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Biomedical subjects

R Baumgarten

Publications and source records attributed to R Baumgarten.

At least 91 records · Page 5Linked to original sources
PubMed1989

[Causal therapy possibilities in HIV infections].

By means of the replication cycle of human immunodeficiency virus (HIV) some starting points for antiviral chemicals are outlined. Only azidothymidine is approved yet for treatment of AIDS patients. It restrains virus multiplication, improves the general immunologic situation, and in case of HIV encephalopathy it leads to marked clinical improvement. However, the indications of azidothymidine are limited by its unwanted side reactions. Seemingly the therapeutic effect is only a temporary one. Contagiosity of treated patients remains unaffected. Out of the bulk of chemicals now under investigation in laboratory and clinic those should have the best chance to be successful which interfere with protein products of the viral control genes.

Antiviral Agents↗
PubMed1989

Kinetics of antipyrine and sulfamethazine in patients recovered from dihydralazine-hepatitis.

Pharmacokinetic studies with sulfamethazine (500 mg) and antipyrine (15 mg/kg) were performed in 27 hypertonic patients (16 females, 11 males, 37-78 years) who had recovered from a dihydralazine-induced hepatitis, and 21 patients with essential hypertension (13 females, 8 males, 18-74 years) treated with antihypertonics excluding dihydralazine. 20 patients of the hepatitis group (74%) and 12 patients of the control group (57%) were slow acetylators. With regard to the pharmacokinetic parameters no differences were found in both slow and rapid acetylators between the sulfamethazine group and the antipyrine group.

Acetylation↗
PubMed1988

[HIV (human immunodeficiency virus) and HIV-associated diseases].

The discovery of the Human Immunodeficiency Virus (HIV), the characterization of its molecular biology and the development of serologic methods for detecting antibodies have led to a better understanding of HIV-associated clinical syndromes. Recently, the Centre of Disease Control has proposed a classification of HIV-related conditions. This classification forms the basis for this review. It is completed by remarks on antiviral and immunomodulating drugs and its effects on HIV. Difficulties in development of vaccines are discussed.

AIDS Serodiagnosis↗
PubMed1988

[Fever--infection].

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Bacterial Infections↗
PubMed1987

[Bone marrow aplasia: a rare complication in virus-induced hepatitis].

Bone marrow aplasia associated with acute viral hepatitis is a rare, in the rule late complication. A prognostic relation between the latency of acute hepatitis and the development of aplastic anemia is described. We report a case of nearly symptomless hepatitis in a 25 year old women with a fatal course of aplastic anemia. First clinical symptoms were caused by aplastic anemia. The pathogenesis of aplastic anemia associated to viral hepatitis is obscure. Genetic and immunological causes are discussed. A direct viral action is possible. Because the main part of the described cases is caused by non-A, non-B hepatitis, it seems apparent that at least a non-A, non-B virus strain could have an affinity to bone marrow cells. Ensuring this, relations will be impossible up to the identification of the virus.

Adult↗