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Biomedical subjects

R Bernard

Publications and source records attributed to R Bernard.

At least 127 records · Page 7Linked to original sources
PubMed1978

[Evaluation of one year experience with cerebral tomodensitometry in pediatric neurology].

Cerebral tomography allows the delineation of areas modified by edema or necrosis, the visualization of calcifications undetectable by standard x-ray examination, extra- or intra-cerebral blood effusions and neoformations of the cerebrum or of its envelopes. It also reveals slight or localized cerebral atrophies that other neuro-radiologic techniques sometimes failed to detect. It appears therefore worthwhile to reconsider pediatric neurology according to this new type of investigation. Its sole difficulty in young children, is the requirement of a half hour immobility, best obtained by general anesthesia. However, the rapid improvements of this technique will probably permit to overcome this slight drawback.

Brain Diseases↗
PubMed1977

Cardiac output monitoring during the acute phase of myocardial infarction: accuracy and precision of the thermodilution method.

A triple human catheter was used for the determination of cardiac output during the acute phase of moycardial infarction in 23 patients. The correlation coefficient between thermodilution and the Fick method was 0.91. Precision of the method assessed by multiple repeated determinations was 4.8 or 5.6%. Quadruplicate determinations allowed to detect variations of cardiac output in the range of 0.465 1/min. Variation between two successive determinations of more than 9.4% can probably be attributed to a technical error.

Acute Disease↗
PubMed1977

[Experimental models for the pharmacologic study of anti-arrhythmia drugs].

In order to assess the value and therapeutic safety of an antiarrhythmic drug, it must be submitted to multiple tests, which reproduce as faithfully as possible the conditions observed in human pathology. The main experimental approaches are presented here: screening and control tests. For each test, the authors emphasize the various experimental factors limiting their interpretation and allowing the extrapolation to men.

Aconitine↗
PubMed1977

[Evaluation of the efficacy of anti-arrhythmic drugs using a computer].

To palliate the deficiencies of the oscilloscopic monitoring of arrhythmias, an automatic system has been developed. It has been used during more than one year time in the Coronary Unit for supervision of patients and for study of the pharmacological effects of antiarrhythmic drugs.

Anti-Arrhythmia Agents↗
PubMed1976

A comparison of flexible and nonflexible plastic cannulae for performing first trimester abortion.

The safety and effectiveness of flexible and nonflexible plastic cannulae used in vacuum aspiration abortion for patients at 6 to 12 weeks' gestation were evaluated in a study of 1100 physically healthy women in Ljublijana, Yugoslavia. To minimize study biases, each type of cannulae was randomly assigned to 550 patients. To minimize evaluator bias, a second physician who was kept unaware of which cannula was used for particular patient was responsible for evaluating patients after the procedures. Both groups of patients were similar with respect to age, parity, marital status, formal education and gestational age. Higher rates of retained tissue and cannula obstruction were obtained with the flexible cannula. The two types of cannulae were not significantly different with respect to other criteria of evaluation.

Abortion, Induced↗
PubMed1976

[Humoral immunity and blastic transformation of lymphocytes in trisomy 21].

Studies of immunologic parameters in 52 children with trisomy 21 revealed that -the changes in serum immunoglobulin patterns were minimal, although some delay in the age-dependent rise of IgG concentration was observed; -lymphocyte reactivity to phytohemagglutinin showed a shift with maximal 3H-thymidine incorporation at low PHA concentration; -presence of HBs antigen at an increased incidence, possible existence of anti-thyroid antibodies in serum of trisomy patients and also in that of their parents, abnormalities in phagocytosis, illustrate that trisomy 21 can be associated with multiple immunologic dysfunctions.

Adolescent↗