion pressure and contractile activity in the nonpregnant uterus].

This paper presents the results of investigations on the dependence between the flow and intravascular pressure and uterine contractile activity. The pressure in the vascular bed was monitored with a pressure transducer and the contractile activity by means of an intrauterine ballon was measured. In a part of experiments, the flow was recorded with a flowmeter. The investigations were performed on 27 nonpregnant human uteri in various phases of the menstrual cycle. Uterus was perfused with a perfusion pump, starting from the perfusion pressure of 50 to 60 mm Hg and on up to maximum values of 140 mm Hg. It has been found that with an increase in the uterine flow, intravascular pressure increases too. This pressure-flow relationship is linear. An increase in flow through the nonpregnant uterus leads to an increase in intravascular pressure from 61.5 mm Hg to 142 mm Hg with a simultaneous increase in the human uterine basal tonus from the 6.2 mm Hg initial value to the average value of 25 mm Hg at the perfusion pressure of 140 mm Hg and an decrease in frequency from 6.6 to 5.2 contractions/10 min. With an increase of flow, however, there is a increase in amplitude which reaches highest values at the 100 mm Hg perfusion pressure and than no significant increase in amplitude is observed. An increase in amplitude is accompanied by an increase in contractile activity. It should be concluded that hemodynamic conditions and the state of vessels play a controlling role in the process of the uterine activity.

Blood Pressure↗
PubMed1977

[Physiological and pharmacological studies of umbilical cord flow in man].

The results of investigations on physiology and pharmacology of the smooth muscle umbilical cord arteries are presented. In the first part of the investigations it has been found that there is a close dependence between the blood flow and perfusion pressure in the arterial bed of the cord. The pressure flow relationship is linear. The blood vessels of the umbilical cord influence actively the perfusion pressure changes. On the basis of the presented investigations, the possibility of existence of autoregulation in the umbilical cord circulation has been found which testifies to an active but not passive role of the vessels in the circulation between the foetus and placenta. It has been stated that the umbilical cord vessels show a spontaneous contractile activity which may play an important role in the regulation of the umbilical flow. In the case of lack of the smooth muscle spontaneous contractile activity, this could be induced by using active pharmacological substances, as for instance noradrenaline. The reaction of another important pharmacological substance bradykinin (BRS), has been closely associated with oxygen saturation of the perfusion solution. Changes in the sensitivity of the umbilical cord blood vessels to BRS, depending on the saturation with oxygen, have been emphasised, and the role and participation of kinins in closing up umbilical cord blood vessels immediately following labour have been discussed.

Bradykinin↗
PubMed1977

[Investigations of the human isolated nonpregnant uterus contractility in the course of the menstrual cycle by measuring intramyometrial pressure (author's transl)].

In this work, the behaviour of the intramyometrial pressure, registered in the wall of the myometrium of the human isolated nonpregnant uterus, has been followed up. Intramyometrial pressure measurements were performed in 33 uteri. Simultaneously the intravascular pressure was monitored. The values of the intramyometrial pressure correspond with the intrauterine pressure, and the pressure in the uterine cavity, measured with the use of inserted balloon, was a resultant of the intrauterine pressure measured in the corpus uteri and isthmus at the same time. It has been found that in the course of the sexual cycle, nonpregnant human uterus shows irregular contractile activity. The contractile activity of the nonpregnant human uterus is characterized by the lack of coordination of contractions among particular uterine regions registered simultaneously. During the course of the menstrual cycle the isthmus region was dominating and revealed a pacemaker properties and during menstrual bleeding corpus uteri dominated. The results were discussed and the close relationship between uterine contractility and intravascular pressure was underlined.

Female↗