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Biomedical subjects

R Baumgarten

Publications and source records attributed to R Baumgarten.

At least 109 records · Page 6Linked to original sources

[Rational diagnosis of functional hyperbilirubinemia and management of patients with Gilbert-Meulengracht syndrome].

Between 1981 and 1986 we have investigated 143 outpatients with symptoms of G.M.S. Analysis of the different diagnostic procedures aimed at standardization of diagnostic measures in patients with mild unconjugated hyperbilirubinaemia without other abnormal physical findings. In these patients and in persons with only anamnestic disorder, diagnosis was ensured by oral application of nicotine acid. The principles of the specific diagnostic procedure are described. In general, diagnosis of G. M. S. is possible without histological investigation of liver tissue.

Adolescent↗

[Delta virus superinfection in a patient with chronic viral hepatitis B].

Hepatitis-Delta virus is a defective RNA virus enclosing the Delta antigen and genome within a coat of hepatitis B surface antigen (HBsAg). Prevalence of Delta virus is limited to individuals with hepatitis B infection. Two modes of infection have been identified: coinfection with hepatitis virus B of healthy individuals and superinfection of HBsAg carriers. In a prospective study of 485 liver biopsies from HBsAg seropositive patients, 320 non-replicative HBsAg carriers (without evidence of core antigen) were discovered. In only one of these cases could a Delta virus superinfection be confirmed by immunohistology. It caused a shift from a preexisting chronic persistent to a chronic active hepatitis. This is the first case of chronic Delta virus infection confirmed by immunhistology in the G.D.R.

Adult↗

[Hepatitis B risk in dental personnel].

Dependent on the profession, medical personal is at different risk of hepatitis B infection. 505 staff members of 48 Berlin dental clinics were investigated for hepatitis B virus markers and demonstrated a significantly lower prevalence of HBsAg and its antibody than other hospital personal: anti-HBs positivity (EIA) was found in only 5.5 per cent of them (dental technicians: 1.6%, dental assistants: 3.8%, dentists: 8.0%). We conclude that in the GDR dental staff is not at higher risk of hepatitis B infection than other non-risk medical personal. Legal aspects of insurance and measures for hygienic prevention in dental practice are discussed.

Adult↗

[Course control and significance of circulating HBsAg-specific immune complexes in acute viral hepatitis B].

The occurrence and behaviour of circulating HBsAg-specific immune complexes were investigated in 52 patients suffering from acute viral hepatitis B. In 6 patients the illness took a chronic course. The determination was carried out by precipitation with polyethylene glycol 6,000 and the increase of HBsAg concentration after antibody splitting from the complexes by trypsin treatment. The results allow following conclusions: The early presence of immune complexes suggests a specific antibody response also against HBsAg before development of clinical illness. The timing and strength of this humoral immune reaction is sex dependent; females show anti-HBs earlier and in higher titers. The course of the concentration of circulating immune complexes depends on the immunoglobulin class of antibody and the quickness of virus elimination. The determination of circulating unspecific or HBsAg-specific immune complexes does not allow to draw any prognostic conclusion to the further course of acute hepatitis B. Only in chronificating cases, the future activity of the chronic HBV infection may be expected by the early behaviour of HBsAg immune complexes. Also patients developing chronic course of the HBV infection demonstrated a "peak" of the immune reaction 6-8 weeks after the beginning of disease, which could offer the point of time for starting an immunomodulating therapy.

Adolescent↗

[Zoonoses].

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Animals↗

[Principles of cooperation between the specialties of internal medicine, pathology and clinical biochemistry].

The optimal utilization of the knowledge and possibilities of pathological and clinical biochemistry presumes a close cooperation between it and the clinical specialties. The common working team of the GDR Society of Internal Medicine and the GDR Society for Clinical Chemistry and Laboratory Diagnostics makes theses of the central points of the cooperation in care, education, further education and postgraduate study and in research a subject for discussion. As essential tasks in the process of medical care are regarded the balance of the examination programme standing at the disposal, the establishment of diagnostic programmes, the establishment of organisational measures, the ascertainment of a use according to indication, the guarantee of the representance of examination material, the control of plausibility and the interpretation of test results. Since the realization of the tasks to a large extent depends on the cooperation of the specialities in education, further education and postgraduate study during the further education the clinician should become acquainted with the possibilities, the limits and the prerequisites for the performance of laboratory diagnostic investigations, the clinical biochemist with the problems of medical care and the value of the laboratory diagnosis in the total process of the treatment. In the field of research the result is a necessary cooperation in the clarification of patho-biochemical mechanisms, in the search for suitable laboratory diagnostic parameters for diagnostics and control of the course as well as in the statement of the validity of laboratory diagnostic parameters and parameter combinations taking into consideration the factors expenses, benefit and risk as well as further diagnostic possibilities.

Biochemistry↗